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公开(公告)号:US20070203149A1
公开(公告)日:2007-08-30
申请号:US11677889
申请日:2007-02-22
申请人: Ragulan Ramanathan , Michael Miller , Swapan Chowdhury , Kevin Alton , Diane Grotz , Diane Rindgen , Amol Tendolkar
发明人: Ragulan Ramanathan , Michael Miller , Swapan Chowdhury , Kevin Alton , Diane Grotz , Diane Rindgen , Amol Tendolkar
IPC分类号: A61K31/506 , A61K31/551 , C07D403/14 , A61K31/522
CPC分类号: C07D401/14 , C07D409/14
摘要: In its many embodiments, the present invention provides a novel class of compounds of structural formula I as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的结构式I化合物作为CCR5受体的抑制剂,制备这些化合物的方法,含有一种或多种这类化合物的药物组合物,制备药物制剂的方法,其包含一种或多种这样的化合物 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CCR5相关的一种或多种疾病的方法。 本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒(HIV)的抗病毒剂或其它药剂的组合的用途。 本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎症性肠病,特应性皮炎,牛皮癣 ,哮喘,过敏或多发性硬化。
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公开(公告)号:US20070193105A1
公开(公告)日:2007-08-23
申请号:US11307784
申请日:2006-02-22
申请人: Michael Miller , Julianne Miller
发明人: Michael Miller , Julianne Miller
CPC分类号: A01K87/08
摘要: A fishing rod assembly is provided in which a sports style grip is incorporated into the rod handle. Sports include, but are not limited to—golf, tennis, baseball, pool, hockey, hunting, motorcycling, and auto racing. The sports style grip is representative of a grip found on a piece of equipment used by a participant of a particular sport. For example a grip used for a golf club or tennis racket, the handle of a baseball bat or pool cue, or the stick shift found in a sports car.
摘要翻译: 提供了一种钓鱼杆组件,其中将运动型手柄结合到杆手柄中。 体育包括但不限于高尔夫,网球,棒球,泳池,曲棍球,狩猎,摩托车和赛车。 运动风格的抓地力代表一个特定运动参与者使用的一件设备上的抓地力。 例如,用于高尔夫球杆或网球拍的手柄,棒球棒的手柄或游泳池提示,或在跑车中发现的棒移。
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公开(公告)号:USD548817S1
公开(公告)日:2007-08-14
申请号:US29258153
申请日:2006-04-18
申请人: Noah Dingler , Dominic Daunter , Kristen Swope , Michael Miller , Julian Giggs
设计人: Noah Dingler , Dominic Daunter , Kristen Swope , Michael Miller , Julian Giggs
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公开(公告)号:US20070178593A1
公开(公告)日:2007-08-02
申请号:US11623772
申请日:2007-01-17
申请人: Michael Miller , Gary Sandahl , David Peterson , Bruce Drummond , Mark Chamberlin , Benjamin Bowen , Grace St. Clair , William Gordon-Kamm
发明人: Michael Miller , Gary Sandahl , David Peterson , Bruce Drummond , Mark Chamberlin , Benjamin Bowen , Grace St. Clair , William Gordon-Kamm
IPC分类号: C12N15/82
CPC分类号: C12N15/8207
摘要: Methods of preparing microparticles for transformation of plant cells with compositions of interest, and compositions comprising the prepared particles and the associated compound(s) of interest are provided. Further provided are methods to deliver compositions of interest to plant cells for transient or stable incorporation in the genome, and any transformed plant cells, plants, and seeds produced thereby.
摘要翻译: 提供了制备用于转化目的组合物的植物细胞的微粒的方法,以及包含所制备的颗粒和所关联化合物的组合物。 还提供了将植物细胞感兴趣的组合物短暂地或稳定地并入基因组中的方法,以及由此产生的任何转化的植物细胞,植物和种子。
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公开(公告)号:US20070168305A1
公开(公告)日:2007-07-19
申请号:US11252487
申请日:2005-10-18
申请人: Valdimir Vapnik , Michael Miller
发明人: Valdimir Vapnik , Michael Miller
IPC分类号: G06F15/18
CPC分类号: G06K9/6269 , G06N20/00
摘要: A new machine learning technique is herein disclosed which generalizes the support vector machine framework. A separating hyperplane in a separating space is optimized in accordance with generalized constraints which are dependent upon the clustering of the input vectors in the dataset.
