公开(公告)号：US06384050B1

公开(公告)日：2002-05-07

申请号：US09284871

申请日：1999-04-22

申请人： Makoto Takemura ,  Hisashi Takahashi ,  Kenichi Kimura ,  Rie Miyauchi ,  Hitoshi Ohki ,  Katsuhiro Kawakami

发明人： Makoto Takemura ,  Hisashi Takahashi ,  Kenichi Kimura ,  Rie Miyauchi ,  Hitoshi Ohki ,  Katsuhiro Kawakami

IPC分类号： C07D40104

CPC分类号： C07D401/04 ,  C07D455/02 ,  C07D471/04 ,  C07D513/04

摘要： The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. wherein Q preferably represents the following partial structure which may have various substituents:

摘要翻译： 本发明涉及可具有各种取代基的三环胺取代基的化合物，该化合物由式（I）表示，其盐或水合物，以及该盐的水合物和含有它们作为有效成分的药物。 它们对革兰氏阴性细菌和革兰氏阳性菌表现出优异的抗微生物活性，具有令人满意的命运和安全性，可用于治疗感染性疾病。其中Q优选表示以下可能具有各种取代基的部分结构：

公开(公告)号：US6121285A

公开(公告)日：2000-09-19

申请号：US82155

申请日：1998-05-21

申请人： Makoto Takemura ,  Youichi Kimura ,  Hisashi Takahashi ,  Kenichi Kimura ,  Satoru Miyauchi ,  Hitoshi Ohki ,  Kazuyuki Sugita ,  Rie Miyauchi

发明人： Makoto Takemura ,  Youichi Kimura ,  Hisashi Takahashi ,  Kenichi Kimura ,  Satoru Miyauchi ,  Hitoshi Ohki ,  Kazuyuki Sugita ,  Rie Miyauchi

IPC分类号： C07D207/08 ,  C07D207/10 ,  C07D207/46 ,  C07D215/16 ,  C07D471/02

CPC分类号： C07D401/04 ,  C07D207/273 ,  C07D498/04

摘要： An antimicrobial drug having excellent antimicrobial activity and high safety is disclosed, which comprises as an active ingredient, a quinolone-derivative having a substituted aminocycloalkylpyrrolidine as a substituent and which is further substituted with various substituents, represented by formula (I), its salts and hydrates thereof: ##STR1## wherein Q is represented by formula (II) or (IV). ##STR2## Also disclosed is a quinolone derivative where R.sup.4 and the substituent on the pyrrolidine ring of the following formula: ##STR3## are located at the cis-configuration; and Q is represented by the formula: ##STR4##

摘要翻译： 公开了具有优异的抗微生物活性和高安全性的抗微生物药物，其包含作为活性成分的具有取代的氨基环烷基吡咯烷作为取代基的喹诺酮衍生物，并且还被式（I）表示的各种取代基，其盐和 其水合物：其中Q由式（II）或（IV）表示。 还公开了喹诺酮衍生物，其中R4和下式的吡咯烷环上的取代基位于顺式构型; Q由下式表示：

公开(公告)号：US5682269A

公开(公告)日：1997-10-28

申请号：US687023

申请日：1996-07-25

申请人： Kenichi Kimura ,  Makoto Sekita

发明人： Kenichi Kimura ,  Makoto Sekita

IPC分类号： G02B13/22 ,  G02B9/60 ,  G02B9/62 ,  G02B13/04

CPC分类号： G02B13/22 ,  G02B13/04 ,  G02B9/60 ,  G02B9/62

摘要： An objective lens device comprising in order from the lens closest to an object side, a negative meniscus first lens whose concave side faces the object side; a positive second lens; a positive meniscus third lens whose convex side faces an image side; a negative meniscus fourth lens whose concave side faces the object side; a negative meniscus fifth lens whose convex side faces the object side; and a positive sixth lens. The fifth and sixth lenses are cemented together to form a cemented lens subunit. The objective lens device contains six lenses in its entire lens structure, has a long back focus, and provides excellent optical properties over an entire field.

摘要翻译： 一种物镜装置，其从最靠近物体侧的透镜依次包括凹面朝向物体侧的负弯液面第一透镜; 一个正的第二个镜头; 凸面朝向图像侧的正弯月面第三透镜; 凹面朝向物体侧的负弯液面第四透镜; 凸面朝向物体侧的负弯液面第五透镜; 和正六号透镜。 将第五和第六透镜粘结在一起以形成胶合透镜子单元。 该物镜在其整个透镜结构中包含六个透镜，具有长的后焦距，并且在整个场上提供优异的光学性能。

