公开(公告)号：US06622268B2

公开(公告)日：2003-09-16

申请号：US09725221

申请日：2000-11-29

申请人： Thomas J. Holman

发明人： Thomas J. Holman

IPC分类号： H03M1303

CPC分类号： H03M13/03 ,  H03M13/01

摘要： System and methods for propagating error status over an error checking and correcting (ECC) protected channel. A first device receives data and an error status associated with the data. The first device generates check bits for the data based on a first ECC code and combines the check bits with the data to form one or more code words. The first device sends the code words across the channel where the first device inserts a triple error into a nibble of at least one codeword sent if the error status indicated an uncorrectable error. A second device connected to the channel receives the code words sent across the channel. The second device detects triple errors within a nibble of any code word and any other single error in the code word using a second ECC code, where the second ECC code is the first ECC code with columns for check bits inserted.

公开(公告)号：US06416529B1

公开(公告)日：2002-07-09

申请号：US09528613

申请日：2000-03-20

申请人： Thomas J. Holman ,  Louis G. Ellis ,  Gregory K. Olson ,  Linda R. Lorentzen Cornelius ,  Richard J. Traxler ,  Scott M. Hanson ,  Tracee E. J. Eidenschink ,  Sonja J. K. Williams

发明人： Thomas J. Holman ,  Louis G. Ellis ,  Gregory K. Olson ,  Linda R. Lorentzen Cornelius ,  Richard J. Traxler ,  Scott M. Hanson ,  Tracee E. J. Eidenschink ,  Sonja J. K. Williams

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61F2/0095 ,  A61F2/958 ,  A61F2002/9583 ,  A61M2025/1081

摘要： A balloon catheter is provided having an expandable distal portion and balloon protector means comprising a first removable sleeve having a variable inner diameter to ease sliding the first sleeve over the balloon, and an optional second removable (outer) sleeve positioned over the inner sleeve, the second (outer) sleeve having a constrictive relationship with the first (inner) sleeve, said first and second sleeves being removed prior to use of the catheter. A stent delivery system is provided to facilitate introduction and placement of a stent, and includes a catheter having an expandable distal portion constructed and arranged for expanding the outer diameter of the catheter from a contracted state to an expanded state, said distal portion further comprising a balloon and at least one dam over which the balloon extends, and a stent positioned around the distal portion of the catheter around the balloon or gripper linear control device, said stent having a contracted condition, being sized in the contracted condition to closely surround the balloon in the contracted state, and being expandable to an expanded condition; a first removable (inner) sleeve in the region of the distal portion of the catheter positioned around the stent (and between the damns where the device comprises two dams), said first sleeve comprising a first end, a second end and a variable inner diameter to ease sliding the sleeve over the balloon and stent; an optional second removable (outer) sleeve positioned over the stent, first sleeve and at least one dam, said second (outer) sleeve having a constrictive relationship with the first (inner) sleeve, whereby when compressed by the outer sleeve, the inner sleeve will have an inner diameter approximately equal to or less than the outer profile of the collapsed balloon over the at least one dam, said first and second sleeves being removed prior to use of the stent delivery system and release of the stent by expansion of the balloon.

公开(公告)号：US06345009B1

公开(公告)日：2002-02-05

申请号：US09658465

申请日：2000-09-08

申请人： Ely K. Tsern ,  Richard M. Barth ,  Paul G. Davis ,  Craig E. Hampel ,  Thomas J. Holman ,  Andrew V. Anderson

发明人： Ely K. Tsern ,  Richard M. Barth ,  Paul G. Davis ,  Craig E. Hampel ,  Thomas J. Holman ,  Andrew V. Anderson

IPC分类号： G11C700

CPC分类号： G11C11/406

摘要： A memory system includes a set of memory devices. An interconnect structure links the set of memory devices to one another. A memory controller is connected to the interconnect structure. The memory controller is configured to apply a control signal to the interconnect structure such that a specified subset of the set of memory devices performs a refresh operation.

摘要翻译： 存储器系统包括一组存储器件。 互连结构将存储器件集合彼此连接。 存储器控制器连接到互连结构。 存储器控制器被配置为将控制信号施加到互连结构，使得该组存储器件的指定子集执行刷新操作。

公开(公告)号：US5441516A

公开(公告)日：1995-08-15

申请号：US206139

申请日：1994-03-03

申请人： Lixiao Wang ,  Martin R. Willard ,  Thomas T. Tran ,  Roger Hastings ,  Dale F. Schmaltz ,  Thomas J. Holman

发明人： Lixiao Wang ,  Martin R. Willard ,  Thomas T. Tran ,  Roger Hastings ,  Dale F. Schmaltz ,  Thomas J. Holman

IPC分类号： A61B17/22 ,  A61B18/08 ,  A61B19/00 ,  A61F2/00 ,  A61F2/82 ,  A61F2/88 ,  A61F7/00 ,  A61F7/12 ,  A61M29/00

CPC分类号： A61F2/82 ,  A61B17/22 ,  A61F2/88 ,  A61F2/95 ,  A61B18/082 ,  A61B2017/22001 ,  A61B90/39 ,  A61F2002/3008 ,  A61F2002/30093 ,  A61F2002/9517 ,  A61F2007/0054 ,  A61F2210/0019 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61F2250/0098 ,  A61F7/12

摘要： Apparatus including a spiral coil body as a stent for temporarily supporting a body vessel internally, the spiral coil body being adjustable in diameter by relative rotation of at least one of the ends of the body from a proximal location.

