公开(公告)号：US20210403479A1

公开(公告)日：2021-12-30

申请号：US17288626

申请日：2019-11-04

申请人： Merck Sharp & Dohme Corp.

发明人： Wensheng Yu ,  Joseph Kozlowski ,  Dane James Clausen ,  Jian Liu ,  Younong Yu ,  Ming Wang ,  Bing Li

IPC分类号： C07D487/10 ,  C07D403/12 ,  C07D413/14 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  C07D417/14 ,  C07D498/10 ,  C07D405/14 ,  A61K45/06

摘要： The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4 and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.

公开(公告)号：US11208407B2

公开(公告)日：2021-12-28

申请号：US16631191

申请日：2018-07-30

申请人： Merck Sharp & Dohme Corp.

发明人： Hua Zhou ,  Abdelghani Achab ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  David L. Sloman ,  Wensheng Yu

IPC分类号： C07D471/04 ,  C07D235/14

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I) Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210317091A1

公开(公告)日：2021-10-14

申请号：US16761855

申请日：2018-11-09

申请人： MERCK SHARP & DOHME CORP.

发明人： Yongxin Han ,  Abdelghani Achab ,  Indu Bharathan ,  Xavier Fradera ,  Derun Li ,  Nunzio Sciammetta ,  Wensheng Yu

IPC分类号： C07D241/12 ,  C07D213/64 ,  C07D213/56 ,  C07D239/26 ,  C07D413/04 ,  C07D241/18 ,  C07D237/08 ,  C07D213/76 ,  C07D401/04 ,  C07D405/10 ,  A61K45/06

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an 1DO-associated disease or disorder.

公开(公告)号：US11111232B2

公开(公告)日：2021-09-07

申请号：US16753050

申请日：2018-10-04

申请人： MERCK SHARP & DOHME CORP.

发明人： Catherine M. White ,  Abdelghani Achab ,  Indu T. Bharathan ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Jongwon Lim ,  Kun Liu ,  Meredeth Ann McGowan ,  Nunzio Sciammetta ,  Wensheng Yu ,  Hongjun Zhang ,  Hua Zhou

IPC分类号： A61K31/4418 ,  C07D401/14 ,  C07D213/74 ,  C07D401/12 ,  C07D405/12 ,  C07D413/14 ,  C07D417/14

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11103493B2

公开(公告)日：2021-08-31

申请号：US16631192

申请日：2018-07-30

申请人： Merck Sharp & Dohme Corp.

发明人： Hua Zhou ,  Xavier Fradera ,  Yongxin Han ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  Catherine White ,  Wensheng Yu

IPC分类号： A61K31/444 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/08 ,  C07D401/14 ,  C07D471/04

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210179607A1

公开(公告)日：2021-06-17

申请号：US16758717

申请日：2018-10-29

申请人： Merck Sharp & Dohme Corp.

发明人： Yongqi Deng ,  Abdelghani Achab ,  Bridget A. Becker ,  David Jonathan Bennett ,  Indu Bharathan ,  Xavier Fradera ,  Craig Gibeau ,  Yongxin Han ,  Derun Li ,  Kun Liu ,  Qinglin Pu ,  Sulagna Sanyal ,  David Sloman ,  Wensheng Yu ,  Hongjun Zhang

IPC分类号： C07D471/04 ,  C07D215/14 ,  A61K45/06

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10787441B2

公开(公告)日：2020-09-29

申请号：US16094621

申请日：2017-04-17

申请人： Merck Sharp & Dohme Corp.

发明人： Joseph A. Kozlowski ,  Wensheng Yu ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang ,  Zhixin Lei

IPC分类号： A61K31/4178 ,  C07D405/14 ,  A61K38/21 ,  A61K38/19 ,  A61K45/06

摘要： A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.

公开(公告)号：US10738062B2

公开(公告)日：2020-08-11

申请号：US16326043

申请日：2017-08-14

申请人： Merck Sharp & Dohme Corp.

