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77 条记录 (耗时 0.031 秒)

    Function Inhibitor of Effector Cell
    45.
    发明申请
    Function Inhibitor of Effector Cell 审中-公开
    效应池功能抑制剂

    公开(公告)号：US20070270429A1

    公开(公告)日：2007-11-22

    申请号：US10555611

    申请日：2004-04-28

    申请人： Shiro Shibayama ,  Tetsuya Sugiyama ,  Kenji Sagawa ,  Miki Kasano

    发明人： Shiro Shibayama ,  Tetsuya Sugiyama ,  Kenji Sagawa ,  Miki Kasano

    IPC分类号： A61K31/498

    CPC分类号： C07D471/10 ,  A61K31/499 ,  A61K45/06

    摘要： The present invention relates to a function inhibitor of an effector cell comprising a CCR5 antagonist. Since the function inhibitor of an effector cell comprising a CCR5 antagonist inhibits the function of effector cells which play an important role in formation of diseases and the like, it is effective for the prevention and/or treatment of, for example, a transplant rejection (e.g., rejection of a solid organ graft, rejection of islet cell transplantation in diabetes mellitus, graft-versus-host disease (GVHD), etc.), an autoimmune disease (e.g., arthritis, rheumatoid arthritis, multiple sclerosis, ulcerative colitis, etc.), an allergic disease (e.g., asthma, etc.), an ischemic disease (e.g., ischemia-reperfusion injury, etc.), cancer or a metastatic disease or the like.

    摘要翻译： 本发明涉及包含CCR5拮抗剂的效应细胞的功能抑制剂。 由于包含CCR5拮抗剂的效应细胞的功能抑制剂抑制在疾病形成等中起重要作用的效应细胞的功能，所以有效预防和/或治疗例如移植排斥反应（ 例如，实体器官移植排斥反应，糖尿病胰岛细胞移植排斥反应，移植物抗宿主病（GVHD）等），自身免疫性疾病（例如关节炎，类风湿性关节炎，多发性硬化症，溃疡性结肠炎等） ），过敏性疾病（例如哮喘等），缺血性疾病（例如缺血再灌注损伤等），癌症或转移性疾病等。

    Chemokine Receptor Antagonist and Medical Use Thereof
    46.
    发明申请
    Chemokine Receptor Antagonist and Medical Use Thereof 失效
    趋化因子受体拮抗剂及其用途

    公开(公告)号：US20070254886A1

    公开(公告)日：2007-11-01

    申请号：US10570813

    申请日：2004-09-03

    申请人： Hiromu Habashita ,  Hiroshi Ochiai ,  Natsuko Tokuda ,  Shiro Shibayama ,  Noriki Watanabe ,  Takaki Komiya ,  Kazuhiko Takeda

    发明人： Hiromu Habashita ,  Hiroshi Ochiai ,  Natsuko Tokuda ,  Shiro Shibayama ,  Noriki Watanabe ,  Takaki Komiya ,  Kazuhiko Takeda

    IPC分类号： A61K31/4412 ,  A61K31/444 ,  A61K31/4965 ,  A61K31/498 ,  A61P11/06 ,  A61P17/00 ,  A61P31/00 ,  A61P9/00 ,  C07D213/72 ,  C07D241/22 ,  C07D241/44

    CPC分类号： C07D213/82 ,  C07D213/76 ,  C07D241/22 ,  C07D241/44 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc.), and the like], and the like.

    摘要翻译： 本发明涉及由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或前体药物及其医疗用途（式中的符号如说明书中所述）。 由式（I）表示的化合物具有趋化因子受体（特别是CCR4和/或CCR5）拮抗活性。 因此，可用于预防和/或治疗趋化因子受体介导的疾病如炎性和/或过敏性疾病[全身炎症反应综合征（SIRS），过敏反应，过敏反应，过敏性血管炎，移植排斥反应，肝炎，肾炎， 肾病，胰腺炎，鼻炎，关节炎，炎症性眼病，炎性肠病，脑脊液和/或循环系统疾病，呼吸系统疾病，皮肤病，自身免疫性疾病等），感染[病毒性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷 综合征，SARS等）等]等。