摘要翻译: 本文公开了一种新的机器学习技术,其概括了支持向量机框架。 分离空间中的分离超平面根据取决于数据集中的输入向量的聚类的一般约束进行优化。
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公开(公告)号:US20070161685A1
公开(公告)日:2007-07-12
申请号:US11559930
申请日:2006-11-15
申请人: Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
发明人: Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/44 , C07D213/56
CPC分类号: C07D417/06 , C07D213/40 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/12
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
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公开(公告)号:US20070142725A1
公开(公告)日:2007-06-21
申请号:US11305141
申请日:2005-12-16
申请人: Terry Hardin , Zachary Nicoson , Brian Zimmer , Michael Miller
发明人: Terry Hardin , Zachary Nicoson , Brian Zimmer , Michael Miller
IPC分类号: A61B6/00
CPC分类号: A61B90/39 , A61B2090/3987
摘要: A biopsy marker deployment device is provided herein. According to one exemplary embodiment, the deployment device includes a deployment assembly and an actuator configured to selectively actuate the deployment assembly. The deployment assembly is configured to selectively deposit a marker in a biopsy site through at least one aperture and to substantially reduce space between the aperture and the deployment assembly.
摘要翻译: 本文提供活检标记物展开装置。 根据一个示例性实施例,展开装置包括展开组件和构造成选择性地致动展开组件的致动器。 部署组件被配置为通过至少一个孔选择性地将活检部位中的标记物沉积,并且基本上减小孔和展开组件之间的空间。
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公开(公告)号:US20070126150A1
公开(公告)日:2007-06-07
申请号:US11303777
申请日:2005-12-16
申请人: Mahadevan GanapathiSubramanian , Byung-Jin Choi , Michael Miller , Nicholas Stacey , Michael Watts
发明人: Mahadevan GanapathiSubramanian , Byung-Jin Choi , Michael Miller , Nicholas Stacey , Michael Watts
IPC分类号: B29C43/02
CPC分类号: B29C43/021 , B29C33/444 , B29C43/003 , B29C43/50 , B29C2043/025 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T156/10
摘要: A method for spreading a conformable material between a substrate and a template having a mold. The method comprises positioning the mold to be in superimposition with the substrate defining a volume therebetween. A first sub-portion of the volume is charged with the conformable material through capillary action between the conformable material and one of the mold and the substrate. A second sub-portion of the volume is filled with the conformable material by creating a deformation in the mold.
摘要翻译: 一种在基材和具有模具的模板之间铺展适形材料的方法。 所述方法包括将所述模具定位成与所述基板重叠以限定其间的体积。 体积的第一子部分通过适形材料和模具和基底之一中的毛细管作用装入适形材料。 通过在模具中产生变形,体积的第二子部分由适形材料填充。
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公开(公告)号:US20070117214A1
公开(公告)日:2007-05-24
申请号:US11416999
申请日:2006-05-02
IPC分类号: G01N33/48
CPC分类号: G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/30 , G01N29/4436 , G01N2291/0255 , G01N2291/0256 , G01N2291/02836 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , Y10T436/2575
摘要: Methods and apparatuses for performing assays involving binding material elements with a plurality of bonds over a substantial area of a surface of a resonant device establishing a normalized exposure. The methods and apparatuses also involve controlling an external influence applied to the material elements over a first period of time and measuring a signal during a second period of time that is indicative of the change in the amount of material elements bound to the surface relative to the normalized exposure. In some cases, the measured signals are integrated with respect to time to determine the time averaged amount of material elements bound to the surface.
摘要翻译: 用于进行测定的方法和装置,其涉及在谐振装置的表面的实质区域上结合具有多个键的材料元件,从而建立归一化曝光。 所述方法和装置还涉及控制在第一时间段内施加到材料元件的外部影响,并且在第二时间段内测量指示与表面相关的材料元素量相对于 归一化曝光 在一些情况下,测量的信号相对于时间被积分,以确定与表面结合的材料元素的时间平均量。
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公开(公告)号:US20070103776A1
公开(公告)日:2007-05-10
申请号:US11268998
申请日:2005-11-08
申请人: Ronald Cok , Michael Miller , Michael Murdoch
发明人: Ronald Cok , Michael Miller , Michael Murdoch
IPC分类号: G03B21/56
CPC分类号: G03B21/56
摘要: A curved display device comprising a continuous, curved, concave viewing surface having a surface width W greater than or equal to 48 cm and less than or equal to 200 cm, and wherein a distance D from the center of a straight line segment which connects the centers of the display edges in the width dimension, to the center of the display surface in the horizontal dimension is less than or equal to ((0.215W)−6.5).
摘要翻译: 一种弯曲的显示装置,包括具有大于或等于48厘米且小于或等于200厘米的表面宽度W的连续的弯曲的凹形观察表面,并且其中距离直线段的中心的距离D, 宽度尺寸显示边缘的中心在水平尺寸的显示表面的中心小于或等于((0.215W)-6.5)。
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