公开(公告)号：US20120275563A1

公开(公告)日：2012-11-01

申请号：US13098173

申请日：2011-04-29

申请人： Joseph John Manak ,  Bernhard Erich Hermann Claus ,  Jens Rittscher ,  Hao Lai ,  Jeffrey Wayne Eberhard ,  Kedar Bhalchandra Khare ,  Cyril Riddell ,  Yves Lucien Trousset

发明人： Joseph John Manak ,  Bernhard Erich Hermann Claus ,  Jens Rittscher ,  Hao Lai ,  Jeffrey Wayne Eberhard ,  Kedar Bhalchandra Khare ,  Cyril Riddell ,  Yves Lucien Trousset

IPC分类号： G01N23/04

CPC分类号： A61B6/4452 ,  A61B6/00 ,  A61B6/027

摘要： The subject matter disclosed herein relates to X-ray imaging systems, and more specifically to digital X-ray imaging systems. In one embodiment, an imaging system includes an X-ray source configured to emit X-rays. The imaging system also includes an X-ray detector configured to detect the emitted X-rays and produce a corresponding electrical signal. The imaging system also includes a gantry configured to at least partially revolve the X-ray source and the X-ray detector about a primary rotational axis. The X-ray detector is coupled to the gantry so that a diagonal of the X-ray detector is oriented substantially perpendicular to the primary rotational axis.

摘要翻译： 本文公开的主题涉及X射线成像系统，更具体地涉及数字X射线成像系统。 在一个实施例中，成像系统包括被配置为发射X射线的X射线源。 成像系统还包括被配置为检测所发射的X射线并产生相应的电信号的X射线检测器。 成像系统还包括构造成使X射线源和X射线检测器围绕主旋转轴线至少部分地旋转的台架。 X射线检测器耦合到台架，使得X射线检测器的对角线基本上垂直于主旋转轴线定向。

公开(公告)号：US07940978B2

公开(公告)日：2011-05-10

申请号：US11758531

申请日：2007-06-05

申请人： Jens Rittscher ,  Thomas B. Sebastian ,  Stewart E. Abbot

发明人： Jens Rittscher ,  Thomas B. Sebastian ,  Stewart E. Abbot

IPC分类号： G06K9/00 ,  G01N33/48

CPC分类号： G06T7/20 ,  A61B5/1105 ,  A61B2503/40 ,  A61B2503/42 ,  G06K9/0014 ,  G06T2207/30024

摘要： The present techniques provide for the evaluation of cellular motion and/or cellular properties based on an analysis of motion. In an exemplary technique, images of one or more cells are acquired and motion data for the one or more cells is derived from the images. The motion data is decomposed to generate one or more motion components. The one or more motion components can be used to evaluate cellular properties and/or cellular motion properties.

摘要翻译： 本技术基于运动分析提供了细胞运动和/或细胞特性的评估。 在示例性技术中，获取一个或多个单元的图像，并且从该图像导出一个或多个单元的运动数据。 运动数据被分解以产生一个或多个运动分量。 一个或多个运动分量可用于评估细胞特性和/或细胞运动特性。

公开(公告)号：US20110069905A1

公开(公告)日：2011-03-24

申请号：US12993180

申请日：2009-05-29

申请人： Umesha Adiga ,  Ali Can ,  Xudong Li ,  Dirk r. Padfield ,  Jens Rittscher ,  Elizabeth P. Roquemore

发明人： Umesha Adiga ,  Ali Can ,  Xudong Li ,  Dirk r. Padfield ,  Jens Rittscher ,  Elizabeth P. Roquemore

IPC分类号： G06K9/36

CPC分类号： G06T7/0012 ,  G01N15/1475 ,  G06T7/42 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/20064 ,  G06T2207/30024 ,  G06T2207/30168

摘要： This invention, which provides a method for detecting a corruption in an image acquired from a biological sample, includes: providing at least one image of at least one cell; generating the image of the at least one cell over a period of time; determining if the at least one image of the at least one cell is corrupted; applying a wavelet transform, Fourier transform, or other frequency decomposing transform to the at least one image to decompose the at least one image into a plurality of sub-images, wherein the plurality of sub-images have a plurality of low frequency channels, a plurality of middle frequency channels and a plurality of high frequency channels; calculating a ratio based on an energy level of the plurality of low frequency channels and the plurality of middle frequency channels; and removing the at least one image of at least one cell if the at least one image is corrupted.

