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公开(公告)号：US20180085391A1
公开(公告)日：2018-03-29
申请号：US15502368
申请日：2015-08-07
Applicant: ModernaTX, Inc.
Inventor： Axel Bouchon , Eric Yi-Chun Huang
CPC classification number: A61K31/7105 , A61K9/0048 , A61K9/0051 , A61K9/1271 , A61K38/00 , A61K47/10 , A61K47/24 , A61K48/005 , A61K48/0066 , A61K48/0075
Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of ophthalmic disease or conditions.
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公开(公告)号：US20250041393A1
公开(公告)日：2025-02-06
申请号：US18706652
申请日：2022-11-01
Applicant: MODERNATX, INC.
Inventor： Eric Yi-Chun Huang , Paul Stein , Laurie Kenney , Michelle Dutra , Myoungjoo Kim , Pranitha Vangala
Abstract: The disclosure features lipid nanoparticle (LNP) compositions ITB6 molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding ITB6 polypeptides. The LNP compositions of the present disclosure can reprogram dendritic cells, suppress T cells and/or induce immune tolerance in vivo.
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公开(公告)号：US20240398927A9
公开(公告)日：2024-12-05
申请号：US17683171
申请日：2022-02-28
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Axel Bouchon , Eric Yi-Chun Huang
IPC: A61K39/145 , A61K9/00 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K39/12 , A61K39/155 , A61K39/39 , A61K48/00 , C12N7/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号：US20230112857A1
公开(公告)日：2023-04-13
申请号：US17758520
申请日：2021-01-08
Applicant: ModernaTX, Inc.
Inventor： Eric Yi-Chun Huang , Sze-Wah Tse , Seymour De Picciotto
IPC: A61K48/00 , C12N15/88 , C07K14/705 , A61K9/127 , A61P37/06
Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising immune checkpoint inhibitor molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding immune checkpoint inhibitor polypeptides, e.g., PD-L1, PD-L2, B7-H3, B7-H4, CD200 Galectin 9 and CTLA4. The LNP compositions of the present disclosure can reprogram dendritic cells, suppress T cells and/or induce immune tolerance in vivo.
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公开(公告)号：US20220193223A1
公开(公告)日：2022-06-23
申请号：US17683171
申请日：2022-02-28
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Axel Bouchon , Eric Yi-Chun Huang
IPC: A61K39/145 , A61K48/00 , A61K31/7105 , A61K39/12 , A61K39/39 , A61K9/00 , A61K39/155 , A61K9/127 , A61K9/51 , C12N7/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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Patent Agency Ranking
公开(公告)号：US20220080038A9
公开(公告)日：2022-03-17
申请号：US16493986
申请日：2018-03-15
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kerim Babaoglu , Jessica Anne Flynn , Lan Zhang , David Nickle
IPC: A61K39/145
Abstract: The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.
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公开(公告)号：US11235052B2
公开(公告)日：2022-02-01
申请号：US16853973
申请日：2020-04-21
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Sunny Himansu , Eric Yi-Chun Huang , Tal Zaks , Sayda Mahgoub Elbashir
IPC: A61K39/12 , A61K39/015 , A61P11/00 , A61K39/39 , A61K39/42 , A61K9/00 , A61K9/127 , A61K9/51 , A61K48/00 , A61K39/00
Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.
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公开(公告)号：US20200368343A1
公开(公告)日：2020-11-26
申请号：US16897859
申请日：2020-06-10
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu
IPC: A61K39/12 , A61K9/00 , C07K16/28 , C07K14/005 , C07K16/10 , A61K9/14 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/28 , C12N7/00 , A61P31/12 , A61P31/14 , A61K9/51
Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US10702597B2
公开(公告)日：2020-07-07
申请号：US16009880
申请日：2018-06-15
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kapil Bahl , Tal Zaks , Sunny Himansu , Sayda Mahgoub Elbashir
IPC: A61K39/12 , C07K14/005 , A61K9/14 , A61K9/00 , C07K16/28 , C07K16/10 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/28 , C12N7/00 , A61P31/12 , A61P31/14 , A61K9/51 , A61K39/00
Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US10238731B2
公开(公告)日：2019-03-26
申请号：US15674591
申请日：2017-08-11
Applicant: ModernaTX, Inc.
Inventor： Giuseppe Ciaramella , Sunny Himansu , Eric Yi-Chun Huang , Tal Zaks , Sayda Mahgoub Elbashir
IPC: A61K39/12 , A61K48/00 , A61K39/39 , A61K39/42 , A61K9/00 , A61K9/127 , A61K9/51 , A61K39/015 , A61K39/00
Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.
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