公开(公告)号：US5388239A

公开(公告)日：1995-02-07

申请号：US668717

申请日：1991-03-12

申请人： Kenji Iimura ,  Sakae Miki ,  Shunji Shimada ,  Michio Hara ,  Kenjirou Yasunari ,  Hiroshi Takahashi ,  Kenichi Kimura ,  Akira Ikuta ,  Kenji Kawakita

发明人： Kenji Iimura ,  Sakae Miki ,  Shunji Shimada ,  Michio Hara ,  Kenjirou Yasunari ,  Hiroshi Takahashi ,  Kenichi Kimura ,  Akira Ikuta ,  Kenji Kawakita

IPC分类号： G06F9/355 ,  G06F13/00 ,  H04L29/06 ,  G06F12/12

CPC分类号： G06F9/342 ,  H04L29/06

摘要： A system of adding an operand address included in an instruction word to the contents of a modification register to obtain an effective address, wherein address data which designates each of a plurality of data tables constituted with prescribed storage capacity, is stored in a plurality of modification registers. Prescribed address data of one of the plurality of modification registers is selected based on the instruction word. The effective address for addressing the operand is obtained by adding the prescribed address data of the one of the plurality of modification registers to address data included in the operand address. The address data included in the operand address designates addresses which correspond to addresses of the plurality of data tables.

摘要翻译： 将包括在指令字中的操作数地址与修改寄存器的内容相加以获得有效地址的系统，其中指定以规定存储容量构成的多个数据表中的每一个的地址数据被存储在多个修改中 注册 基于指令字选择多个修改寄存器之一的规定地址数据。 用于寻址操作数的有效地址是通过将包括在操作数地址中的地址数据添加到多个修改寄存器中的一个的规定地址数据而获得的。 包括在操作数地址中的地址数据指定对应于多个数据表的地址的地址。

公开(公告)号：US5134524A

公开(公告)日：1992-07-28

申请号：US534241

申请日：1990-06-07

申请人： Hiroyuki Hamano ,  Kenichi Kimura ,  Saburo Sugawara

发明人： Hiroyuki Hamano ,  Kenichi Kimura ,  Saburo Sugawara

IPC分类号： G02B15/173

CPC分类号： G02B15/173

摘要： A zoom lens of the rear focus type is disclosed, comprising, from front to rear, a first lens group of positive power, a second lens group of negative power, a third lens group of positive power and a fourth lens group of positive power, wherein zooming from the wideangle end to the telephoto end is performed by axially moving the first, second and fourth lens groups in differential relation to one another, and focusing is performed by axially moving the fourth lens group alone.

摘要翻译： 公开了一种后焦点类型的变焦透镜，包括从前到后的正功率的第一透镜组，负功率的第二透镜组，正光焦度的第三透镜组和正光焦度的第四透镜组， 其中通过将第一，第二和第四透镜组彼此不相关地轴向移动来执行从广角端到望远端的放大，并且通过单独轴向移动第四透镜组来执行聚焦。

公开(公告)号：US09435728B2

公开(公告)日：2016-09-06

申请号：US13342233

申请日：2012-01-03

申请人： Ken Tsukii ,  Kenichi Kimura ,  Toru Takahashi ,  Jie Xu

发明人： Ken Tsukii ,  Kenichi Kimura ,  Toru Takahashi ,  Jie Xu

IPC分类号： B07C5/342 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L2300/0832 ,  B07C5/342 ,  G01N15/1404 ,  G01N2015/1438 ,  G01N2015/149

摘要： A sample identification/sorting apparatus includes a sample storage portion that stores samples dispersed in a liquid, a flow cell having a flow path through which the liquid flows, and a sorting nozzle that has a flow path communicating with the flow path of the flow cell and dispenses a sorting solution including the sample, which is a target sample, to a culture plate. A difference between a flow direction of the liquid at an outlet of the sample storage portion and a flow direction of the liquid at a leading end of the sorting nozzle is less than 90 degrees.

摘要翻译： 样品识别/分选装置包括存储分散在液体中的样品的样品存储部分，具有液体流过的流路的流通池，以及具有与流通池的流路连通的流路的分选喷嘴 并将包含作为目标样品的样品的分选溶液分配到培养板。 样品储存部分的出口处的液体的流动方向与分拣喷嘴前端的液体的流动方向之间的差小于90度。

公开(公告)号：US08685710B2

公开(公告)日：2014-04-01

申请号：US12187872

申请日：2008-08-07

申请人： Kenichi Kimura ,  Ken Tsukii ,  Shinichi Taguchi ,  Jie Xu ,  Motosuke Kiyohara

发明人： Kenichi Kimura ,  Ken Tsukii ,  Shinichi Taguchi ,  Jie Xu ,  Motosuke Kiyohara

IPC分类号： C12M1/34 ,  C12M3/00 ,  G02B6/00 ,  G01N21/00 ,  G01N21/01 ,  G01N21/64 ,  G01N21/66

CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N2021/6484

摘要： A photodetector detects fluorescence emitted from a sample placed on a substrate of a DNA chip. There is an irradiation optical system for guiding irradiation light by a first optical waveguide, gathering the irradiation light by a first lens and irradiating the sample. A reception optical system gathers fluorescence at an input-side end surface of a second optical waveguide by a second lens and guides the fluorescence to a measuring unit. The irradiation optical system and the reception optical system are separate light guiding paths. The reception optical system is of a confocal optical system in which a focal point on the sample is identical to a focal point at the input-side end surface of the second optical waveguide of the reception optical system.

