公开(公告)号：US5932249A

公开(公告)日：1999-08-03

申请号：US619556

申请日：1996-07-15

Applicant: Peter Gruber ,  Hans Joachim Lach ,  Norbert Otterbeck

Inventor： Peter Gruber ,  Hans Joachim Lach ,  Norbert Otterbeck

IPC: A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K31/58 ,  A61K47/32 ,  A61K9/14

CPC classification number: C12Y304/24 ,  A61K31/58 ,  A61K9/5078

Abstract: Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacquer insoluble in gastric fluids but soluble in intestinal fluids and 3 to 20% of at least one lacquer insoluble in both gastric and intestinal fluids; and d) a second lacquer coating consisting of at least one lacquer insoluble in gastric and intestinal fluids. The invention also relates to a process for producing budesonide pellets with a controlled release pattern.

Abstract translation: PCT No.PCT / EP94 / 02531 Sec。 371日期：1996年7月15日 102（e）日期1996年7月15日PCT提交1994年7月29日PCT公布。 公开号WO95 / 08323 日期1995年3月30日公开是具有控制释放模式的布地奈德颗粒，其包含从内到外的：a）中性颗粒; b）微粉化布地奈德和一种或多种水溶性助剂的活性主层; c）第一漆包衣，其由80-97％的至少一种不溶于胃液但可溶于肠液的漆和3至20％至少一种不溶于胃液和肠液的漆组成; 和d）由至少一种不溶于胃液和肠液的漆组成的第二漆层。 本发明还涉及一种具有控制释放模式的布地奈德颗粒的制备方法。

公开(公告)号：US4707309A

公开(公告)日：1987-11-17

申请号：US593978

申请日：1984-03-27

Applicant: Gunther M. Voss ,  Volker I. Glasel ,  Peter Gruber ,  Walter Bubeck

Inventor： Gunther M. Voss ,  Volker I. Glasel ,  Peter Gruber ,  Walter Bubeck

IPC: B05B1/14 ,  A23P1/02 ,  A23P1/10 ,  A61J3/10 ,  A61K9/28 ,  B05B7/04 ,  B30B11/00 ,  B30B15/00 ,  B29C33/58 ,  B29C43/58

CPC classification number: B30B15/0011 ,  Y10S425/115

Abstract: The invention is directed to a process for dotting molding tools with droplets of liquid or suspended lubricant in the production of shaped articles in the pharmaceutical, food, or catalyst fields. Pressurized lubricant solutions or suspensions and pressurized gas are alternately passed through capillaries, in conjunction with alternating single-substance nozzles, in such a way that drops are formed on the nozzle surface, in between the jets of gas, and are then detached form this surface and directed to specific zones of pressing tools. The apparatus comprises fast-acting valves for the brief release of pressurized gases and lubricant liquids or suspensions. The delivery lines of a gas valve and a liquid valve combine upstream of a capillary, and single-substance nozzles are mounted at the end of the capillaries.

Abstract translation: 本发明涉及一种用于在制药，食品或催化剂领域中成形制品的生产中点滴具有液体液滴或悬浮润滑剂的模制工具的方法。 加压的润滑剂溶液或悬浮液和加压气体与交替的单一物质喷嘴交替地通过毛细管，使得在喷嘴表面之间，在气体喷射之间形成液滴，然后从该表面上分离 并针对特定的按压工具区域。 该装置包括用于短暂释放加压气体和润滑剂液体或悬浮液的快速作用阀。 气体阀和液体阀的输送管线组合在毛细管的上游，单个物质的喷嘴安装在毛细管的末端。

公开(公告)号：US4650664A

公开(公告)日：1987-03-17

申请号：US772166

申请日：1985-09-03

Applicant: Gottfried Schepky ,  Rolf Brickl ,  Peter Gruber ,  Jochen Schmid ,  Ursula Springmeier

Inventor： Gottfried Schepky ,  Rolf Brickl ,  Peter Gruber ,  Jochen Schmid ,  Ursula Springmeier

IPC: C07D487/04 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K31/505 ,  A61K47/12 ,  A61P7/02 ,  A61K9/54

CPC classification number: A61K9/2013 ,  A61K31/505 ,  A61K9/4841 ,  A61K9/5078

Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol or its acid addition salt.