摘要翻译： 本发明提供一种用于检测从生物样品获得的图像中的破坏的方法，包括：提供至少一个单元的至少一个图像; 在一段时间内产生所述至少一个小区的图像; 确定所述至少一个小区的所述至少一个图像是否被破坏; 对所述至少一个图像应用小波变换，傅里叶变换或其他频率分解变换，以将所述至少一个图像分解为多个子图像，其中所述多个子图像具有多个低频信道， 多个中频信道和多个高频信道; 基于所述多个低频信道和所述多个中频信道的能级计算比率; 以及如果所述至少一个图像被破坏，则移除所述至少一个单元的所述至少一个图像。

公开(公告)号：US20110026803A1

公开(公告)日：2011-02-03

申请号：US12533406

申请日：2009-07-31

申请人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

发明人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

IPC分类号： G06K9/00

CPC分类号： G06T5/004 ,  G06T2207/10024 ,  G06T2207/30024

摘要： Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image.

摘要翻译： 用于数字增强先前施加多个污渍的材料的初始图像的方法和系统，其通常包括：将图像混合成多个单独的重建图像，每个单独图像对应于一个污渍; 估计对应于原始图像和重建图像之间的差的残差图像; 调整各个图像的一个或多个分量; 使用一个或多个估计的混合系数混合调整的组分; 并且将残差图像添加到混合调整的分量以产生增强图像。

公开(公告)号：US20100119127A1

公开(公告)日：2010-05-13

申请号：US12267019

申请日：2008-11-07

申请人： Musodiq O. Bello ,  Jens Rittscher ,  Ahmad Yekta ,  Dirk Ryan Padfield ,  Jilin Tu

发明人： Musodiq O. Bello ,  Jens Rittscher ,  Ahmad Yekta ,  Dirk Ryan Padfield ,  Jilin Tu

IPC分类号： G06F9/00

CPC分类号： A01K29/00 ,  G06F19/28 ,  G06K9/00

摘要： Systems and methods for extracting information about an organism of interest, generally comprising, an atlas of the organism of interest; a storage device for at least temporarily storing an image of the organism of interest; and an operating device that automatically creates a map of the image of the organism of interest and automatically compares the map of the image to the atlas of the organism.

摘要翻译： 用于提取关于感兴趣的生物体的信息的系统和方法，通常包括感兴趣的生物体的图谱; 用于至少临时存储感兴趣的生物体的图像的存储装置; 以及自动创建感兴趣生物体的图像的图的操作装置，并自动将图像的图与生物体的图谱进行比较。

公开(公告)号：US20100104513A1

公开(公告)日：2010-04-29

申请号：US12259944

申请日：2008-10-28

申请人： Jens Rittscher ,  Umesha Perdoor Srinivas Adiga ,  Kenneth Michael Fish ,  Anup Sood ,  Kathleen Bove ,  Evelina Roxana Loghin

发明人： Jens Rittscher ,  Umesha Perdoor Srinivas Adiga ,  Kenneth Michael Fish ,  Anup Sood ,  Kathleen Bove ,  Evelina Roxana Loghin

IPC分类号： A61K49/00 ,  G06K9/00

CPC分类号： G06T7/0012 ,  G06K2209/053 ,  G06T7/12 ,  G06T7/136 ,  G06T2207/10048 ,  G06T2207/20116 ,  G06T2207/30096

摘要： The present disclosure generally relates to systems and methods for identifying the boundaries of tumors and assessing quantitatively the ability of dyes to highlight a tumor's boundary. In accordance with these methods and systems, images are taken of subjects administered agents labeled with dyes. After accessing the images, tumors are selected and routines employed to both identify the boundaries of the tumors, as well as, to quantify various aspects of the tumor boundaries. From these quantifiable descriptors the performances of the various dyes to highlight the boundaries of tumors are evaluated.

摘要翻译： 本公开一般涉及用于鉴定肿瘤边界的系统和方法，并定量评估染料突出肿瘤边界的能力。 根据这些方法和系统，拍摄被染色剂标记的药剂的受试者的图像。 在访问图像之后，选择肿瘤并且使用常规来识别肿瘤的边界，以及量化肿瘤边界的各个方面。 从这些可量化描述符中，评估各种染料突出肿瘤边界的性能。

公开(公告)号：US20090238457A1

公开(公告)日：2009-09-24

申请号：US12053295

申请日：2008-03-21

申请人： Jens Rittscher ,  Rahul Bhotika ,  Kishore Mosaliganti ,  Dirk Ryan Padfield ,  Raghu Machiraju

发明人： Jens Rittscher ,  Rahul Bhotika ,  Kishore Mosaliganti ,  Dirk Ryan Padfield ,  Raghu Machiraju

IPC分类号： G06K9/34

CPC分类号： G06K9/0014 ,  G06T7/11 ,  G06T7/143 ,  G06T2200/04 ,  G06T2207/10056 ,  G06T2207/30024

摘要： Systems and methods for segmenting images comprising cells, wherein the images comprise a plurality of pixels; one or more three dimensional (3D) clusters of cells are identified in the images; and the 3D clusters of cells are automatically segmented into individual cells using one or more models.

