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    Process for the preparation of substituted difluorobenzo-1,3-dioxoles
    41.
    发明授权
    Process for the preparation of substituted difluorobenzo-1,3-dioxoles 失效
    制备取代的二氟苯-1,3-二氧杂环戊烯的方法

    公开(公告)号：US5194628A

    公开(公告)日：1993-03-16

    申请号：US583787

    申请日：1990-09-14

    申请人： Peter Ackermann ,  Hans-Ruedi Kanel ,  Bruno Schaub

    发明人： Peter Ackermann ,  Hans-Ruedi Kanel ,  Bruno Schaub

    IPC分类号： C07D317/46 ,  C07D405/04 ,  C07F1/00 ,  C07F1/02 ,  C07F3/00 ,  C07F5/02 ,  C07F7/08 ,  C07F7/10 ,  C07F19/00

    CPC分类号： C07D405/04 ,  C07D317/46 ,  C07F1/00 ,  C07F1/02 ,  C07F19/00 ,  C07F3/00 ,  C07F5/025 ,  C07F7/0814 ,  C07F7/10 ,  Y02P20/55

    摘要： The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R.sup.1 -Z.sup.1 l in which Z.sup.1 is a leaving group, or with an aldehyde produces compounds of formula I ##STR1## wherein R.sup.1 l is --OH, --SH, --CHO, --CN, --COOH, --B(OH).sub.2, --COX, with X being Cl or Br, or is --COOR.sup.2, --SiR.sub.3.sup.2 or --B(OR.sup.2).sub.2, with R.sup.2 being a C.sub.1 -C.sub.12 alcohol moiety without the hydroxy group, wherein R.sup.1 is further --C.sub.n H.sub.2n COOR.sup.2, with n being an integer from 1 to 4, or linear or branched C.sub.1 -C.sub.12 hydroxyalkyl which is unsubstituted or is substituted by --F, --CN, C.sub.1 -C.sub.6 alkoxy, phenyl, fluorophenyl, C.sub.1 -C.sub.4 alkoxy-phenyl, C.sub.1 -C.sub.4 alkylthio-phenyl, C.sub.1 -C.sub.4 alkyl-phenyl, C.sub.1 -C.sub.4 fluoroalkyl-phenyl, nitrophenyl or by cyanophenyl, or wherein R.sup.1 is a benzyl alcohol which is unsubstituted or is substituted by F, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, nitro or by cyano, or is C.sub.1 -C.sub.12 acyl, or wherein R.sup. 1 is a radical of formula II ##STR2## wherein R.sup.5 is --CN, --CF.sub.3, --COOR.sup.2, --CO--NHR.sup.2 or --CONR.sub.2.sup.2, R.sup.3 and R.sup.4 are a direct bond or each is H, or R.sup.3 is H and R.sup.4 independently has the meanings of R.sup.5, or R.sup.3 and R.sup.4 together are --CH.sub.2 --NR.sup.6 --CH.sub.2 --, --CH.sub.2 --NR.sup.6 --CO-- or --CO--NR.sup.6 --CO-- wherein R.sup.6 is the radical of a removable protecting group, or wherein further R.sup.1 is a radical of formula III ##STR3## Insecticides or fungicides can be prepared from the compounds of formula I. 3-(2,2-difluorobenzodioxol-4-yl)-4-cyanopyrrole can be prepared by reacting 4-metallo-2,2-difluorobenzodioxole (III) with an unsaturated nitrile and then with a sulfonylmethyl isocyanide in a one-pot process. The compounds III are novel intermediates.

    摘要翻译： 2,2-二氟苯-1,3-二氧杂环戊烯与（a）碱金属或碱金属化合物反应，然后（b）其中Z1是离去基团或与醛产生的化合物R1-Z1 式I的化合物其中R 1是-OH，-SH，-CHO，-CN，-COOH，-B（OH）2，-COX，X是Cl或Br，或是-COOR 2 ，-SiR 32或-B（OR 2）2，其中R 2是没有羟基的C 1 -C 12醇部分，其中R 1还是-C n H 2n NOR 2，n是1至4的整数，或直链或支链C 1 -C 12羟烷基，其是 或者被-F，-CN，C 1 -C 6烷氧基，苯基，氟苯基，C 1 -C 4烷氧基 - 苯基，C 1 -C 4烷硫基 - 苯基，C 1 -C 4烷基 - 苯基，C 1 -C 4氟烷基 - 苯基，硝基苯基或氰基苯基取代，或其中 R1是未被取代或被F，C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基，C 1 -C 4氟烷基，硝基或氰基取代的苯甲醇，或者是C 1 -C 12酰基，或其中R 1是式 II（II）其中R5是-CN，-CF3，-COOR2，-CO-NHR2 或-CONR 22，R 3和R 4是直接键或各自为H或R 3为H且R 4独立地具有R 5的含义，或者R 3和R 4一起为-CH 2 -NR 6 -CH 2 - ， - CH 2 -NR 6 -CO- 或-CO-NR6-CO-，其中R6是可除去的保护基团的基团，或其中R1是式III的基团。（III）杀虫剂或杀真菌剂可以由式I化合物制备。 （2,2-二氟苯并二氧杂环戊烯-4-基）-4-氰基吡咯可以通过4-金属-2,2-二氟苯并间二氧杂环戊烯（III）与不饱和腈然后与磺酰基甲基异氰化物在一锅法中反应来制备。 化合物III是新的中间体。

    1-(6-phenoxy-2-pyridyl)ethanol emantiomers as pesticides intermediates
    42.
    发明授权
    1-(6-phenoxy-2-pyridyl)ethanol emantiomers as pesticides intermediates 失效
    1-（6-苯氧基-2-吡啶基）乙醇对映异构体作为农药中间体

    公开(公告)号：US4778895A

    公开(公告)日：1988-10-18

    申请号：US36144

    申请日：1987-04-06

    申请人： Eric Francotte ,  Peter Ackermann

    发明人： Eric Francotte ,  Peter Ackermann

    IPC分类号： A01N53/00 ,  C07D213/64 ,  C07D213/643 ,  C07D213/647 ,  C07D213/26 ,  C07D213/30

    CPC分类号： C07D213/643 ,  A01N53/00 ,  C07D213/647

    摘要： The invention relates to enantiomers of 1-(6-phenoxy-2-pyridyl)ethanols of the formula ##STR1## wherein * is (+) or (-) and X and Y are each independently of the other hydrogen, halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.5 alkenyl or C.sub.2 -C.sub.5 alkynyl.The invention also relates to the preparation of these enantiomers and to their use for the preparation of biocidal compounds.