Abstract translation: 本发明涉及给予莫匹达莫的载体。 更具体地说，本发明涉及在需要这种治疗的宿主中治疗心血管疾病，恶性肿瘤或血栓形成的方法，该方法包括向所述宿主施用心血管，抗重复或抗血栓形成的有效量的组合物，所述组合物包含（i）莫比达莫 或其酸加成盐和（ii）至少一种药理学上可接受的酸或酸物质，存在酸加成盐的酸的总量和酸或酸性物质的比例为至少约1当量酸1摩尔 莫比达莫或其酸加成盐。

公开(公告)号：US4548825A

公开(公告)日：1985-10-22

申请号：US538200

申请日：1983-10-03

Applicant: Gunther Voss ,  Peter Gruber

Inventor： Gunther Voss ,  Peter Gruber

IPC: A61J3/00 ,  A61K9/20 ,  B41J3/407 ,  A61K9/00 ,  A23L1/00

CPC classification number: A61K9/2095 ,  A61J3/00 ,  B41J3/4073 ,  A61J2205/20

Abstract: This invention is directed to a method for the non-contact application of letters or symbols to the exterior surfaces of uncoated tablets or uncoated tablet cores, which comprises dotting color solution or suspension by means of an ink-jet printer in specific quantity in the form of discrete droplets of specific volume onto the exterior surfaces of the uncoated tablets or uncoated tablet cores.

Abstract translation: 本发明涉及一种用于在未涂覆片剂或未包衣片芯的外表面上非接触施加字母或符号的方法，其包括通过喷墨打印机以特定数量的形式点滴颜色溶液或悬浮液 具有特定体积的离散液滴到未包衣片剂或未包衣片芯的外表面上。

公开(公告)号：US4524281A

公开(公告)日：1985-06-18

申请号：US439060

申请日：1982-11-03

Applicant: Jurg Muggli ,  Peter Gruber

Inventor： Jurg Muggli ,  Peter Gruber

IPC: G01N21/53 ,  G08B17/10 ,  G08B17/107

CPC classification number: G08B17/107 ,  G08B17/113

Abstract: A smoke detector is disclosed containing a radiation source and a radiation receiver arranged externally of a direct radiation region of the radiation source. In the presence of smoke or other combustion particles in the radiation region the radiation receiver is impinged by scattered radiation. The smoke detector contains optical elements which can be altered by external mechanical actuation, by means of which it is possible to alter in a predetermined manner an output signal of the radiation receiver. In this regard it is possible to either mechanically alter the solid angle which is so-to-speak viewed by the radiation receiver or the solid angle irradiated by the radiation source. The constriction of the active solid angle is preferably accomplished by a diaphragm or membrane displaceable along the radiation direction. Displacement of the diagram is preferably achieved in that, this diaphragm engages by means of dogs or detents in a cam groove, such as a helical-shaped groove of a cam disk, and by rotating the cam disk there can be achieved a defined displacement of the diaphragm.

Abstract translation: 公开了一种烟雾探测器，其包含布置在辐射源的直接辐射区域的外部的辐射源和辐射接收器。 在辐射区域内存在烟雾或其他燃烧颗粒的情况下，辐射接收器被散射辐射撞击。 烟雾探测器包含可以通过外部机械致动而改变的光学元件，借助于此，可以以预定方式改变辐射接收器的输出信号。 在这方面，可以机械地改变辐射接收器所观察到的立体角或由辐射源照射的立体角。 活性立体角的收缩优选通过沿辐射方向可移位的隔膜或膜来实现。 优选地实现该图的位移，其中该隔膜通过诸如凸轮盘的螺旋形凹槽的凸轮槽中的卡爪或棘爪啮合，并且通过旋转凸轮盘可以实现定义的位移 隔膜。

公开(公告)号：US4367217A

公开(公告)日：1983-01-04

申请号：US221834

申请日：1980-12-31

Applicant: Peter Gruber ,  Rolf Brickl ,  Gerhard Bozler ,  Herbert Stricker

Inventor： Peter Gruber ,  Rolf Brickl ,  Gerhard Bozler ,  Herbert Stricker

IPC: A61K9/16 ,  A61K9/22 ,  A61K9/24 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K9/56 ,  A61K31/505 ,  A61P9/08 ,  A61P9/10 ,  A61K9/26

CPC classification number: A61K9/5042 ,  A61K31/505 ,  A61K9/1617 ,  A61K9/5026 ,  A61K9/5078

Abstract: This invention relates to a composition for the sustained release of dipyridamole which comprises (i) spheroid particles comprised of dipyridamole or crystallized salts thereof and pharmacologically acceptable acid or acid substance, and (ii) a coating surrounding said spheroid particles, said coating being comprised of from about 50 to 100 percent by weight of acid-insoluble lacquers soluble in intestinal juices and from about 0 to 50 percent by weight of lacquers insoluble in gastric and intestinal juices and said coating being present in an amount of from about 3 to 30 percent by weight, based on the weight of the spheroid particles, and to the preparation of such a composition.

