公开(公告)号：US08906913B2

公开(公告)日：2014-12-09

申请号：US13380744

申请日：2010-06-22

申请人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Gurmeet Kaur ,  Sandeep Kanwar ,  Nishan Singh ,  Gurmeet Kaur Nanda ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

发明人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Gurmeet Kaur ,  Sandeep Kanwar ,  Nishan Singh ,  Gurmeet Kaur Nanda ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

IPC分类号： A61K31/5355 ,  C07D413/10 ,  C07D209/52 ,  C07D417/14 ,  C07D491/08 ,  C07D221/22 ,  C07D487/04 ,  C07D413/14 ,  C07D409/04 ,  C07D471/04 ,  C07D417/10 ,  C07D401/10

CPC分类号： C07D221/22 ,  C07D209/52 ,  C07D401/10 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08

摘要： The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.

摘要翻译： 本发明涉及式I的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。

公开(公告)号：US08841306B2

公开(公告)日：2014-09-23

申请号：US13130440

申请日：2009-11-18

申请人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Sandeep Kanwar ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

发明人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Sandeep Kanwar ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

IPC分类号： A61K31/33 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D413/12 ,  C07D263/20

CPC分类号： C07D487/04 ,  C07D263/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.

摘要翻译： 本发明涉及式I的新型苯基恶唑烷酮化合物，其药学上可接受的类似物，互变异构形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成新型式I化合物或其药学上可接受的类似物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。 本发明还提供了包含新颖的式I化合物和使用它们的方法的药物组合物。 本发明的化合物可用作抗微生物剂，对许多需氧和/或厌氧革兰氏阳性和/或革兰氏阴性病原体有效，如葡萄球菌，链球菌，肠球菌，细菌，梭菌，流感嗜血杆菌 ，莫拉氏菌，耐酸菌，如结核分枝杆菌，以及耐盐霉菌属的霉菌和肠球菌。

公开(公告)号：US08219230B2

公开(公告)日：2012-07-10

申请号：US12797002

申请日：2010-06-09

申请人： Bhaskar Sinha ,  Ashish Patil ,  Ajay Deshpande ,  Alpana Sharma ,  Christine Zuzart ,  Sameer Kondejkar ,  Rajesh Jain ,  Nitin Umap ,  Rahul Rajadhyaksha

发明人： Bhaskar Sinha ,  Ashish Patil ,  Ajay Deshpande ,  Alpana Sharma ,  Christine Zuzart ,  Sameer Kondejkar ,  Rajesh Jain ,  Nitin Umap ,  Rahul Rajadhyaksha

IPC分类号： G06F19/00 ,  B29C45/00

CPC分类号： B29C45/7693 ,  G06F17/50 ,  G06F2217/41

摘要： A method of automatic manufacturability evaluation of plastic models comprises generation of a likely pulling direction, recognition of common features on plastic parts, and then applying manufacturability rules The manufacturability rules can be specified and customized through user specified rule parameters and depend upon the geometric parameters of the recognized features. A system comprises a user interface for selection and customization of DFX (Design for ‘X’) rules for evaluation of a design. The system includes a user interface integrated with a CAD system for receiving the CAD data and displaying the results to the user. Geometry analysis engines are integrated into the system, for extracting the various features and corresponding parameters required as input to the manufacturability rules. The system further involves extensible interfaces for rules and analysis engines which allows users to write their own customized rules and engines and integrate these into the CAD based DFX evaluation system.

摘要翻译： 塑料模型的自动制造性评估方法包括产生可能的拉动方向，识别塑料部件上的共同特征，然后应用可制造性规则可制造性规则可以通过用户指定的规则参数来指定和定制，并且取决于几何参数 公认的功能。 系统包括用于选择和定制DFX（用于'X'的设计）用于评估设计的规则的用户界面。 该系统包括与CAD系统集成的用于接收CAD数据并将结果显示给用户的用户界面。 几何分析引擎集成到系统中，用于提取作为可制造性规则输入所需的各种功能和相应参数。 该系统还涉及规则和分析引擎的可扩展接口，允许用户编写自己的定制规则和引擎，并将其集成到基于CAD的DFX评估系统中。

公开(公告)号：US07956067B2

公开(公告)日：2011-06-07

申请号：US12299317

申请日：2007-05-09

申请人： Rajesh Jain ,  Kour Chand Jindal

发明人： Rajesh Jain ,  Kour Chand Jindal

IPC分类号： A61K31/44 ,  A61K31/40 ,  A61K36/00 ,  A61K36/82

CPC分类号： A61K36/48 ,  A61K31/045 ,  A61K36/82 ,  A61K2300/00

摘要： Novel compositions comprising a combination of at least one higher primary aliphatic alcohol preferably selected from those having 18 to 40 carbon atoms or mixtures thereof, at least one source of 5-hydroxytryptophan (5-HTP) optionally additionally comprising a source of caffeine and/or catechin-polyphenol and/or epigallocatechin gallate as active agents, either alone or in combination with other active agent(s), optionally with one or more excipient(s) are provided. Particularly, the invention relates to compositions and process for preparation of such compositions and method of use thereof for the management of obesity and associated disorders.