    摘要翻译： 本发明涉及式（I）的1-（6-苯氧基-2-吡啶基）乙醇的对映异构体，其中*是（+）或（ - ），X和Y各自独立地为氢，卤素 ，硝基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4烷氧基，C 2 -C 5烯基或C 2 -C 5炔基。 本发明还涉及这些对映异构体的制备及其在制备杀生物剂中的用途。

    Triorganotin hydantoin compounds, and the use thereof for combating insects and acarids
    43.
    发明授权
    Triorganotin hydantoin compounds, and the use thereof for combating insects and acarids 失效
    三有机锡乙内酰脲化合物及其用于防治昆虫和螨虫的用途

    公开(公告)号：US4486424A

    公开(公告)日：1984-12-04

    申请号：US432479

    申请日：1982-10-04

    申请人： Wolfgang Wehner ,  Peter Ackermann

    发明人： Wolfgang Wehner ,  Peter Ackermann

    IPC分类号： A01N55/04 ,  C07F7/22

    CPC分类号： C07F7/2284 ,  A01N55/04

    摘要： Triorganotin hydantoin compounds of the formula ##STR1## wherein R is C.sub.1 -C.sub.8 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, phenyl or ##STR2## R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.8 -alkyl, phenyl, hydroxyphenyl, or together they are C.sub.5 -C.sub.7 -alkylene or oxygen,X is oxygen or sulfur, andY is hydrogen or --Sn--(R).sub.3, as well as a process for producing these compounds, and the use thereof for combating pests are described.

    摘要翻译： 式（Ⅰ）的三有机锡乙内酰脲化合物其中R是C 1 -C 8烷基，C 5 -C 8环烷基，苯基或者R 1和R 2各自是氢，C 1 -C 8 - 烷基，苯基，羟基苯基或 它们一起是C5-C7-亚烷基或氧，X是氧或硫，Y是氢或-Sn-（R）3），以及这些化合物的制备方法及其用于防治害虫的用途。

    Cyclopropanecarboxylic acid esters and use thereof in pest control
    44.
    发明授权
    Cyclopropanecarboxylic acid esters and use thereof in pest control 失效
    环丙烷羧酸酯及其在害虫防治中的应用

    公开(公告)号：US4378372A

    公开(公告)日：1983-03-29

    申请号：US350451

    申请日：1982-02-19

    申请人： Peter Ackermann ,  Laurenz Gsell ,  Rudolf Wehrli

    发明人： Peter Ackermann ,  Laurenz Gsell ,  Rudolf Wehrli

    IPC分类号： A01N53/00 ,  A01N53/08 ,  C07C69/743 ,  C07C121/75

    CPC分类号： A01N53/00

    摘要： The invention relates to cyclopropanecarboxylic acid esters of the formula ##STR1## wherein X.sub.1 is methyl or halogen, R.sub.1 is hydrogen, cyano, --CSNH.sub.2, allenyl, C.sub.2 -C.sub.3 alkenyl or C.sub.2 -C.sub.3 alkynyl, and R.sub.2 is unsubstituted or substituted alkenyl or alkynyl.A process for obtaining these compounds and their use in pest control are also disclosed.

    摘要翻译： 本发明涉及下式的环丙烷羧酸酯，其中X1为甲基或卤素，R1为氢，氰基，-CSNH2，烯丙基，C2-C3链烯基或C2-C3炔基，R2为未取代或取代的烯基或炔基。 还公开了获得这些化合物及其在害虫防治中的用途的方法。

    Process for producing optically active 2-(2,2-dihalogenovinyl)-cyclopropane-1-carboxylic acids substituted in the 3-position, and derivatives thereof, as well as novel 4-(2,2,2-trihalogenoethyl)-cyclobutane-1-sulfonic acid salts
    48.
    发明授权
    Process for producing optically active 2-(2,2-dihalogenovinyl)-cyclopropane-1-carboxylic acids substituted in the 3-position, and derivatives thereof, as well as novel 4-(2,2,2-trihalogenoethyl)-cyclobutane-1-sulfonic acid salts 失效
    3-位取代的光学活性2-（2,2-二卤代乙酰基） - 环丙烷-1-羧酸及其衍生物的方法，以及新的4-（2,2,2-三卤代乙基） - 环丁烷 - 1-磺酸盐

    公开(公告)号：US4299967A

    公开(公告)日：1981-11-10

    申请号：US103983

    申请日：1979-12-17

    申请人： John G. Dingwall ,  Hans Greuter ,  Pierre Martin ,  Peter Ackermann ,  Laurenz Gsell

    发明人： John G. Dingwall ,  Hans Greuter ,  Pierre Martin ,  Peter Ackermann ,  Laurenz Gsell

    IPC分类号： C07C69/74 ,  C07B31/00 ,  C07B57/00 ,  C07C45/45 ,  C07C45/54 ,  C07C45/67 ,  C07C51/00 ,  C07C51/48 ,  C07C61/15 ,  C07C61/40 ,  C07C67/00 ,  C07C69/635 ,  C07C69/743 ,  C07C253/00 ,  C07C255/38 ,  C07C255/39 ,  C07C255/53 ,  C07C301/00 ,  C07C303/10 ,  C07C303/32 ,  C07C309/25 ,  C07C313/00 ,  C07C321/24 ,  C07D307/42 ,  C07D307/45 ,  C07D333/04 ,  C07D333/16 ,  C07D333/32 ,  C07C51/487 ,  C07C67/60