Abstract translation: 本发明涉及用于缓释双嘧达莫的组合物，其包括（i）由双嘧达莫或其结晶盐和药理学上可接受的酸或酸性物质组成的球状颗粒，和（ii）围绕所述球状颗粒的涂层，所述涂层由 约50至100重量％的可溶于肠液的酸不溶性漆和约0至50重量％不溶于胃肠和肠液的漆，并且所述涂层以约3至30重量％的量存在， 重量，基于球状颗粒的重量，以及这种组合物的制备。

公开(公告)号：US4339589A

公开(公告)日：1982-07-13

申请号：US175593

申请日：1980-08-05

Applicant: Wolfgang Steglich ,  Rudolf Hurnaus ,  Peter Gruber ,  Boerries Kuebel

Inventor： Wolfgang Steglich ,  Rudolf Hurnaus ,  Peter Gruber ,  Boerries Kuebel

IPC: C07D263/42 ,  C07D265/10

CPC classification number: C07D263/42

Abstract: Manufacture of 4-substituted oxazolinone-(5) compounds, which are intermediates for substituted aminoacids, by alkylation of 2-substituted or 3,4-disubstituted oxazolinone-(5) compounds in an aprotic solvent in the presence of a tertiary amine.

Abstract translation: 通过在非质子溶剂中在叔胺存在下，通过2-取代或3,4-二取代的恶唑啉酮 - （5）化合物的烷基化制备4-取代的恶唑啉酮 - （5）化合物，它们是取代的氨基酸的中间体。

公开(公告)号：USD693710S1

公开(公告)日：2013-11-19

申请号：US29441551

申请日：2013-01-07

Applicant: Thomas Bachel ,  Matthias Droll ,  Peter Gruber

Designer： Thomas Bachel ,  Matthias Droll ,  Peter Gruber

公开(公告)号：US20100035937A1

公开(公告)日：2010-02-11

申请号：US12443446

申请日：2007-08-30

Applicant: Peter Gruber ,  Peter Kraahs

Inventor： Peter Gruber ,  Peter Kraahs

IPC: A61K31/192 ,  A61K31/196 ,  A61K31/44 ,  A61K31/405 ,  A61K31/381 ,  A61P29/00

CPC classification number: A61K9/143 ,  A61K9/1611 ,  A61K31/192

Abstract: A process for producing a solubilized non-steroidal anti-inflammatory drug (NSAID) the process comprising the steps of: providing a mixture comprising solid NSAID and a first base which is selected from the group of bases which have a pH of at least 11 as 0.1 molar aqueous solution or dispersion, and reacting the NSAID and the first base in essentially dry state, solubilized NSAID obtainable by this process and pharmaceutical compositions comprising the same.

Abstract translation: 一种生产溶解的非甾体抗炎药（NSAID）的方法，该方法包括以下步骤：提供包含固体NSAID和选自pH至少为11的碱基的第一碱的混合物 0.1摩尔水溶液或分散体，并使NSAID和第一碱基基本上干燥状态，通过该方法获得的可溶性NSAID和包含该NSAID的药物组合物。

公开(公告)号：US20090270515A1

公开(公告)日：2009-10-29

申请号：US12441629

申请日：2007-09-14

Applicant: Peter Gruber ,  Dirk Spickermann

Inventor： Peter Gruber ,  Dirk Spickermann

IPC: A61K47/12 ,  A61K47/02 ,  A61K47/26 ,  A61P43/00

CPC classification number: A61K9/2009 ,  A61K9/1611

Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.

Abstract translation: 本发明涉及含有至少一种活性成分和至少一种药学上相容的水溶性干燥剂的固体药物形式，其选自氯化三钙和/或氯化钙，固体药物形式具有干燥损失 最多6％，相对平衡含水量25％以下。 本发明还涉及含有湿敏性活性成分和十六酸镁的固体药物形式。