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公开(公告)号：US5955507A
公开(公告)日：1999-09-21
申请号：US459975
申请日：1995-06-02
申请人： Graham J. Durant , Lain-Yen Hu , Sharad Magar
发明人： Graham J. Durant , Lain-Yen Hu , Sharad Magar
IPC分类号： C07D521/00 , A61K31/155 , A61P9/08 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07C279/18 , C07C317/42 , C07C323/44
CPC分类号： C07C279/18 , C07C323/44
摘要： The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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公开(公告)号：US5922772A
公开(公告)日：1999-07-13
申请号：US458809
申请日：1995-06-02
申请人： Graham J. Durant , Lain-Yen Hu , Sharad Magar
发明人： Graham J. Durant , Lain-Yen Hu , Sharad Magar
IPC分类号： C07D521/00 , A61K31/155 , A61P9/08 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07C279/18 , C07C317/42 , C07C323/44
CPC分类号： C07C279/18 , C07C323/44
摘要： The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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公开(公告)号：US5637623A
公开(公告)日：1997-06-10
申请号：US468813
申请日：1995-06-06
申请人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew G. Knapp , Lee D. Margolin
发明人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew G. Knapp , Lee D. Margolin
IPC分类号： A61K31/15 , A61K31/155 , A61K31/16 , A61K31/17 , A61K31/275 , A61K31/277 , A61K31/34 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/39 , A61K31/40 , A61K31/403 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/53 , A61K31/54 , A61K31/655 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , C07C279/04 , C07C279/16 , C07C279/18 , C07C279/22 , C07C281/16 , C07C281/18 , C07D209/00 , C07D217/22 , C07D239/42 , C07D241/20 , C07D263/48 , C07D277/82 , C07D333/36 , G01N33/58
CPC分类号： C07C281/16 , A61K31/155 , A61K31/17 , A61K31/275 , A61K31/277 , A61K31/34 , A61K31/37 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/655 , C07C279/16 , C07C2101/14 , C07C2103/20 , C07C2103/74
摘要： Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
摘要翻译： 公开了神经递质释放的调节剂，包括取代的胍，N“ - 氨基胍和N，N'N”，N“ - 四取代肼二甲酰亚胺酰胺及其药物组合物。 还公开了涉及使用这种神经递质释放调节剂来治疗或预防以释放过量或不适当水平的神经递质为特征的病理生理学病症的方法。 还公开了选择性抑制谷氨酸释放的化合物的筛选测定。 还公开了阻断哺乳动物神经细胞中电压敏感的钠和钙通道的方法。
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公开(公告)号：US20060252796A1
公开(公告)日：2006-11-09
申请号：US11415935
申请日：2006-05-02
申请人： Stephen Barrett , Victor Fedij , Lain-Yen Hu , Donna Iula , Bruce Lefker , Raj Raheja , Karen Sexton , Jennifer Van Camp
发明人： Stephen Barrett , Victor Fedij , Lain-Yen Hu , Donna Iula , Bruce Lefker , Raj Raheja , Karen Sexton , Jennifer Van Camp
IPC分类号： A61K31/445 , A61K31/4015
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US06174924B1
公开(公告)日：2001-01-16
申请号：US08462013
申请日：1995-06-05
申请人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
发明人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
IPC分类号： A61K31155
CPC分类号： C07C323/43 , A61K31/155 , A61K31/405 , A61K31/445 , C07C279/04 , C07C279/18 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/12 , C07C2603/18 , C07C2603/20 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/74 , C07D209/08 , C07D209/90 , C07D209/92 , C07D217/06 , C07D277/62 , C07D285/10 , C07D295/215 , C07D317/58 , C07D471/04
摘要： The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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公开(公告)号：US6153604A
公开(公告)日：2000-11-28
申请号：US458803
申请日：1995-06-02
申请人： Graham J. Durant , Sharad Magar , Lain-Yen Hu
发明人： Graham J. Durant , Sharad Magar , Lain-Yen Hu
IPC分类号： C07D215/40 , A61K31/155 , A61K31/47 , A61P3/08 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07C271/18 , C07C279/18 , C07C317/42 , C07C323/44 , C07D217/02 , A61K31/18 , A61K31/445 , A61K31/655