    CPC分类号： C07C45/67 ,  C07C309/00 ,  C07C45/45 ,  C07C45/54 ,  C07C51/00

    摘要： There is described a new process for the preparation of optically active 2-(2',2'-dihalogenovinyl)-cyclopropane-1-carboxylic acids substituted in the 3 position, and derivatives thereof. A racemate of certain cyclobutanones is reacted with a sulfurous acid salt of an optically active base to obtain a mixture of diastereomeric 4-2-(2',2',2'-trihalogenoethyl)-cyclobutane-1-sulfonic acid salts; this mixture is then separated into the pure diastereomeric sulfonic acid salts. Either the pure diastereomeric sulfonic acid salts are converted directly to the desired optically active products, or the optically active cyclobutanones obtained from the pure diastereomeric sulfonic acids salts by decomposition is converted, in the presence of a base to the desired product. Optionally, the product, optically active 2-(2',2'-dihalogenovinyl)-cyclopropane-1-carboxylic acids can be converted to their 1',2'-dibromo derivatives. SUDETAILED DISCLOSUREThe present invention relates to a novel process for the preparation of optically active 2-(2',2'-dihalogenovinyl)-cyclopropane-1-carboxylic acids substituted in the 3-position, and derivatives thereof, and also to novel 4-(2',2',2'-trihalogenoethyl)-cyclobutane-1-sulfonic acid salts. The said cyclopropanecarboxylic acids and their derivatives are valuable starting materials for the preparation of agents for pest control, especially insecticides, or can be employed direct as agents for pest control.It is generally known that in the case of biologically active chemical substances with an optically active centre, as a rule only one of the two possible mirror images is biologically active, but the other is inactive.The known insecticidal pyrethroids are chemical substances which possess several such optically active centres. The literature [cf. M. Elliott: Synthetic Pyrethroids, ACS Symposium Series 42, Am. Chem. Soc. 2-9 (1977)] shows that in this case also the configuration at these centres is decisive in determining the insecticidal activity. Therefore, there is an urgent need for simple economical processes which enable pyrethroids to be synthesised with the optimum effective (insecticidal) configuration. The result of this is that only the biologically active components of a pyrethroid preparation are used. The amounts applied and the pollution of the environment are thus far lower than in the case of the use of pyrethroid preparations which also contain less active or entirely inactive isomers.Various processes for the preparation of optically active 2-(2',2'-dihalogenovinyl)-3,3-dimethylcyclopropane-1-carboxylic acids have been disclosed in the literature, but these processes are not able to meet the above demands in all respects. Japanese Published Specifications Nos. 50-131,953, 51-36,411 and 51-143,647 disclose processes for resolving the racemates of trans-2-(2',2'-dichlorovinyl)-3,3-dimethyl-cyclopropanecarboxylic acid or mixtures of the trans- and cis-acids by reaction with specific optically active amines and decomposition of the resulting pure diastereomeric salts. Furthermore, it has been disclosed in German Offenlegungsschrift No. 2,628,477 that optically active 2-(2',2'-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylic acids which have the undesired, that is to say biologically less active, configuration, especially the (-)-trans-isomer, can be racemised by exposure to UV light in the presence of photosensitisers. However, the yields of the desired racemate are low and, moreover, the proportion of trans-acid in this product is very predominant, so that this process is not suitable for the preparation of cis-acids, which for certain applications display a greater activity and are therefore particularly preferred.According to British Pat. No. 1,446,304, optically active 2-(2',2'-dihalogenovinyl)-3,3-dimethylcyclopropanecarboxylic acids and their alkyl esters can also be prepared by the Wittig reaction, using optically active caronaldehyde derivatives as the starting materials. The optically active caronaldehyde derivatives required for this purpose are, however, accessible only with difficulty, in that they have to be prepared by ozonolysis, either from naturally occurring chrysanthemumic acid, which is not obtainable in any desired amount, or from synthetic chrysanthemumic acid. On racemisation of the acid or of derivatives thereof having the undesired configuration, high proportions of products with the transconfiguration are formed.Finally, according to Japanese Published Specification No. 50-160,241, optically active cyclopropanecarboxylic acid esters can also be prepared by reacting suitable olefins with ethyl diazoacetate in the presence of optically active catalysts (carbene addition). However, the yields of optically active cyclopropanecarboxylic acid esters are unsatisfactory. Moreover, health risks and risks of accident are associated with the handling of the ethyl diazoacetate required for the reaction.A process has now been found which enables optically active 2-(2',2'-dihalogenovinyl)-cyclopropanecarboxylic acids substituted in the 3-position, and derivatives thereof, to be rendered accessible, with high proportions of cis-isomers, in a simpler and more economical manner and avoiding the above disadvantages.The invention thus relates to a process for the preparation of optically active cyclopropanecarboxylic acid derivatives of the formula I or I' ##STR1## in which X is chlorine or bromine, one of the radicals R.sub.1 and R.sub.2 is methyl and the other is hydrogen or methyl, or R.sub.1 and R.sub.2 together are alkylene having 2-4 carbon atoms, and R is hydrogen, alkyl having 1-4 carbon atoms or a group (a) ##STR2## in which R.sub.3 is oxygen, sulfur or vinylene, R.sub.4 is hydrogen, methyl, benzyl, phenoxy, 4-methylphenoxy, 4-chlorophenoxy, 4-fluorophenoxy or phenylmercapto, R.sub.5 