摘要翻译： 包含至少一种优选选自具有18-40个碳原子的高级伯脂肪醇或其混合物的至少一种5-羟基色氨酸（5-HTP）的组合的新型组合物任选地另外包含咖啡因和/或 儿茶素多酚和/或表没食子儿茶素没食子酸酯作为活性剂，单独或与其它活性剂，任选地与一种或多种赋形剂组合使用。 特别地，本发明涉及用于制备这种组合物的组合物和方法及其用于治疗肥胖症和相关疾病的方法。

公开(公告)号：US20110130434A1

公开(公告)日：2011-06-02

申请号：US13055778

申请日：2009-07-28

申请人： Rajesh Jain ,  Sarabjit Singh

发明人： Rajesh Jain ,  Sarabjit Singh

IPC分类号： A61K31/403 ,  A61P9/12

CPC分类号： A61K9/4808 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2846 ,  A61K31/403

摘要： The invention relates to a modified release pharmaceutical composition comprising ramipril or pharmaceutically acceptable salts thereof and pharmaceutically acceptable excipient(s) wherein pharmaceutical composition is bioequivalent to conventional immediate release formulation of ramipril administered twice daily. The invention further relates to a modified release pharmaceutical composition comprising: an immediate release component comprising ramipril or pharmaceutically acceptable salts thereof and a modified release component comprising ramipril or pharmaceutically acceptable salts thereof. The invention further relates to the process for the preparation of modified release pharmaceutical composition of ramipril.

摘要翻译： 本发明涉及包含雷米普立或其药学上可接受的盐和药学上可接受的赋形剂的改性释放药物组合物，其中药物组合物与常规立即释放的雷米普利制剂每天两次生物等效。 本发明还涉及一种调释释放药物组合物，其包含：包含雷米普立或其药学上可接受的盐的速释组分和包含雷米普利或其药学上可接受的盐的缓释组分。 本发明还涉及制备雷米普里缓释药物组合物的方法。

公开(公告)号：US20110093106A1

公开(公告)日：2011-04-21

申请号：US12797002

申请日：2010-06-09

申请人： Bhaskar Sinha ,  Ashish Patil ,  Ajay A. Deshpande ,  Alpana Sharma ,  Christine Zuzart ,  Sameer Kondejkar ,  Rajesh Jain ,  Nitin Umap ,  Rahul Rajadhyaksha

发明人： Bhaskar Sinha ,  Ashish Patil ,  Ajay A. Deshpande ,  Alpana Sharma ,  Christine Zuzart ,  Sameer Kondejkar ,  Rajesh Jain ,  Nitin Umap ,  Rahul Rajadhyaksha

IPC分类号： G06F19/00

CPC分类号： B29C45/7693 ,  G06F17/50 ,  G06F2217/41

摘要： A method of automatic manufacturability evaluation of plastic models comprises generation of a likely pulling direction, recognition of common features on plastic parts, and then applying manufacturability rules The manufacturability rules can be specified and customized through user specified rule parameters and depend upon the geometric parameters of the recognized features. A system comprises a user interface for selection and customization of DFX (Design for ‘X’) rules for evaluation of a design. The system includes a user interface integrated with a CAD system for receiving the CAD data and displaying the results to the user. Geometry analysis engines are integrated into the system, for extracting the various features and corresponding parameters required as input to the manufacturability rules. The system further involves extensible interfaces for rules and analysis engines which allows users to write their own customized rules and engines and integrate these into the CAD based DFX evaluation system.

摘要翻译： 塑料模型的自动制造性评估方法包括产生可能的拉动方向，识别塑料部件上的共同特征，然后应用可制造性规则可制造性规则可以通过用户指定的规则参数来指定和定制，并且取决于几何参数 公认的功能。 系统包括用于选择和定制DFX（用于'X'的设计）用于评估设计的规则的用户界面。 该系统包括与CAD系统集成的用于接收CAD数据并将结果显示给用户的用户界面。 几何分析引擎集成到系统中，用于提取作为可制造性规则输入所需的各种功能和相应参数。 该系统还涉及规则和分析引擎的可扩展接口，允许用户编写自己的定制规则和引擎，并将其集成到基于CAD的DFX评估系统中。