CPC分类号： C07C271/18 , C07C317/42 , C07C323/44 , C07D217/02
摘要： The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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公开(公告)号：US6147063A
公开(公告)日：2000-11-14
申请号：US458741
申请日：1995-06-02
申请人： Graham J. Durant , Sharad Magar , Lain-Yen Hu
发明人： Graham J. Durant , Sharad Magar , Lain-Yen Hu
IPC分类号： C07D215/40 , A61K31/155 , A61K31/47 , A61P3/08 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07C271/18 , C07C279/18 , C07C317/42 , C07C323/44 , C07D217/02 , A61K31/18 , A61K31/445 , A61K31/655
CPC分类号： C07C271/18 , C07C317/42 , C07C323/44 , C07D217/02
摘要： The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
摘要翻译： 本发明提供了治疗上有用的以下分子式的取代胍，以及使用或包含一种或多种此类胍的治疗方法和药物组合物。
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公开(公告)号：US5741661A
公开(公告)日：1998-04-21
申请号：US463686
申请日：1995-06-05
申请人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
发明人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
IPC分类号： A61K31/155 , A61K31/37 , A61K31/4453 , C12Q1/02 , A23J3/00 , A01N37/52
CPC分类号： A61K31/155 , A61K31/37 , A61K31/4453 , C07C2103/20
摘要： Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
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公开(公告)号：US5681861A
公开(公告)日：1997-10-28
申请号：US466263
申请日：1995-06-06
申请人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
发明人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
IPC分类号： A61K31/15 , A61K31/155 , A61K31/16 , A61K31/17 , A61K31/275 , A61K31/277 , A61K31/34 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/39 , A61K31/40 , A61K31/403 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/53 , A61K31/54 , A61K31/655 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , C07C279/04 , C07C279/16 , C07C279/18 , C07C279/22 , C07C281/16 , C07C281/18 , C07D209/00 , C07D217/22 , C07D239/42 , C07D241/20 , C07D263/48 , C07D277/82 , C07D333/36 , G01N33/58
CPC分类号： C07C281/16 , A61K31/155 , A61K31/17 , A61K31/275 , A61K31/277 , A61K31/34 , A61K31/37 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/655 , C07C279/16 , C07C2101/14 , C07C2103/20 , C07C2103/74
摘要： Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
摘要翻译： 公开了神经递质释放的调节剂，包括取代的胍，N“ - 氨基胍和N，N'N”，N“ - 四取代肼二甲酰亚胺酰胺及其药物组合物。 还公开了涉及使用这种神经递质释放调节剂来治疗或预防以释放过量或不适当水平的神经递质为特征的病理生理学病症的方法。 还公开了选择性抑制谷氨酸释放的化合物的筛选测定。 还公开了阻断哺乳动物神经细胞中电压敏感的钠和钙通道的方法。
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公开(公告)号：US5672608A
公开(公告)日：1997-09-30
申请号：US343829
申请日：1994-11-22
申请人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
发明人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
IPC分类号： A61K31/15 , A61K31/155 , A61K31/16 , A61K31/17 , A61K31/275 , A61K31/277 , A61K31/34 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/39 , A61K31/40 , A61K31/403 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/53 , A61K31/54 , A61K31/655 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , C07C279/04 , C07C279/16 , C07C279/18 , C07C279/22 , C07C281/16 , C07C281/18 , C07D209/00 , C07D217/22 , C07D239/42 , C07D241/20 , C07D263/48 , C07D277/82 , C07D333/36 , G01N33/58 , A61K31/405 , A61K31/36
CPC分类号： C07C281/16 , A61K31/155 , A61K31/17 , A61K31/275 , A61K31/277 , A61K31/34 , A61K31/37 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/655 , C07C279/16 , C07C2101/14 , C07C2103/20 , C07C2103/74
摘要： Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
摘要翻译： 公开了神经递质释放的调节剂，包括取代的胍，N“ - 氨基胍和N，N'N”，N“ - 四取代肼二甲酰亚胺酰胺及其药物组合物。 还公开了涉及使用这种神经递质释放调节剂来治疗或预防以释放过量或不适当水平的神经递质为特征的病理生理学病症的方法。 还公开了选择性抑制谷氨酸释放的化合物的筛选测定。 还公开了阻断哺乳动物神经细胞中电压敏感的钠和钙通道的方法。
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