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1.发明申请公开(公告)号：US20110046539A1
公开(公告)日：2011-02-24
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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2.发明授权公开(公告)号：US08152759B2
公开(公告)日：2012-04-10
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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3.发明授权公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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4.发明授权公开(公告)号：US08538515B2
公开(公告)日：2013-09-17
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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5.发明申请公开(公告)号：US20080262412A1
公开(公告)日：2008-10-23
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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公开(公告)号：US20060184092A1
公开(公告)日：2006-08-17
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
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7.发明申请Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent 审中-公开包含无机或陶瓷氧化物和治疗剂的医疗装置的涂层公开(公告)号：US20070264303A1
公开(公告)日：2007-11-15
申请号：US11433898
申请日：2006-05-12
申请人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
发明人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
CPC分类号： A61L31/10 , A61L31/088 , A61L31/124 , A61L31/16 , A61L2300/416
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, such as titanium oxide, and a therapeutic agent.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包含无机或陶瓷氧化物如二氧化钛的涂层和治疗剂。
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8.发明申请Coating for Medical Devices Comprising An Inorganic or Ceramic Oxide and a Therapeutic Agent 审中-公开包含无机或陶瓷氧化物和治疗剂的医疗器械的涂层公开(公告)号：US20110189377A1
公开(公告)日：2011-08-04
申请号：US13086033
申请日：2011-04-13
申请人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
发明人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
CPC分类号： A61L31/10 , A61L31/088 , A61L31/124 , A61L31/16 , A61L2300/416
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stem, having a coating comprising an inorganic or ceramic oxide, such as titanium oxide, and a therapeutic agent.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内茎，其具有包含无机或陶瓷氧化物如二氧化钛的涂层和治疗剂。
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公开(公告)号：US20120150286A1
公开(公告)日：2012-06-14
申请号：US13372692
申请日：2012-02-14
申请人： Jan Weber , Liliana Atanasoska , Scott Schewe
发明人： Jan Weber , Liliana Atanasoska , Scott Schewe
CPC分类号： A61L31/16 , A61L31/022 , A61L31/082 , A61L2300/416
摘要： Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed.
摘要翻译： 公开了包含一个或多个生物稳定层（例如生物稳定无机层）和可生物降解的底层结构的内用假体（例如，支架）的医疗装置。
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10.发明申请Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置公开(公告)号：US20080175881A1
公开(公告)日：2008-07-24
申请号：US11654884
申请日：2007-01-18
申请人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
发明人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。 释放区域包含一种或多种聚合物组分。 释放区域还任选地含有一种或多种无机组分。 一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。 一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。
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