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    Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders
    47.
    发明授权
    Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders 有权
    用于预防和治疗骨相关疾病的取代苯并呋喃并烯和相关化合物

    公开(公告)号：US08686028B2

    公开(公告)日：2014-04-01

    申请号：US13127913

    申请日：2009-05-14

    申请人： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

    发明人： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

    IPC分类号： A61K31/352 ,  A61K31/4453 ,  C07D311/36 ,  C07D493/04

    CPC分类号： C07D493/04 ,  C07D311/36

    摘要： The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.

    摘要翻译： 本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基， 任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。 通式的化合物可用于预防和治疗骨相关疾病。

    EXTENDED RELEASE DOSAGE FORM OF ROPINIROLE
    48.
    发明申请
    EXTENDED RELEASE DOSAGE FORM OF ROPINIROLE 审中-公开
    扩展发布的ROPINIROLE的剂量形式

    公开(公告)号：US20110262537A1

    公开(公告)日：2011-10-27

    申请号：US13119410

    申请日：2009-09-29

    申请人： Premchand Nakhat ,  Venkatesh Joshi ,  Prashant Mandaogade ,  Girish Kumar Jain

    发明人： Premchand Nakhat ,  Venkatesh Joshi ,  Prashant Mandaogade ,  Girish Kumar Jain

    IPC分类号： A61K9/22 ,  A61K9/52 ,  B29C67/00 ,  A61K31/4045 ,  A61P25/16

    CPC分类号： A61K9/2086 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/4045

    摘要： There is provided an extended release tablet in tablet dosage form of ropinirole or salts thereof comprising a) an inner tablet of ropinirole or salts thereof optionally with other pharmaceutically acceptable excipients and b) an outer tablet of other pharmaceutically acceptable excipients. The invention also provides an extended release pharmaceutical composition comprising a core of ropinirole or salt thereof and outer mantle coating comprising one or more pharmaceutically acceptable excipients. The invention also relates to processes of preparing such compositions.

    摘要翻译： 提供了片剂剂型罗哌尼罗或其盐的延长释放片剂，其包含a）罗匹尼罗内片或任选与其它药学上可接受的赋形剂的盐，以及b）其它药学上可接受的赋形剂的外片剂。 本发明还提供了包含罗匹尼罗核心或其盐的延长释放药物组合物和包含一种或多种药学上可接受的赋形剂的外衣层涂层。 本发明还涉及制备这种组合物的方法。