is hydrogen, fluorine, chlorine or methyl and R.sub.6 is hydrogen, cyano or ethynyl, by converting a racemate of a cyclobutane of the formula II ##STR3## in which X, R.sub.1 and R.sub.2 are as defined under formula I and Y is chlorine, bromine or a group --OSO.sub.2 R', in which R' is alkyl, halogenoalkyl, benzyl, naphthyl or substituted or unsubstituted phenyl, by reaction with a sulfurous acid salt of an optically active base A, to a mixture of diastereomeric sulfonic acid salts of the formula III ##STR4## in which X, R.sub.1, R.sub.2 and Y are as defined and A is an optically active base, separating this mixture into the pure diastereomeric sulfonic acid salts of the formula III and converting either the pure diastereomeric sulfonic acid salts of the formula III direct, or the optically active cyclobutanones of the formula II obtained from the said salts by decomposition, in the presence of a base to an optically active cyclopropanecarboxylic acid derivative of the formula I and, if desired, converting the latter by bromination to an optically active cyclopropanecarboxylic acid derivative of the formula I'.The reaction of the racemates of cyclobutanones of the formula II with a sulfurous acid salt of an optically active base A is advantageously carried out in the presence of an inert organic solvent at temperatures between about 0.degree. C. and 100.degree. C. and preferably between about 20.degree. and 60.degree. C.Examples of suitable inert organic solvents are aliphatic, cycloaliphatic or aromatic hydrocarbons, which can be nitrated or halogenated, such as n-hexane, n-pentane, cyclohexane, benzene, toluene, xylenes, nitrobenzene, chloroform, carbon tetrachloride, trichloroethylene, 1,1,2,2-tetrachloroethane, nitromethane, chlorobenzene, dichlorobenzenes and trichlorobenzenes; lower aliphatic alcohols, for example those having not more than 6 C atoms, such as methanol, ethanol, propanol, isopropanol, butanols and pentanols; aliphatic diols, such as ethylene glycol and diethylene glycol; ethylene glycol monoalkyl and dialkyl ethers and diethylene glycol monoalkyl and dialkyl ethers, each having 1-4 C atoms in the alkyl moieties, such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol dimethyl ether and ethylene glycol diethyl ether, diethylene glycol monomethyl ether and diethylene glycol monoethyl ether, diethylene glycol dimethyl ether and diethylene glycol diethyl ether; cyclic amides, such as N-methyl-2-pyrrolidone, N-acetyl-2-pyrrolidone and N-methyl-.epsilon.-caprolactam; amides of carbonic acid, such as tetramethylurea and dimorpholinocarbonyl; amides of phosphorous acid, of phosphoric acid, of phenylphosphonic acid or of aliphatic phosphonic acids having 1-3 C atoms in the acid moiety, such as phosphoric acid triamide, phosphoric acid tris-(dimethylamide), phosphoric acid trimorpholide, phosphoric acid tripyrrolinide, phosphoric acid bis-(dimethylamide)-morpholide, phosphoric acid dimethylamide-diethylamide-morpolide, phosphorous acid tris-(dimethylamide) and the tetramethyldiamide of methanephosphonic acid; amides of sulfuric acid or of aliphatic or aromatic sulfonic acids, such as tetramethylsulfamide, the dimethylamide of methanesulfonic acid or p-toluenesulfonic acid amide; sulfur-containing solvents, such as organic sulfones and sulfoxides, for example dimethylsulfoxide and sulfolane; aliphatic nitriles, especially alkylnitriles having 2-5 C atoms, such as acetonitrile, propionitrile and butyronitrile; 3-alkoxypropionitriles having 1 or 2 C atoms in the alkoxy moiety, such as 3-methoxypropionitrile and 3-ethoxypropionitrile; aromatic nitriles, in particular benzonitrile; alkyl esters and alkoxyalkyl esters of aliphatic monocarboxylic acids having a total of 2-6 C atoms, such as methyl formate and ethyl formate, methyl acetate, ethyl acetate, n-butyl acetate and isobutyl acetate; cyclic ethers, such as tetrahydrofuran, tetrahydropyran and dioxan; dialkyl ethers, each having 1-4 C atoms in the alkyl moieties, such as diethyl ether, di-n-propyl ether and di-isopropyl ether; and N,N-dialkylamides of aliphatic monocarboxylic acids having 1-3 C atoms in the acid moiety, such as N,N-dimethylformamide, N,N-dimethylacetamide, N,N-diethylacetamide and N,N-dimethylmethoxyacetamide.Preferred solvents are polar solvents, in particular those which are miscible with water, such as aliphatic alcohols, aliphatic diols, ethylene glycol monoalkyl ethers and diethylene glycol monoalkyl ethers, cyclic amides, amides of phosphoric acid or of phosphorous acid, sulfoxides, alkylnitriles, cyclic ethers and N,N-dialkylamides of aliphatic monocarboxylic acids of the abovementioned type, especially methanol, ethanol, propanol, isopropanol, ethylene glycol and diethylene glycol, ethylene glycol monomethyl ether and ethylene glycol monoethyl ether, diethylene glycol monomethyl ether and diethylene glycol monoethyl ether, N-methyl-2-pyrrolidone, phosphoric acid tris-(dimethylamide), phosphorous acid tris-(dimethylamide), dimethylsulfoxide, acetonitrile, tetrahydrofuran, dioxan, N,N-dimethylformamide and N,N-dimethylacetamide.Compounds which can be employed as optically active bases or sulfurous acid salts of an optically active base in the process according to the invention are compounds known per se, especially amines. Examples of suitable optically active bases are: S(+)-2-amino-1-butanol, R(-)-2-aminobutanol, L(+)-threo-2-amino-1-phenyl-1,3-propanediol, (-)-brucine, (+)-quinidine, (-)-quinine, (-)-cinchonidine, (+)-cinchonine, (+)-dehydroabietylamine, (-)-digitonin, (+)-yohimbine, (-)-nicotine and further alkaloids with optically active centres, (-)-ephedrine, (+)-ephedrine, (-)-N-methyl-ephedrine, R(+)-1-naphthyl-1-ethylamine, S(-)-1-naphthyl-1-ethylamine, S(-)-1-phenylethylamine, R(+)-1-phenylethylamine, (+)-pseudoephedrine, (-)-.alpha.-phenyl-.beta.