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    Medical devices containing rapamycin analogs
    3.
    发明授权
    Medical devices containing rapamycin analogs 有权
    含有雷帕霉素类似物的医疗器械

    公开(公告)号：US07455853B2

    公开(公告)日：2008-11-25

    申请号：US10488815

    申请日：2002-09-10

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61F2/00 ,  A01N43/42

    CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/606 ,  C07D498/18

    摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs

    摘要翻译： 一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层， 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）。 该药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合

    Medical Devices Containing Rapamycin Analogs
    4.
    发明申请
    Medical Devices Containing Rapamycin Analogs 审中-公开
    含雷帕霉素类似物的医疗器械

    公开(公告)号：US20080153790A1

    公开(公告)日：2008-06-26

    申请号：US12044677

    申请日：2008-03-07

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61K31/436 ,  A61K31/56 ,  A61P29/00

    CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

    摘要： A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to drugs of Formula (I). The drugs of Formula (I) can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 医疗装置包括能够容纳或支撑药学上可接受的载体或赋形剂的支持结构，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包括涂层，并且包含 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）的药物。 式（I）的药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物， 细胞去分化抑制剂，细胞抑制药物或这些药物的组合。

    Medical Devices Containing Rapamycin Analogs
    8.
    发明申请
    Medical Devices Containing Rapamycin Analogs 审中-公开
    含雷帕霉素类似物的医疗器械

    公开(公告)号：US20090047323A1

    公开(公告)日：2009-02-19

    申请号：US12255603

    申请日：2008-10-21

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61F2/04 ,  A61K31/436 ,  A61K31/565

    CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

    摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层， 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）。 该药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

    Medical Devices Containing Rapamycin Analogs
    9.
    发明申请
    Medical Devices Containing Rapamycin Analogs 审中-公开
    含雷帕霉素类似物的医疗器械

    公开(公告)号：US20080175884A1

    公开(公告)日：2008-07-24

    申请号：US12041537

    申请日：2008-03-03

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61K9/00 ,  A61K31/4745 ,  A61K31/56

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

    摘要： A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to drugs of Formula (I). The drugs of Formula (I) can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 医疗装置包括能够容纳或支撑药学上可接受的载体或赋形剂的支持结构，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包括涂层，并且包含 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）的药物。 式（I）的药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物， 细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。