公开(公告)号：USD284090S

公开(公告)日：1986-06-03

申请号：US597083

申请日：1984-04-05

申请人： Toshiaki Takizawa ,  Akio Tsuyuki

设计人： Toshiaki Takizawa ,  Akio Tsuyuki

公开(公告)号：US4580321A

公开(公告)日：1986-04-08

申请号：US741143

申请日：1985-06-04

申请人： Koichi Tanikawa ,  Toshiaki Takizawa

发明人： Koichi Tanikawa ,  Toshiaki Takizawa

IPC分类号： A44B19/02 ,  A44B19/32 ,  A44B19/34 ,  A44B19/40

CPC分类号： A44B19/32 ,  A44B19/34 ,  A44B19/40 ,  Y10T24/2505 ,  Y10T24/2514 ,  Y10T24/2521 ,  Y10T24/2527

摘要： A fluid-tight slide fastener comprises a pair of slide fastener halves each including a support tape, a row of continuous coupling elements extending longitudinally along the inner edge of the tape on one side thereof, and an elastomeric sealing member overlying the other side of the tape. The tape has a longitudinal ridge substantially defining the inner edge and supporting the row of coupling elements laterally longitudinally by means of stitching threads. A portion of the threads is disposed adjacent to the ridge to prevent the latter from moving remotely from the coupling elements row for thereby supporting the ridge intimately enough to ensure the abuttment of opposed sealing edges of the tapes when the fastener halves are coupled together.

摘要翻译： 流体密封拉链包括一对拉链半部，每个拉链半部包括支撑带，一排连续的连接元件，其沿着带的一侧的纵向延伸，以及弹性密封件， 胶带。 胶带具有基本上限定内边缘的纵向脊，并通过缝合螺纹横向地纵向地支撑一排联接元件。 螺纹的一部分设置成邻近脊，以防止其远离联接元件排移动，从而足够紧密地支撑脊，以便当紧固件半部联接在一起时确保带的相对的密封边缘的邻接。

公开(公告)号：USD262386S

公开(公告)日：1981-12-22

申请号：US79345

申请日：1979-09-27

申请人： Toshiaki Takizawa

设计人： Toshiaki Takizawa

公开(公告)号：US20120165377A1

公开(公告)日：2012-06-28

申请号：US13393164

申请日：2010-09-27

申请人： Toshiaki Takizawa ,  Kentaro Murakami

发明人： Toshiaki Takizawa ,  Kentaro Murakami

IPC分类号： A61K31/423 ,  A61P3/04 ,  A61P3/00 ,  C07D263/58

CPC分类号： A61K31/423 ,  C07D231/56 ,  C07D263/58 ,  C07D277/82

摘要： An FGF21 production promoting agent containing, as an active ingredient, a compound represented by the following formula (1): wherein each of R1 and R2, which may be identical to or different from each other, represents, for example, a hydrogen atom; each of R3a, R3b, R4a, and R4b, which may be identical to or different from one another, represents, for example, a hydrogen atom or a halogen atom, or R3a and R3b or R4a and R4b may bond together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents, for example, a hydrogen atom or a C1-4 alkyl group); Y represents, for example, an oxygen atom, an S(O)l group (l is a number of from 0 to 2), or a carbonyl group; Z represents CH or N; n is a number of from 1 to 6; and m is a number from 2 to 6, a salt of the compound, or a solvate of the compound or the salt.

摘要翻译： 一种FGF21生产促进剂，其含有下式（1）表示的化合物作为活性成分：其中可以相同或不同的R 1和R 2各自表示例如氢原子; 可以相同或不同的R 3a，R 3b，R 4a和R 4b各自表示例如氢原子或卤原子，或者R 3a和R 3b或R 4a和R 4b可以键合在一起形成亚烷基二氧基 组; X表示氧原子，硫原子或N-R5（R5表示例如氢原子或C1-4烷基）; Y表示例如氧原子，S（O）1基（1为0〜2的数）或羰基; Z表示CH或N; n是从1到6的数字; m为2〜6的数，化合物的盐或化合物或其盐的溶剂合物。

公开(公告)号：US20100069433A1

公开(公告)日：2010-03-18

申请号：US12593356

申请日：2008-03-28

申请人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

发明人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

IPC分类号： A61K31/47 ,  A61K31/42

CPC分类号： C07D263/58 ,  A61K31/423 ,  A61K31/47

摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.

摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖症或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由下式表示的化合物 （1）表示：其中：R 1和R 2可以相同或不同，各自表示氢原子，甲基或乙基; R3a，R3b，R4a和R4b可以相同或不同，分别表示氢原子，卤素原子，硝基，羟基，C1-4烷基，三氟甲基，C1-4烷氧基 ，C 1-4烷基羰基氧基，二-C 1-4烷基氨基，C 1-4烷基磺酰氧基，C 1-4烷基磺酰基，C 1-4烷基亚磺酰基或C 1-4烷硫基，或R 3a和R 3b ，或R4a和R4b连接以代表亚烷基二氧基; X表示氧原子，硫原子或N-R5（其中，R5表示氢原子，C1-4烷基，C1-4烷基磺酰基或C1-4烷氧基羰基）。 Y表示氧原子，S（O）1基（l表示0〜2的数），羰基，羰基氨基，氨基羰基，磺酰基氨基，氨基磺酰基或NH基。 Z表示CH或N; n表示1〜6的数; m代表2至6的数，或其盐，他汀类，特别是匹伐他汀组合。

公开(公告)号：US07033262B2

公开(公告)日：2006-04-25

申请号：US10668724

申请日：2003-09-22

申请人： Toshiaki Takizawa ,  Yoshinobu Takahashi

发明人： Toshiaki Takizawa ,  Yoshinobu Takahashi

IPC分类号： B24D17/00

CPC分类号： B24D9/085 ,  B24D9/08

摘要： An abrasive substrate is removably provided between a head portion and an abrasive member in a carry type abrasive machine. The abrasive substrate is constituted by a single synthetic resin molded member formed of the same material, and a hardness in a peripheral portion is set to be lower than that in a central portion excluding the peripheral edge portion. A difference in the hardness between the central portion and the peripheral portion is regulated by a concavo-convex surface formed on a surface at the fixing side to the head portion of the carry type abrasive machine. It is desirable that the concavo-convex surface should be constituted by a plurality of rib-shaped projections formed on the same plane. The abrasive substrate of the carry type abrasive machine can be manufactured inexpensively and can carry out a reliable and stable abrasion work.

摘要翻译： 磨料基材可移除地设置在进料型研磨机中的头部和研磨部件之间。 磨料基材由相同材料形成的单一合成树脂模塑构件构成，并且周边部分的硬度设定为低于除了周边部分之外的中心部分的硬度。 中心部分和周边部分之间的硬度差异是通过形成在携带型研磨机的头部的固定侧的表面上形成的凹凸表面来调节的。 希望凹凸表面应由形成在同一平面上的多个肋状突起构成。 携带式研磨机的磨料基材可以廉价制造，可以进行可靠稳定的磨损加工。

公开(公告)号：US4596065A

公开(公告)日：1986-06-24

申请号：US730541

申请日：1985-05-06

申请人： Koichi Tanikawa ,  Toshiaki Takizawa

发明人： Koichi Tanikawa ,  Toshiaki Takizawa

IPC分类号： A44B19/32 ,  A44B19/34 ,  B21D53/50 ,  A41H37/06

CPC分类号： A44B19/32 ,  A44B19/34 ,  Y10T29/49782 ,  Y10T29/5101

摘要： A method of producing a slide fastener wherein a series of fastener elements are secured to each of a pair of fastener tapes along one edge each thereof, each said fastener tape is formed thereon with a waterproof sealing layer, and when said series of fastener elements on each said pair of fastener tapes are engaged with each other, the edges of said waterproof sealing layers on each said pair of fastener tapes are press-contacted with each other so as to provide airtightness and waterproofness. The improvement comprises forming said pair of fastener tapes in one piece with a thin connecting portion therebetween, securing a pair of said series of fastener elements to one side of said pair of fastener tapes formed in one piece on the edges along both sides of said connecting portion so that they face each other without being engaged with each other, applying a resiliently deformable waterproof sealing layer all over the other side of said pair of fastener tapes formed in one piece including said connecting portion, then cutting said pair of fastener tapes formed in one piece away from each other longitudinally along said connecting portion so that each cut edge of said waterproof sealing layer projects over a line which will become the center line of engagement of said pair of series of fastener elements when they are engaged with each other. The above method according to the invention produces an airtight and waterproof slide fastener in a simplified manner without impairing the engaging function of the slide fastener and without rendering any damage to the fastener elements.

