-
公开(公告)号：US06228867B1
公开(公告)日：2001-05-08
申请号：US09275951
申请日：1999-03-25
IPC分类号： A61K31345
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
-
公开(公告)号：US06211224B1
公开(公告)日：2001-04-03
申请号：US09178688
申请日：1998-10-26
IPC分类号： A61K31404
CPC分类号： C07D209/14
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。
-
公开(公告)号：US6159989A
公开(公告)日：2000-12-12
申请号：US465199
申请日：1999-12-15
IPC分类号： A61P15/08 , C07D453/06 , C07D487/08 , A61K31/405 , A61K31/454 , C07D211/26 , C07D401/14
CPC分类号： C07D487/08 , C07D453/06
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
-
公开(公告)号：US6077847A
公开(公告)日：2000-06-20
申请号：US275950
申请日：1999-03-25
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
-
公开(公告)号：US5985892A
公开(公告)日：1999-11-16
申请号：US275752
申请日：1999-03-25
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
-
公开(公告)号：US5849764A
公开(公告)日：1998-12-15
申请号：US760817
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
发明人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
IPC分类号： C07D20060101 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/40 , C07D209/02 , C07D215/12
CPC分类号： C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
-
公开(公告)号：US5565485A
公开(公告)日：1996-10-15
申请号：US294232
申请日：1994-08-22
申请人： Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy J. Kevin , Douglas J. Pettibone , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Richard B. Toupence , Jay M. Matthews
发明人： Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy J. Kevin , Douglas J. Pettibone , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Richard B. Toupence , Jay M. Matthews
IPC分类号： C07C59/70 , C07C65/24 , C07C311/51 , C07D257/04 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , A61K31/335 , A61K31/535 , C07D265/30 , C07D319/08
CPC分类号： C07D257/04 , C07C311/51 , C07C59/70 , C07C65/24 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , Y10S514/869
摘要： Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
摘要翻译： 苯氧基苯基乙酸和一般结构式I的衍生物具有内皮素拮抗剂活性，可用于治疗心血管疾病，如高血压，缺血性肾衰竭，血管痉挛，脑和心脏缺血，心肌梗死，内毒素性休克，良性前列腺增生 ，包括雷诺氏病和哮喘的炎性疾病。
-
公开(公告)号：US20100252467A1
公开(公告)日：2010-10-07
申请号：US12750928
申请日：2010-03-31
CPC分类号： A61B17/3215 , A61B50/3001 , A61B2017/0046 , A61B2090/0801 , Y10T29/49826
摘要： A package for a surgical blade tip is provided herein. The package cooperates with the surgical blade tip to properly retain it and facilitate mounting onto a surgical blade handle. In one aspect, the invention includes a package having a body with a side wall and at least two detents extending inwardly from the side wall. In addition, a surgical blade tip is provided having an adaptor with a blade extending therefrom. The adaptor includes at least two recesses formed therein. The surgical blade tip is disposed in the package with the detents being at least partially inserted into the recesses. Also, the detents are configured to apply a retentive force to the adaptor to retain the adaptor in a first position and configured to deflect with a predetermined amount of torque being applied to the surgical blade tip so as to permit the adaptor to rotate from the first position to a second position where the detents are not inserted into the recesses. Advantageously, with the subject invention, a package may be provided which maintains a blade of a surgical blade tip in spaced relationship so as to minimize contamination thereof. In addition, the interengagement of the detents and the recesses allows for proper retention of the surgical blade tip during mounting onto a surgical blade handle.
摘要翻译： 本文提供了用于手术刀片尖端的包装。 该包装与外科手术刀片尖端协作以适当地保持其并且便于安装到外科手术刀柄上。 一方面，本发明包括具有侧壁的主体和从侧壁向内延伸的至少两个棘爪的包装。 此外，提供具有带有从其延伸的刀片的适配器的手术刀片尖端。 适配器包括形成在其中的至少两个凹部。 手术刀片尖端设置在包装中，其中止动件至少部分地插入到凹部中。 而且，棘爪构造成将保持力施加到适配器以将适配器保持在第一位置，并且被配置成以施加到手术刀片尖端的预定量的扭矩偏转，从而允许适配器从第一位置旋转 位置到第二位置，其中棘爪不插入凹槽中。 有利地，对于本发明，可以提供一种包装，其保持手术刀片尖端的叶片间隔开的关系，以使其污染最小化。 此外，棘爪和凹部的相互接合允许在安装到外科手术刀柄上时手术刀片尖端的适当保持。
-
公开(公告)号：US20090298949A1
公开(公告)日：2009-12-03
申请号：US12540445
申请日：2009-08-13
IPC分类号： A61K31/138
CPC分类号： C07C233/18 , C07C215/50 , C07C215/52 , C07C217/58 , C07C229/14 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07D213/38 , C07D241/12 , C07D249/12 , C07D295/096 , C07D307/52 , C07D309/04 , C07D309/14 , C07D319/12 , C07D333/48
摘要： The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making the compounds. This and other aspects of the invention are realized upon review of the entire specification.
摘要翻译： 本发明涉及曼尼希碱抗疟氨基烷基苯酚化合物及其抗疟原虫的原生动物的用途，特别是新出现的抗药性血浆的菌株。 本发明还涉及含有这些化合物的组合物和制备该化合物的方法。 本发明的这个和其它方面在整个说明书的审查之后实现。
-
公开(公告)号：US06288078B1
公开(公告)日：2001-09-11
申请号：US09520331
申请日：2000-03-07
IPC分类号： C07D47104
CPC分类号： C07D471/04 , A61K31/437
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
-
-
-
-
-
-
-
-
-
搜索结果
78 条记录 (耗时 0.038 秒)