    Antagonist and agonist which bind to a strong binding site of chemokine receptor
    47.
    发明申请
    Antagonist and agonist which bind to a strong binding site of chemokine receptor 审中-公开
    拮抗剂和激动剂，其结合趋化因子受体的强结合位点

    公开(公告)号：US20060251651A1

    公开(公告)日：2006-11-09

    申请号：US10538364

    申请日：2003-12-12

    申请人： Shiro Shibayama ,  Kenji Sagawa ,  Noriki Watanabe ,  Kazuhiko Takeda ,  Hideaki Tada ,  Daikichi Fukushima

    发明人： Shiro Shibayama ,  Kenji Sagawa ,  Noriki Watanabe ,  Kazuhiko Takeda ,  Hideaki Tada ,  Daikichi Fukushima

    IPC分类号： A61K39/395 ,  G01N33/567 ,  C07K16/28

    CPC分类号： A61K31/49 ,  A61K31/00 ,  A61K31/503 ,  A61K31/5377 ,  G01N2333/715 ,  G01N2500/04

    摘要： An antagonist or an agonist which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method; an antagonist or an agonist which binds to a strong binding site of a chemokine receptor; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of a chemokine receptor; and a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method. The antagonist or the agonist of the present invention is useful as a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer.

    摘要翻译： 结合CCR5的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合CCR5的强结合位点的化合物的方法; 包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂; 结合趋化因子受体的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合趋化因子受体的强结合位点的化合物的方法; 以及包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。 本发明的拮抗剂或激动剂可用作过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。

    MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE
    48.
    发明申请
    MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE 有权
    细胞表面功能分子的细胞域的多个

    公开(公告)号：US20120269859A1

    公开(公告)日：2012-10-25

    申请号：US13486189

    申请日：2012-06-01

    申请人： Nagahiro Minato ,  Yoshimasa Tanaka ,  Shiro Shibayama

    发明人： Nagahiro Minato ,  Yoshimasa Tanaka ,  Shiro Shibayama

    IPC分类号： C07K14/435 ,  A61P35/00 ,  A61K39/00 ,  A61P37/00 ,  A61P31/00 ,  A61K38/17 ,  A61P35/04

    CPC分类号： C07K14/70503 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  A61K47/26 ,  C07K14/70532 ,  Y02A50/465 ,  Y02A50/481

    摘要： As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

    摘要翻译： 作为药理学上调节细胞表面功能分子的功能的物质，具有特异性，活性或功效等同于或优于抗体且不需要先进的生产技术的物质及其应用于药物的设备已经被 要求 本发明涉及细胞表面功能分子的细胞外结构域的多聚体，特别是PD-1或PD-L1细胞外结构域的四聚体。 此外，本发明涉及这样的四聚体作为癌症，癌症转移，免疫缺陷，感染性疾病等的预防和/或治疗剂的应用，以及应用PD-1或PD-L1作为检测或诊断 代理人或这种疾病的研究代理人。

    Multimer of extracellular domain of cell surface functional molecule
    49.
    发明授权
    Multimer of extracellular domain of cell surface functional molecule 有权
    细胞表面功能分子细胞外结构域的多聚体

    公开(公告)号：US08216996B2

    公开(公告)日：2012-07-10

    申请号：US12281427

    申请日：2007-03-02

    申请人： Nagahiro Minato ,  Yoshimasa Tanaka ,  Shiro Shibayama

    发明人： Nagahiro Minato ,  Yoshimasa Tanaka ,  Shiro Shibayama

    IPC分类号： A61K38/00

    CPC分类号： C07K14/70503 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  A61K47/26 ,  C07K14/70532 ,  Y02A50/465 ,  Y02A50/481

    摘要： As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

    摘要翻译： 作为药理学上调节细胞表面功能分子的功能的物质，具有特异性，活性或功效等同于或优于抗体且不需要先进的生产技术的物质及其应用于药物的设备已经被 要求 本发明涉及细胞表面功能分子的细胞外结构域的多聚体，特别是PD-1或PD-L1细胞外结构域的四聚体。 此外，本发明涉及这样的四聚体作为癌症，癌症转移，免疫缺陷，感染性疾病等的预防和/或治疗剂的应用，以及应用PD-1或PD-L1作为检测或诊断 代理人或这种疾病的研究代理人。