摘要翻译： 用于分割包括单元的图像的系统和方法，其中所述图像包括多个像素; 在图像中识别出一个或多个三维（3D）细胞簇; 并且使用一个或多个模型将单元格的3D聚类自动分割成单个单元。

公开(公告)号：US20050254546A1

公开(公告)日：2005-11-17

申请号：US10942056

申请日：2004-09-16

申请人： Jens Rittscher ,  Timothy Kelliher ,  Peter Tu

发明人： Jens Rittscher ,  Timothy Kelliher ,  Peter Tu

IPC分类号： G06K9/34 ,  G06K9/62 ,  G06T5/00 ,  G06F7/00

CPC分类号： G06K9/00778 ,  G06K9/342 ,  G06K9/6224 ,  G06T7/162 ,  G06T7/194 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/20164 ,  G06T2207/30196

摘要： A crowd segmentation system and method is described. The system includes a digital video capturing subsystem and a computing subsystem. The computing subsystem utilizes an emergent labeling technique to segment a crowd into individuals. The emergent labeling technique employs algorithms which can be used iteratively to place vertices associated with feature points in a captured digital video image into multiple cliques and, ultimately, in a single clique.

摘要翻译： 描述了人群分割系统和方法。 该系统包括数字视频采集子系统和计算子系统。 计算子系统利用紧急标签技术将人群分成个人。 紧急标签技术采用可以迭代地使用将捕获的数字视频图像中的特征点相关联的顶点放置成多个集合并且最终在单个集团中的算法。

公开(公告)号：US08948488B2

公开(公告)日：2015-02-03

申请号：US12533406

申请日：2009-07-31

申请人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

发明人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

IPC分类号： G06K9/00 ,  G06T5/00

CPC分类号： G06T5/004 ,  G06T2207/10024 ,  G06T2207/30024

摘要： Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image.

摘要翻译： 用于数字增强先前施加多个污渍的材料的初始图像的方法和系统，其通常包括：将图像混合成多个单独的重建图像，每个单独的图像对应于一个污渍; 估计对应于原始图像和重建图像之间的差的残差图像; 调整各个图像的一个或多个分量; 使用一个或多个估计的混合系数混合调整的组分; 并将残差图像添加到混合调整的分量以产生增强图像。

公开(公告)号：US20130287283A1

公开(公告)日：2013-10-31

申请号：US13460081

申请日：2012-04-30

申请人： Vidya Pundalik Kamath ,  Alberto Santamaria-Pang ,  Brion Daryl Sarachan ,  Jens Rittscher

发明人： Vidya Pundalik Kamath ,  Alberto Santamaria-Pang ,  Brion Daryl Sarachan ,  Jens Rittscher

IPC分类号： G06K9/00 ,  G09G5/02

CPC分类号： G09G5/026 ,  G01N15/1475 ,  G06K9/0014 ,  G06K9/6253 ,  G06K9/6263 ,  G09G2340/12 ,  G09G2370/022 ,  G09G2380/08

摘要： Exemplary embodiments include methods, systems, and devices for enabling users to provide quality scores for indicating the quality of image analysis methods performed on images of biological tissue. An exemplary user interface displays results of an image analysis method performed on an image of biological tissue in an overlaid manner on an image of biological tissue. The exemplary user interface enable a user to provide, directly on the user interface, one or more quality scores to indicate the user's assessment of the quality of the image analysis performed on the image. Exemplary embodiments store the quality scores provided by the user in association with the image analysis method and the image of biological tissue.

摘要翻译： 示例性实施例包括用于使用户能够提供用于指示对生物组织的图像执行的图像分析方法的质量的质量分数的方法，系统和装置。 示例性用户界面以生物组织的图像的重叠方式显示对生物组织的图像执行的图像分析方法的结果。 示例性用户界面使得用户能够直接在用户界面上提供一个或多个质量得分以指示用户对图像上执行的图像分析的质量的评估。 示例性实施例与图像分析方法和生物组织的图像相关联地存储由用户提供的质量得分。