摘要翻译： 一种制造拉链的方法，其中一系列紧固元件沿其一个边缘固定到一对拉链带中的每一个上，每个所述拉链带在其上形成有防水密封层，并且当所述一系列紧固件元件在 每个所述一对拉链带彼此接合，所述一对拉链带上的所述防水密封层的边缘彼此压接，从而提供气密性和防水性。 改进之处在于，将一对拉链带形成为一体，其间具有薄的连接部分，将一对所述紧固件系列固定在所述一对拉链带的一侧，所述拉链带在所述连接 使得它们彼此面对而不彼此接合，在形成为包括所述连接部分的一个构件的所述一对拉链带的整个另一侧上施加可弹性变形的防水密封层，然后切割形成在其中的一对拉链带 沿着所述连接部分纵向彼此远离一个部分，使得所述防水密封层的每个切割边缘在彼此接合时将成为所述一对紧固件元件的接合中心线的线突出。 根据本发明的上述方法以简化的方式产生气密和防水拉链，而不损害拉链的接合功能，而不会对紧固件元件造成任何损坏。

公开(公告)号：US20060183664A1

公开(公告)日：2006-08-17

申请号：US10496851

申请日：2002-12-13

申请人： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

发明人： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

IPC分类号： A61K38/54

CPC分类号： A61K45/06 ,  A61K31/00 ,  Y02A50/423 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.

摘要翻译： 本发明通过新颖的作用机理提供药物组合物，对迟发性超敏反应没有严重的副作用及其筛选方法。 本发明还提供了PAR-2抑制剂/抑制剂的新型测定方法。 本发明涉及一种用于延迟超敏反应的药物组合物，其含有选自PAR-2的抑制剂和PAR-2基因表达的抑制剂的一种或两种以上活性成分和药学上可接受的载体，以及筛选方法 通过使受试物质与表达PAR-2的细胞接触并通过测定PAR-2的表达或活性来延迟超敏反应的药物组合物的活性成分。 本发明还涉及使用含有肌醇的培养物中表达PAR-2的细胞检测或定量PAR-2的物质的作用的方法。

公开(公告)号：US06877192B2

公开(公告)日：2005-04-12

申请号：US10058405

申请日：2002-01-30

申请人： Yutaka Tominaga ,  Toshiaki Takizawa

发明人： Yutaka Tominaga ,  Toshiaki Takizawa

IPC分类号： A44B19/00 ,  A44B19/12 ,  A44B19/34 ,  A44B19/42

CPC分类号： A44B19/42 ,  A44B19/12 ,  A44B19/34 ,  Y10T24/25 ,  Y10T24/2518 ,  Y10T24/2527

摘要： Both sides of a fastener chain may be reinforced and an attachment object such as a bag or a case may be mounted in a stabilized condition. A reinforcement member, which is molded of thermoplastic resin, thermoplastic elastomer or synthetic rubber in the form of a turned-down U shape in its cross section and has an appropriate plasticity and flexibility, is bonded along both outer sides of a fastener chain with a thermal welding resin film. The reinforcement member has a mounting groove which enables a cloth of the attachment object such as the bag or the case to be mounted and further contains a concave groove for a sewing thread, provided in the surface thereof. The cloth of the attachment object is inserted into the mounting groove and sewed along the concave groove with a sewing thread. Consequently, the reinforcement member can be mounted simply in a stabilized condition and can ensure a long term use.

摘要翻译： 紧固链条的两侧可以被加强，并且诸如袋或壳体的附接对象可以以稳定的状态安装。 由热塑性树脂，热塑性弹性体或其横截面呈倒U形的合成橡胶模制而成的具有适当塑性和柔韧性的增强件，沿着链条的两个外侧与 热熔树脂膜。 加强构件具有安装槽，其能够安装诸如袋或壳体的安装对象的布，并且在其表面中还包含用于缝纫线的凹槽。 将附着物的布插入安装槽中，并用缝纫线沿凹槽缝合。 因此，加强构件可以简单地安装在稳定状态，并且可以确保长期使用。

公开(公告)号：US06849961B2

公开(公告)日：2005-02-01

申请号：US10231030

申请日：2002-08-30

申请人： Toshiaki Takizawa ,  Tadahiro Yaguchi

发明人： Toshiaki Takizawa ,  Tadahiro Yaguchi

IPC分类号： F01P3/04 ,  F02B63/04 ,  H02P9/04

CPC分类号： F02B63/04

摘要： In an engine generator, a pair of wall plate members are opposed to each other at a distance. Accommodated between the wall plate members are an engine having a crankshaft perpendicular to the wall plate members; an outer-rotor type generator also serving as a flywheel and connected directly to the crankshaft; an intake system device disposed on one side of the engine in a plane perpendicular to an axis of the crankshaft; and an exhaust system device disposed on the other side of the engine in the plane. Thus, the engine generator can be accommodated in a limited space.

摘要翻译： 在发动机发电机中，一对壁板构件在一定距离处彼此相对。 容纳在壁板构件之间的是具有垂直于壁板构件的曲轴的发动机; 也用作飞轮并直接连接到曲轴的外转子式发电机; 在与所述曲轴的轴线垂直的平面内配置在所述发动机一侧的进气系统装置; 以及设置在发动机的另一侧的排气系统装置。 因此，发动机发电机可以容纳在有限的空间中。