-p-tolylethylamine and (-)- and (+)-threo-1-(p-nitrophenyl)-2-N,N-dimethylaminopropane-1,3-diol. It is also possible to use esters of aminoacids in the optically active form, such as the methyl ester of L-alanine, the ethyl ester of L-leucine, the tert.-butyl ester of L-phenylalanine, the methyl ester of L-methionine and the benzyl ester of L-valine, and also further derivatives of optically active aminoacids.Compounds preferably used as the optically active base A are R(-)-2-amino-1-butanol, (-)-ephedrine, (+)-ephedrine, S(-)-1-phenylethylamine, R(+)-1-phenylethylamine or (+)-threo-1-(p-nitrophenyl)-2-N,N-dimethylaminopropane-1,3-diol or the sulfurous acid salts of these bases.The optically active base A or the sulfurous acid salt of an optically active base A is advantageously employed in an amount of 0.5 to 1.5 mol equivalents, based on the racemic cyclobutanone of the formula II.The sulfurous acid salt of the optically active base A can be employed as such or can be produced in situ. Preferably, the sulfurous acid salt of the optically active base A is produced in situ. For this purpose, the racemic cyclobutanone of the formula II and the optically active base A are dissolved in a water-containing solvent of the abovementioned type and sulfur dioxide is passed into the solution. Water and sulfur dioxide are used in an amount of at least one mol equivalent, based on the optically active base A.The separation of mixtures of diastereomeric salts of the formula III can be carried out by methods known per se. As a rule, separation is effected by fractional crystallisation in a suitable inert organic solvent, especially in water-miscible organic solvents of the abovementioned type and in particular in aqueous methanol, ethanol, acetonitrile, tetrahydrofuran and dioxan.The diastereomeric salts of the formula III are novel compounds and are likewise a subject of the invention.Preferred compounds of the formula III are those in which A has the preferred meaning defined above, X is chlorine or bromine, one of R.sub.1 and R.sub.2 is methyl and the other is hydrogen or methyl, or R.sub.1 and R.sub.2 together are alkylene having 2-3 C atoms, especially ethylene, and Y is chlorine, bromine or a group --OSO.sub.2 R', in which R' is alkyl or halogenoalkyl having 1-4 C atoms, benzyl, phenyl, methylphenyl, nitrophenyl, chlorophenyl or bromophenyl, and in particular compounds of the formula II and III in which A has the preferred meaning defined above and X is chlorine, R.sub.1 and R.sub.2 are each methyl and Y is a group --OSO.sub.2 R', in which R' is methyl, 4-methylphenyl or 4-bromophenyl.Particularly preferred compounds of the formula III are those in which A has the preferred meaning defined above, X and Y independently of one another are chlorine or bromine and one of R.sub.1 and R.sub.2 is methyl and the other is hydrogen or methyl, or R.sub.1 and R.sub.2 together are alkylene having 2-3 C atoms, especially ethylene, and in particular compounds of this type in which R.sub.1 and R.sub.2 are each methyl. Very particularly preferred compounds of the formula III are those in which A has the preferred meaning defined above, R.sub.1 and R.sub.2 are each methyl and X and Y are each chlorine, or X is bromine and Y is chlorine.A diastereoisomeric salt of the formula III can be converted directly, in the presence of a base, to an optically active cyclopropanecarboxylic acid derivative of the formula I. Preferably, however, the optically active cyclobutanone of the formula II is obtained from the pure diastereomeric salt of the formula III, by decomposition in the presence of an acid or of a base, and this cyclobutanone is then converted, in the presence of a base, to an optically active cyclopropanecarboxylic acid derivative of the formula I.The decomposition of the pure diastereomers of the formula III to give an optically active cyclobutanone of the formula II is likewise advantageously carried out in the presence of an inert organic solvent, especially ethanol or acetonitrile, at a temperature of about 30.degree. to 70.degree. C. and preferably in the presence of one mol equivalent of an inorganic or organic proton acid. When the compounds of the formula III are decomposed, the optically active base is also liberated, as well as the cyclobutanone of the formula II. This base can be recovered in very good yield.Examples of suitable inorganic proton acids are hydrogen halide acids, such as HCl, HBr, HF and HI, nitric acid, phosphoric acid and sulfuric acid. Examples of suitable organic proton acids are: sulfinic acids, such as benzenesulfinic acid; aliphatic and substituted or unsubstituted aromatic sulfonic acids, such as methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, naphthalenesulfonic acid and naphthalene-1,5-disulfonic acid; aliphatic monocarboxylic acids having preferably 1-18 C atoms, such as formic acid, acetic acid, propionic acid, butyric acid, lauric acid, palmitic acid and stearic acid; halogen-containing monocarboxylic acids, such as chloroacetic acid, dichloroacetic acid, trichloroacetic acid and trifluoroacetic acid; aliphatic dicarboxylic acids having preferably 2-12 C atoms, such as malonic acid, succinic acid, adipic acid and sebacic acid; substituted or unsubstituted aromatic mono- and dicarboxylic acids, such as benzoic acid, toluic acid, naphthoic acid, phthalic acid and terephthalic acid; and aliphatic and aromatic phosphonic and phosphinic acids, such as methyl-, benzyl- or phenyl-phosphonic acid or dimethyl- and diethyl-phosphonic acid or diethyl- and benzene-phosphinic acid.Hydrochloric acid is preferably used as the proton acid.Another way in which the optically active cyclobutanone of the formula II can be liberated comprises decomposing the salts of the formula III in the presence of water and an organic solvent, preferably a water-immiscible solvent, such as hydrocarbons, which can be chlorinated, or a dialkyl ether, at a pH value of above 7.0. In order to prevent the Favorski reaction, which takes place at higher pH values, the reaction is preferably carried out at pH values between 7.0 and 7.5 and at temperatures below 25.degree. C. With a particularly mild and time-saving variant of this decomposition procedure, the sulfurous acid liberated during the reaction is oxidised with the aid of a weak oxidising agent, such as an iron-III salt or iodine. The optically active base which is also liberated can be separated from the cyclobutanone by subsequent extraction with an aqueous acid and recovered.The conversion of the pure diastereomers of the formula III or of the optically active cyclobutanones of the formula II to optically active cyclopropanecarboxylic acid derivatives of the formula I is effected in the presence of a base. Suitable bases are, for example, hydroxides and alcoholates of the formula IVM.sup.n+ (O.sup.