摘要:
A new machine learning technique is herein disclosed which generalizes the support vector machine framework. A separating hyperplane in a separating space is optimized in accordance with generalized constraints which are dependent upon the clustering of the input vectors in the dataset.
摘要:
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
摘要:
Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要:
A spherical magnet is formed as a hollow sphere having a fluid tight outer surface of a first magnetic pole and an inner surface having a second magnetic pole that is magnetically opposite the first pole. A plurality of individual thin flexible rectangular plate magnets are arranged as a continuous outer layer of the spherical magnet. Each individual plate magnet has four sides, an inner magnetic portion and an outer non-magnetic portion that extends around all four sides of the magnetic portion. Each inner magnetic portion includes a first face disposed on the outer surface and having the first pole and a second face opposite the first face, disposed on the inner surface and having the second pole.
摘要:
A bone dowel is disclosed that may be used for connecting two or more bone components. The bone dowel may have three dowel sections positioned between a base and a tip with a conical upper section. Each bone dowel section may be positioned in axial alignment adjacent at least one other bone dowel section wherein the diameters decrease over the length of the bone dowel from the base to the tip.
摘要:
The present technology is directed to a dilator centering device and assemblies and methods using same. In particular, a dilator centering device in accordance with the disclosed technology can be used with a sheath hub assembly. In one embodiment, a dilator centering device includes a lumen capable of receiving a dilator shaft and centering a dilator shaft with respect to the sheath hub as the dilator shaft enters the sheath hub. In one embodiment, the dilator centering device can be attached to the sheath hub during manufacturing or it can be attached at the use site. In one embodiment, the dilator centering device can be integrated with and non-removable from the sheath hub. The embodiments disclosed herein are illustrative and do not limit the scope and spirit of the disclosed technology.
摘要:
Controlled localized defect paths for resistive memories are described, including a method for forming controlled localized defect paths including forming a first electrode forming a metal oxide layer on the first electrode, masking the metal oxide to create exposed regions and concealed regions of a surface of the metal oxide, and altering the exposed regions of the metal oxide to create localized defect paths beneath the exposed regions.
摘要:
A shower head includes a push-button operated rotatable valve having a plurality of positions including; a first position in which the shower head allows water to flow to a first function, a second position radially offset from the first position in which the shower head allows water to flow to a second function, a third position radially offset from the first position and the second position and to the first position, in which the shower head allows water to flow trickle through the shower head.
摘要:
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
摘要:
The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.