摘要翻译： 包括螺旋线圈体作为用于在内部临时支撑体体的支架的螺旋线圈体，所述螺旋线圈体通过所述主体的至少一个端部与近侧位置的相对旋转而可直径调节。

公开(公告)号：US5352215A

公开(公告)日：1994-10-04

申请号：US935856

申请日：1992-08-26

申请人： Scott P. Thome ,  Thomas J. Holman

发明人： Scott P. Thome ,  Thomas J. Holman

IPC分类号： A61M39/10 ,  A61M25/00

CPC分类号： A61M39/10 ,  A61M2039/1077 ,  A61M2039/1083 ,  Y10S425/058

摘要： An improved Y-adapter in which the lumen extending through the side arm is formed along the arc of a circle and smoothly merges into the lumen extending through the central arm, such that a catheter or guide wire can be smoothly inserted through the side arm of the Y-adapter into the central arm and then twisted and manipulated without distortion.

摘要翻译： 一种改进的Y型适配器，其中延伸穿过侧臂的内腔沿着圆弧形成并且平滑地融合到延伸穿过中心臂的内腔中，使得导管或导丝可以平滑地穿过侧臂 将Y型适配器插入中央臂，然后扭曲和操纵而不变形。

公开(公告)号：US09011516B2

公开(公告)日：2015-04-21

申请号：US11763740

申请日：2007-06-15

申请人： Jan Weber ,  Thomas J. Holman ,  Tracee Eidenschink

发明人： Jan Weber ,  Thomas J. Holman ,  Tracee Eidenschink

IPC分类号： A61F2/844 ,  A61F2/01 ,  A61F2/06 ,  A61F2/82

CPC分类号： A61F2/013 ,  A61F2/06 ,  A61F2/82 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0078 ,  A61F2250/003

摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes an elongated hollow body formed of a polymeric matrix containing one or more regions of a pre-determined weight percent of carbon nanotubes in general alignment in a pre-determined orientation. The medical device can have a compressed state with a first transverse dimension and an expanded state with a second relatively greater transverse dimension.

摘要翻译： 描述医疗装置，例如内用假体，以及制造装置的方法。 在一些实施方案中，医疗装置包括由聚合物基质形成的细长中空体，其含有预定重量百分比的碳纳米管的一个或多个区域，以预定方向大致对准。 医疗装置可以具有第一横向尺寸的压缩状态和具有第二较大横向尺寸的膨胀状态。

公开(公告)号：US08672990B2

公开(公告)日：2014-03-18

申请号：US11139253

申请日：2005-05-27

申请人： Thomas J. Holman ,  Jan Weber

发明人： Thomas J. Holman ,  Jan Weber

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2/90 ,  A61F2/954 ,  A61M25/10 ,  A61M2025/1081 ,  A61M2025/1084

摘要： A medical device having a catheter shaft having a distal portion and a proximal portion, a medical balloon co-axially mounted on the distal portion of the catheter shaft and a tubular mesh wrapped around the balloon, wherein the mesh strengthens and reinforced the balloon and may be manipulation to dictate the shape of the balloon and to squeeze the balloon down onto the catheter shaft during deflation of the balloon.

摘要翻译： 一种具有导管轴的医疗装置，其具有远侧部分和近端部分，同轴地安装在导管轴的远端部分上的医疗气囊和缠绕在气囊上的管状网状物，其中，网状物加强并加强气囊，并且可以 操纵以指示气球的形状并且在气球收缩期间将气囊向下挤压到导管轴上。

公开(公告)号：US08298179B2

公开(公告)日：2012-10-30

申请号：US11020540

申请日：2004-12-22

申请人： Thomas J. Holman ,  Afsar Ali

发明人： Thomas J. Holman ,  Afsar Ali

IPC分类号： A61M25/10

CPC分类号： A61M25/1034 ,  A61M25/10 ,  A61M2025/1093 ,  Y10T156/10

摘要： A catheter assembly comprises at least one catheter shaft and a balloon. The catheter shaft comprises a substantially cylindrical portion and at least one tapered portion. The tapered portion forms an angle with the cylindrical portion of about 1 degree to about 25 degrees. At least one of the waists of the balloon is sealingly engaged to the tapered portion.

摘要翻译： 导管组件包括至少一个导管轴和气囊。 导管轴包括基本上圆柱形的部分和至少一个锥形部分。 锥形部分与圆柱形部分形成约1度至约25度的角度。 球囊的至少一个腰部密封地接合到锥形部分。

公开(公告)号：US08048028B2

公开(公告)日：2011-11-01

申请号：US11060093

申请日：2005-02-17

申请人： Daniel J. Horn ,  John Jianhua Chen ,  Jan Weber ,  Thomas J. Holman

发明人： Daniel J. Horn ,  John Jianhua Chen ,  Jan Weber ,  Thomas J. Holman

IPC分类号： A61M25/10

CPC分类号： A61M25/104 ,  A61F2002/9583 ,  A61F2250/0068 ,  A61L29/126 ,  A61M2025/1086

摘要： The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.

摘要翻译： 本发明涉及医用气囊，以及通过在其外表面上形成空隙图案并用诸如纤维或纳米材料（例如纳米管，例如碳纳米管）和基体 材料，例如聚合物。

公开(公告)号：US20110046539A1

公开(公告)日：2011-02-24

申请号：US12939363

申请日：2010-11-04

申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。