- R).sub.n (IV)in which M is an alkali metal cation or alkaline earth metal cation and n is the number 1 or 2 and R is as defined under formula I, such as sodium hydroxide, potassium hydroxide, calcium hydroxide and barium hydroxide or sodium methylate, sodium ethylate, sodium isopropylate, sodium sec.-butylate, sodium tert.-butylate and potassium methylate, potassium ethylate, potassium isopropylate, potassium sec.-butylate and potassium tert.-butylate, magnesium methylate or sodium salts and potassium salts of benzyl alcohol, of m-phenoxybenzyl alcohol, of furfuryl alcohol or of 2-thiophenemethanol.Further suitable bases are alkali metal carbonates and alkaline earth metal carbonates and alkali metal bicarbonates, such as calcium carbonate, barium carbonate, potassium carbonate and sodium carbonate, sodium bicarbonate and potassium bicarbonate. In certain circumstances, the reaction can also be accelerated by the addition of suitable halide acceptors, for example silver nitrate.The bases are employed in at least the stoichiometric amount, but preferably in excess.Depending on the nature of the base, the reaction is advantageously carried out in an aqueous, aqueous-organic or organic medium. If the base used is an alkali metal carbonate or alkaline earth metal carbonate, the reaction is carried out in an aqueous or aqueous-organic medium. The reaction in the presence of alkali metal hydroxides or alkaline earth metal hydroxides and alkali metal bicarbonates is also advantageously carried out in an aqueous or aqueous-organic medium. After acidifying the reaction mixture, for example by the addition of concentrated hydrochloric acid, compounds are obtained in which R=H and these can be converted in a known manner to derivatives of the formula I in which R.noteq.H, for example by conversion to the corresponding acid chloride and reaction with an alcohol derived from the radical R.Suitable organic solvents for the reaction in an aqueous-organic or organic medium are lower alcohols, for example those having not more than 6 C atoms, benzyl alcohol, aliphatic and cyclic ethers, such as diethyl ether, di-n-propyl ether, di-isopropyl ether, tetrahydrofuran, tetrahydropyran and dioxan, and also aliphatic, cycloaliphatic or aromatic hydrocarbons, such as n-pentane, n-hexane, cyclohexane, benzene, toluene and xylenes.In order to form a cyclopropanecarboxylic acid derivative which has a high content of cis-isomers, the Favorski reaction is advantageously carried out at -10.degree. to +10.degree. C. The reaction mixture is then heated to elevated temperature, and if necessary to the boiling point of the reaction medium, in order to effect complete conversion of the trihalogenoethyl group to a dihalogenovinyl group.When the pure diastereomers of the formula III are reacted in the presence of a base, optically active cyclobutanones of the formula II form as intermediates.According to a preferred embodiment, the pure diastereomers of the formula III are decomposed, as described, to give optically active cyclobutanones of the formula II, after which the latter are converted in the presence of a base to optically active compounds of the formula I, the products formed being in the main compounds of the formula I in the cis-configuration. If desired, the compounds of the formula I can then be converted to compounds of the formula I'.The optically active cyclobutanones of the formula II which have the undesired configuration can be converted in the presence of a catalyst to corresponding racemates which contain a high proportion of optically active cyclobutanone with the desired configuration and these racemates can, in turn, be used to obtain diastereomeric sulfonic acid salts of the formula III and thus to obtain optically active cyclobutanones of the formula II which have the desired configuration.Suitable catalysts for the racemisation of the optically active cyclobutanones of the formula II which have the undesired configuration are acids, quaternary ammonium halides or bases.Examples of acid catalysts which can be used are inorganic or organic proton acids of the abovementioned type or, alternatively, Lewis acids, such as boron trichloride, boron trifluoride, aluminium trichloride, iron trichloride or zinc chloride.Furthermore, salts of proton acids, especially hydrogen halide acids, with ammonia or a nitrogen-containing organic base can be employed.Suitable nitrogen-containing organic bases are aliphatic, cycloaliphatic, araliphatic and aromatic primary, secondary and tertiary amines and also heterocyclic nitrogen bases. Examples are: primary aliphatic amines having not more than 12 C atoms, such as methylamine, ethylamine, n-butylamine, n-octylamine, n-dodecylamine, hexamethylenediamine, cyclohexylamine and benzylamine; secondary aliphatic amines having not more than 12 C atoms, such as dimethylamine, diethylamine, di-n-propylamine, dicyclohexylamine, pyrrolidine, piperidine, piperazine and morpholine; tertiary aliphatic amines, especially trialkylamines having 1-4 C atoms in each alkyl