公开(公告)号：US20080193478A1

公开(公告)日：2008-08-14

申请号：US11661523

申请日：2004-08-27

申请人： Rajesh Jain ,  Anil Chawla ,  Ganesh Kumraj

发明人： Rajesh Jain ,  Anil Chawla ,  Ganesh Kumraj

IPC分类号： A61K39/13 ,  A61K39/295 ,  A61P31/12

CPC分类号： A61K39/13 ,  A61K39/12 ,  A61K2039/5252 ,  C12N2770/32634 ,  Y02A50/466 ,  Y02A50/484

摘要： An inactivated Polio Vaccine derived from Sabin strain for safe and effective immunization against Poliomyelitis is provided. A process of preparation for such vaccine and formulations thereof are also provided. Administration of the vaccine of the present invention along with other antigens provides immunization not only against polio infection but also against other pathogens causing Hepatitis C. Hepatitis D. Hepatitis E. Meningitis A. Meningitis B. Meningitis C. Meningitis W. Meningitis Y. Pnemococcal (23 valent or more). Smallpox, Typhoid, Bacille Calmette Guerin, Tuberculosis. Human Immunodeficiency Virus. Anthrax or the like, to which children or adults not immunized earlier are susceptible, particularly to which children are susceptible.

摘要翻译： 提供了一种来自Sabin菌株的灭活脊髓灰质炎疫苗，用于安全有效地免疫脊髓灰质炎。 还提供了这种疫苗及其制剂的制备方法。 本发明的疫苗与其他抗原一起施用不仅可以免疫脊髓灰质炎感染，而且还可以对其他引起丙型肝炎的病原体进行免疫。乙型肝炎E.脑膜炎A.脑膜炎B.脑膜炎C.脑膜炎W.脑膜炎Y. Pnemococcal （23价以上）。 天花，伤寒，卡介苗，结核病。 人类免疫缺陷病毒。 炭疽病等，以前未经过免疫接种的儿童或成人易感，特别是哪些儿童易感。

公开(公告)号：US20060261043A1

公开(公告)日：2006-11-23

申请号：US11363787

申请日：2006-02-27

申请人： Martin Betz ,  Lokesh Johri ,  Rajesh Jain ,  Theodore Lundquist ,  Tamal Basu ,  Saurabh Gupta ,  Jagadish Narayana Gade

发明人： Martin Betz ,  Lokesh Johri ,  Rajesh Jain ,  Theodore Lundquist ,  Tamal Basu ,  Saurabh Gupta ,  Jagadish Narayana Gade

IPC分类号： H01H33/14

CPC分类号： G06F17/5068

摘要： A method and apparatus for defining a circuit operation, such as a charged particle beam operation to perform a circuit edit and define a probe point. Circuit operation definition is performed in a front-end environment with access to integrated circuit computer aided design tools providing logic level and layout level information concerning the integrated circuit. The front-end environment incorporates circuit operation optimization methods to identify optimal locations for a circuit operation. A back-end environment, such as a charged particle tool computing platform, is adapted to receive one or more files, which may include a truncated layout file with circuit operation location information, for use in further defining a circuit operation and/or performing the circuit operation.

公开(公告)号：US06576625B2

公开(公告)日：2003-06-10

申请号：US09809516

申请日：2001-03-16

申请人： Amarjit Singh ,  Rajesh Jain

发明人： Amarjit Singh ,  Rajesh Jain

IPC分类号： A61K31685

CPC分类号： A61K9/1271

摘要： A composition for targeted vesicular for treatment of H-Pylori infections and for protection of the cell. The composition contains lectins, phospholipids, sterols, and one or more drugs. The composition is useful for treating H-Pylori infections and other diseases associated therewith and also helps in protecting cell walls.

公开(公告)号：US06306838B1

公开(公告)日：2001-10-23

申请号：US09490127

申请日：2000-01-24

申请人： Amarjit Singh ,  Rajesh Jain

发明人： Amarjit Singh ,  Rajesh Jain

IPC分类号： A61K31685

CPC分类号： A61K9/1271

摘要： A Novel Composition for targeted vesicular for treatment of H-Pylori infections and for protection of the cell is disclosed. The Composition Comprises Lectins, Phospholipids sterols an one or more drugs. The Composition is useful since not only it treats H-Pylori infections and other diseases associated therewith but also helps in protection of the cell walls.

摘要翻译： 公开了用于治疗幽门螺杆菌感染和保护细胞的靶向囊泡的新型组合物。 组合物包含凝胶素，磷脂甾醇一种或多种药物。 该组合物是有用的，因为它不仅治疗H-Pylori感染和与其相关的其它疾病，而且还有助于保护细胞壁。