发明人： Wensheng Yu ,  Joseph A. Kozlowski ,  Ling Tong ,  Craig A. Coburn ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

IPC分类号： C07D498/04 ,  A61K45/06 ,  A61K31/496 ,  A61K31/5365 ,  A61P31/14

摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US08178553B2

公开(公告)日：2012-05-15

申请号：US12690633

申请日：2010-01-20

申请人： Brian J. Lavey ,  Joseph A. Kozlowski ,  Guowei Zhou ,  Ling Tong ,  Wensheng Yu ,  Michael K. C. Wong ,  Shankar B. Bandarpalle ,  Neng-Yang Shih ,  M. Arshad Siddiqui ,  Kristin E. Rosner ,  Chaoyang Dai ,  Janeta Popovici-Muller ,  Vinay M. Girijavallabhan ,  Dansu Li ,  Aneta Maria Kosinski ,  Seong-Heon Kim ,  De-Yi Yang ,  Razia K. Rizvi

发明人： Brian J. Lavey ,  Joseph A. Kozlowski ,  Guowei Zhou ,  Ling Tong ,  Wensheng Yu ,  Michael K. C. Wong ,  Shankar B. Bandarpalle ,  Neng-Yang Shih ,  M. Arshad Siddiqui ,  Kristin E. Rosner ,  Chaoyang Dai ,  Janeta Popovici-Muller ,  Vinay M. Girijavallabhan ,  Dansu Li ,  Aneta Maria Kosinski ,  Seong-Heon Kim ,  De-Yi Yang ,  Razia K. Rizvi

IPC分类号： A61K31/4178 ,  A61K31/437 ,  A61K31/4439 ,  A61P3/00 ,  A61P29/00 ,  A61P11/00 ,  C07D491/048 ,  C07D471/04 ,  C07D401/14 ,  C07D403/06

CPC分类号： C07D403/14 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00

摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。

公开(公告)号：US20120010181A1

公开(公告)日：2012-01-12

申请号：US13127952

申请日：2009-11-09

申请人： Joseph A. Kozlowski ,  Wensheng Yu ,  Michael K.C. Wong ,  Seong Heon Kim ,  Ling Tong ,  Brian J. Lavey ,  Bandarpalle B. Shankar ,  De-Yi Yang ,  Robert Feltz ,  Aneta Maria Kosinski ,  Guowei Zhou ,  Razia K. Rizvi ,  Chaoyang Dai ,  Luke Fire ,  Vinay Girijavallabhan ,  Dansu Li ,  Janeta Popovici-Muller ,  Judson E. Richard ,  Kristen E. Rosner ,  M. Arshad Siddiqui ,  Liping Yang

发明人： Joseph A. Kozlowski ,  Wensheng Yu ,  Michael K.C. Wong ,  Seong Heon Kim ,  Ling Tong ,  Brian J. Lavey ,  Bandarpalle B. Shankar ,  De-Yi Yang ,  Robert Feltz ,  Aneta Maria Kosinski ,  Guowei Zhou ,  Razia K. Rizvi ,  Chaoyang Dai ,  Luke Fire ,  Vinay Girijavallabhan ,  Dansu Li ,  Janeta Popovici-Muller ,  Judson E. Richard ,  Kristen E. Rosner ,  M. Arshad Siddiqui ,  Liping Yang

IPC分类号： A61K31/4178 ,  C07D401/14 ,  C07D491/052 ,  C07D413/14 ,  C07D417/14 ,  C07D403/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/436 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61P29/00 ,  A61P19/02 ,  A61P1/02 ,  A61P35/00 ,  A61P35/04 ,  A61P25/00 ,  A61P27/06 ,  A61P1/00 ,  A61P17/06 ,  A61P9/00 ,  A61P31/18 ,  A61P31/04 ,  C07D403/06

CPC分类号： C07D403/14

摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.

摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。