moiety, such as triethylamine, tri-n-butylamine, N-methyl pyrrolidine, N-methylmorpholine, 1,4-diazabicyclo[2.2.2]-octane and quinuclidine; substituted or unsubstituted primary, secondary and tertiary aromatic amines, such as aniline, toluidine, naphthylamine, N-methylaniline, diphenylamine and N,N-diethylaniline; and also pyridine, picoline, indoline and quinoline.Preferred salts are those of the formula ##STR5## in which M.sub.1 is fluorine, bromine or iodine, especially chlorine, Q.sub.1, Q.sub.2 and Q.sub.3 independently of one another are hydrogen or alkyl having 1-18 C atoms and Q.sub.4 is hydrogen, alkyl having 1-18 C atoms, cyclohexyl, benzyl, phenyl or naphthyl, and also N-alkyl-pyridinium halides having 1-18 C atoms in the alkyl, especially the corresponding chlorides.Examples of such salts are: ammonium chloride, ammonium bromide, methylamine hydrochloride, cyclohexylamine hydrochloride, aniline hydrochloride, dimethylamine hydrochloride, di-isobutylamine hydrochloride, triethylamine hydrochloride, triethylamine hydrobromide, tri-n-octylamine hydrochloride, benzyl-dimethylamine hydrochloride, tetramethyl-, tetraethyl-, tetra-n-propyl- and tetra-n-butyl-ammonium chloride, bromide and iodide, trimethylhexadecylammonium chloride, benzyldimethylhexadecylammonium chloride, benzyldimethyltetradecylammonium chloride, benzyl-trimethyl-, -triethyl- and -tri-n-butyl-ammonium chloride, n-butyl-tri-n-propyl-ammonium bromide, octadecyltrimethylammonium bromide, phenyltrimethylammonium bromide or chloride and hexadecylpyridinium bromide and chloride.Suitable basic catalysts are organic bases, such as primary, secondary and especially tertiary amines of the formula ##STR6## in which Q.sub.5 is alkyl having 1-8 C atoms, cycloalkyl having 5 or 6 C atoms, benzyl or phenyl and Q.sub.6 and Q.sub.7 independently of one another are hydrogen or alkyl having 1-8 C atoms, for example triethylamine, tri-n-butylamine, triisopentylamine, tri-n-octylamine, N,N-dimethyl-cyclohexylamine, N,N-dimethyl-benzylamine, N,N-dimethyl-2-ethylhexylamine and N,N-diethylaniline; and also cyclic amines, such as pyridine, quinoline, lutidine, N-alkylmorpholines, such as N-methylmorpholine, N-alkylpiperidines, such as N-methyl- and N-ethyl-piperidine, and N-alkylpyrrolidines, such as N-methyl- and N-ethyl-pyrrolidine; diamines, such as N,N,N',N'-tetramethylethylenediamine, N,N,N',N'-tetramethyl-1,3-diamino-butane and N,N'-dialkylpiperazines, such as N,N'-dimethylpiperazine; bicyclic diamines, such as 1,4-diaza-bicyclo[2.2.2]octane, and bicyclic amidines, such as 1,5-diazabicyclo[5.4.0]undec-5-ene and 1,5-diazabicyclo[4.3.0]non-5-ene, and finally polymeric basic compounds, such as p-dimethylaminomethyl-polystyrene.If acids or bases are used in excess, they can also serve as solvents.Substances which can be used as additional co-catalysts are alkali metal halides, such as potassium iodide, sodium iodide, lithium iodide, potassium bromide, sodium bromide, lithium bromide, potassium chloride, sodium chloride, lithium chloride, potassium fluoride, sodium fluoride and lithium fluoride.The amount in which the catalyst is employed can vary within wide limits. In general, the catalyst is employed in an amount of about 5 to 100 percent by weight, based on the optically active compound of the formula II.The racemisation can be carried out either in the melt or in an inert organic solvent. The reaction temperatures for the racemisation in the melt are in general approximately between 50.degree. and 150.degree. C. and in particular between about 80.degree. and 130.degree. C.Catalysts suitable for the racemisation in the melt are, in particular, the abovementioned salts of hydrogen halide acids with ammonia or organic nitrogen-containing bases, such as trialkylamine hydrochlorides and hydrobromides, having 1-8 C atoms in each alkyl moiety, and very particularly tetraalkylammonium halides, in particular tetraalkylammonium chlorides, bromides and iodides, having 1-18 C atoms in each alkyl moiety. It is also possible to use bases of the type mentioned, especially trialkylamines having 1-8 C atoms in each alkyl moiety, such as triethylamine, tri-n-butylamine and ethyldiisopropylamine.Suitable inert organic solvents are, for example, those of the type mentioned for the preparation of the salts of the formula III, and also aliphatic monocarboxylic acids. The reaction temperatures for the racemisation in an inert organic solvent are approximately between 0.degree. and 150.degree. C. and especially between about 80.degree. and 130.degree. C. Preferred solvents are acetic acid and ethanol, and the catalysts used are advantageously hydrogen halide acids, especially hydrobromic acid or hydrochloric acid.In polar solvents, such as aliphatic alcohols or diols, cyclic amides, amides of carbonic acid, amides of phosphorous acid, of phosphoric acid, of phenylphosphonic acid or of aliphatic phosphonic acids, amides of sulfuric acid or of aliphatic or aromatic sulfonic acids, N,N-dialkylamides of aliphatic monocarboxylic acids, nitriles or dialkylsulfoxides of the abovementioned type, the racemisation proceeds on heating, even without the addition of acids, quaternary ammonium halides or bases. In these cases, the solvent acts as the catalyst.Cyclobutanones of the formula II in which R.sub.1 and R.sub.2 are as defined and X and Y independently of one another are chlorine or bromine can be prepared, starting from readily accessible starting materials, in a simple manner and in good yield by a novel synthesis which comprises reacting a compound of the formula V ##STR7## in the presence of an organic base, with an olefin of the formula VI ##STR8## to give a compound of the formula VII ##STR9## and rearranging the compound of the formula VII in the presence of a catalyst to give a cyclobutanone of the formula II in which R.sub.1, R.sub.2, Y and X are as defined (cf. German Offenlegungsschrift