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公开(公告)号:US5849764A
公开(公告)日:1998-12-15
申请号:US760817
申请日:1996-12-05
申请人: Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
发明人: Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
IPC分类号: C07D20060101 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/40 , C07D209/02 , C07D215/12
CPC分类号: C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US5780437A
公开(公告)日:1998-07-14
申请号:US760816
申请日:1996-12-05
申请人: Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
发明人: Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
IPC分类号: C07D20060101 , C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08 , A61K38/00 , A61K31/40 , A61K31/54
CPC分类号: C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译: 公开了式(I)的化合物及其药学上可接受的盐,其可用作GnRH的拮抗剂,因此可用于治疗两种男性中各种性激素相关和其他病症 和妇女。
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公开(公告)号:US06200957B1
公开(公告)日:2001-03-13
申请号:US09115497
申请日:1998-07-14
申请人: Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Peter Lin , Mitree M. Ponpipom , Matthew J. Wyvratt , Narindar N. Girotra , Jonathan Young
发明人: Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Peter Lin , Mitree M. Ponpipom , Matthew J. Wyvratt , Narindar N. Girotra , Jonathan Young
IPC分类号: C07D20910
CPC分类号: C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US5756507A
公开(公告)日:1998-05-26
申请号:US760851
申请日:1996-12-05
申请人: Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
发明人: Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
IPC分类号: C07D209/14 , C07D209/16 , A61K31/405 , A61K31/495 , C07D209/10 , C07D403/06
CPC分类号: C07D209/14 , C07D209/16
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US6156767A
公开(公告)日:2000-12-05
申请号:US83477
申请日:1998-05-22
IPC分类号: C07D401/12 , C07D401/14 , C07D487/08 , C07D217/00 , A61K31/56 , C07D215/12 , C07D401/00
CPC分类号: C07D401/14 , C07D401/12 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用作GnRH的拮抗剂,因此可用于治疗男性和女性中各种性激素相关和其他病症。
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公开(公告)号:US06197975B1
公开(公告)日:2001-03-06
申请号:US09077565
申请日:1998-06-01
IPC分类号: C07D40312
CPC分类号: C07D401/06 , C07D209/14 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/10
摘要: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用作GnRH的拮抗剂,因此可用于治疗男性和女性中各种性激素相关和其他病症。
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公开(公告)号:US06211224B1
公开(公告)日:2001-04-03
申请号:US09178688
申请日:1998-10-26
IPC分类号: A61K31404
CPC分类号: C07D209/14
摘要: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用作GnRH的拮抗剂,因此可用于治疗男性和女性中各种性激素相关和其他病症。
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公开(公告)号:US6159989A
公开(公告)日:2000-12-12
申请号:US465199
申请日:1999-12-15
IPC分类号: A61P15/08 , C07D453/06 , C07D487/08 , A61K31/405 , A61K31/454 , C07D211/26 , C07D401/14
CPC分类号: C07D487/08 , C07D453/06
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US6017944A
公开(公告)日:2000-01-25
申请号:US178689
申请日:1998-10-26
IPC分类号: A61P15/08 , C07D453/06 , C07D487/08 , A61K31/40 , A61K31/405 , C07D209/02 , C07D209/12 , C07D403/10
CPC分类号: C07D487/08 , C07D453/06
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US06077858A
公开(公告)日:2000-06-20
申请号:US401416
申请日:1999-09-21
申请人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D409/14 , C07D487/08 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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