No. 2,813,337).Cyclobutanones of the formula II in which X, R.sub.1 and R.sub.2 are as defined under formula I or I' and Y is a group --OSO.sub.2 R' can be obtained by converting a compound of the formula VII, in the presence of an inorganic base, such as alkali metal hydroxides, carbonates or bicarbonates or alkaline earth metal hydroxides, carbonates or bicarbonates, to a 2,2,2-trichloro- or 2,2,2-tribromoethylhydroxycyclobutanone of the formula VIIIa or VIIIb ##STR10## and then reacting the compound of the formula VIIIa or VIIIb, in the presence of an organic base, such as tertiary amines, with a compound R'--SO.sub.2 --Cl. This procedure in general yields mixtures of cyclobutanones of the formula II in which Y=--OSO.sub.2 R' and isomers of the formula ##STR11## which can be separated from one another in a conventional manner.Preferred compounds of the formula I or I' are those in which R is an alkyl group having 1-4 carbon atoms and in particular hydrogen.Alkyl groups R can be straight-chain or branched. Examples of suitable alkyl groups R are: the methyl, ethyl, n-propyl, isopropyl and n-butyl group. Preferably, the said alkyl groups are straight-chain.Alkyl groups R' can likewise be straight-chain or branched and preferably have 1-4 C atoms. Halogenoalkyl groups R' are in particular chlorinated, brominated or fluorinated, branched or straight-chain alkyl groups. Examples of suitable halogenalkyl groups R' are: the chloromethyl, trifluoromethyl or perfluoro-n-butyl group.Possible substituents in a substituted phenyl group R' are, in particular, alkyl groups having 1-4 and especially 1 or 2 C atoms, halogen atoms, such as chlorine and bromine, and nitro groups. Preferably, phenyl groups R' have only one substituent of the indicated type. Examples of suitable substituted phenyl groups R' are: the 3- or 4-methylphenyl, 4-ethylphenyl, 2- and 4-nitrophenyl, 4-chlorophenyl and 4-bromophenyl group.If R' is a naphthyl group, the sulfonyl group can be in the 1-position or 2-position of the naphthalene radical.Compounds of the formula I or I' in which R=H or alkyl having 1-4 C atoms, which have been obtained according to the invention, can be converted in a manner known per se to compounds of the formula I or I' in which R is a group ##STR12## R.sub.3, R.sub.4 and R.sub.5 are as defined under formula I or I' and R.sub.6 ' is hydrogen, ethynyl or cyano, for example by reaction with corresponding halides or alcohols (the latter if desired with prior conversion of the compound of the formula I or I' to the acid chloride) or by trans-esterification.The bromination of the compounds of the formula I to give compounds of the formula I' can be carried out by methods known per se, for example by the method described in German Offenlegungsschrift No. 2,805,312, before or after any conversion of compounds of the formula I in which R=H or alkyl to compounds of the formula I in which R is a group (a) or (b).Preferred cyclobutanones of the formula II are those in which X is chlorine or bromine, one of R.sub.1 and R.sub.2 is methyl and the other is hydrogen or methyl, or R.sub.1 and R.sub.2 together are alkylene having 2-3 C atoms, especially ethylene, and Y is chlorine, bromine or a group --OSO.sub.2 R', in which R' is alkyl or halogenoalkyl having 1-4 C atoms, benzyl, phenyl, methylphenyl, nitrophenyl, chlorophenyl or bromophenyl, and in particular compounds of the formula II and III in which A has the preferred meaning defined above and X is chlorine, R.sub.1 and R.sub.2 are each methyl and Y is a group --OSO.sub.2 R', in which R' is methyl, 4-methylphenyl or 4-bromophenyl.Particularly preferred cyclobutanones of the formula II are those in which X and Y independently of one another are chlorine or bromine, one of R.sub.1 and R.sub.2 is methyl and the other is hydrogen methyl, or R.sub.1 and R.sub.2 together are alkylene having 2-3 C atoms, especially ethylene, and in particular compounds of this type in which R.sub.1 and R.sub.2 are each methyl. Very particularly preferred cyclobutanones of the formula II are those in which R.sub.1 and R.sub.2 are each methyl and X and Y are each chlorine, or X is bromine and Y is chlorine.The compounds of the formula I and I' in which R is a group ##STR13## and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 ' are as defined are suitable for the control of diverse animal or plant pests, especially insects. The properties, fields of application and use forms of these active substances are described in the literature (cf., for example, Nature, 246, 169-170 (1973); Nature, 248, 710-711 (1974); Proceedings 7th British Insecticide and Fungicide Conference, 721-728 (1973); Proceedings 8th British Insecticide and Fungicide Conference, 373-78 (1975); J. Agr. Food Chem. 23, 115 (1973); U.S. Pat. No. 3,961,070 and German Offenlegungsschriften Nos. 2,553,991, 2,439,177, 2,326,077 and 2,614,648). The process according to the invention enables optically active cyclopropanecarboxylic acid derivatives of the formula I or I' with the cis-configuration to be prepared in a simple manner. This is of particular interest, since the cyclopropanecarboxylic acid derivatives of the formula I or I', in which R is a group (b), possess a considerably more powerful insecticidal action than the corresponding compounds with the transconfiguration.A particular advantage of the process according to the invention is that the optically active cyclobutanones of the formula II which are thus obtained with the undesired configuration can be converted again, in the presence of catalysts, to the starting racemate with high proportions of the cis-configuration.

    摘要翻译： 描述了制备在3位上被取代的光学活性的2-（2'，2'-二卤代乙烯基） - 环丙烷-1-羧酸及其衍生物的新方法。 某些环丁酮的外消旋物与光学活性碱的亚硫酸盐反应，得到非对映异构体4-2-（2'，2'，2'-三卤代乙基） - 环丁烷-1-磺酸盐的混合物; 然后将该混合物分离成纯的非对映体磺酸盐。 将纯的非对映异构体磺酸盐直接转化成所需的光学活性产物，或者通过分解从纯非对映体磺酸盐获得的光学活性环丁酮在碱的存在下转化为所需产物。 任选地，产物光学活性的2-（2'，2'-二卤代乙烯基） - 环丙烷-1-羧酸可以转化为它们的1'，2'-二溴衍生物。