摘要翻译： 光电检测器检测从放置在DNA芯片的基底上的样品发出的荧光。 存在用于通过第一光波导引导照射光的照射光学系统，通过第一透镜聚集照射光并照射样品。 接收光学系统通过第二透镜在第二光波导的输入侧端面收集荧光，并将荧光引导到测量单元。 照射光学系统和接收光学系统是分开的光导路径。 接收光学系统是共焦光学系统，其中样本上的焦点与接收光学系统的第二光波导的输入侧端面处的焦点相同。

公开(公告)号：US08345237B2

公开(公告)日：2013-01-01

申请号：US13335997

申请日：2011-12-23

申请人： Ken Tsukii ,  Kenichi Kimura ,  Toru Takahashi ,  Jie Xu

发明人： Ken Tsukii ,  Kenichi Kimura ,  Toru Takahashi ,  Jie Xu

IPC分类号： G01N21/00

CPC分类号： G01N15/1434 ,  G01N2015/1452

摘要： An optical information analyzing device includes an irradiating unit that irradiates irradiation light to specimens, a transmitted light receiving unit that receives transmitted light and detects the transmitted light as a transmitted light signal, a scattering/fluorescent light receiving unit that receives lateral scattering light and fluorescent light and detects the lateral scattering light and the fluorescent light as a scattering/fluorescent light signal, a nozzle position adjusting mechanism, and an analyzing unit that measures the optical information on the specimen on the basis of the detected transmitted light signal and the detected scattering/fluorescent light signal and analyzes the specimen.

摘要翻译： 光学信息分析装置包括：照射照射光的照射单元，接收透射光的透射光接收单元，并将透射光作为透射光信号进行检测;散射/荧光受光单元，其接收横向散射光和荧光 光并且检测作为散射/荧光信号的横向散射光和荧光，喷嘴位置调整机构和分析单元，其基于检测到的透射光信号和检测到的散射来测量样品上的光学信息 /荧光灯信号并分析样品。

公开(公告)号：US07999929B2

公开(公告)日：2011-08-16

申请号：US11659132

申请日：2005-08-01

申请人： Ken Tsukii ,  Jie Xu ,  Kenichi Kimura ,  Satoshi Sugiyama

发明人： Ken Tsukii ,  Jie Xu ,  Kenichi Kimura ,  Satoshi Sugiyama

IPC分类号： G01N21/00

CPC分类号： G01N21/6452 ,  G01N21/253 ,  G01N2201/08

摘要： A specimen optical information recognizing device includes a specimen containing section containing a specimen to be measured, a specimen measuring section having a light source for outputting light for observing the specimen, a photodetecting section for collecting optical information from the specimen, and an optical waveguide for propagating light between the specimen containing and the specimen measuring sections. The optical information on the specimen may be recognized by measuring values under at least two measurement conditions. The specimen optical information recognizing device includes a measurement auxiliary liquid interposed between the end of the optical waveguide and the specimen. A longitudinal cross section of the specimen containing section may be of a recessed shape, and the aperture depth of the recessed portion may be greater than the aperture diameter. A through hole may be provided at least in a part near the bottom of the specimen containing section.

摘要翻译： 样本光学信息识别装置包括：包含待测试样本的检体容纳部，具有用于输出用于观察样本的光的光源的检体测定部;检体的光信息的光检测部;光检测部 在载体和样品测量部分之间传播光。 可以通过在至少两个测量条件下测量值来识别样品上的光学信息。 样本光学信息识别装置包括介于光波导的端部和样本之间的测量辅助液体。 试样容纳部的纵截面可以是凹形，凹部的开口深度可以大于孔直径。 至少在样本容纳部的底部附近的部分设置通孔。

公开(公告)号：US20100231913A1

公开(公告)日：2010-09-16

申请号：US12403772

申请日：2009-03-13

申请人： Ken Tsukii ,  Jie Xu ,  Kenichi Kimura

发明人： Ken Tsukii ,  Jie Xu ,  Kenichi Kimura

IPC分类号： G01N21/00

CPC分类号： G01N21/645 ,  G01N15/1434 ,  G01N15/1459

摘要： An optical measurement apparatus can be provided, in which the sample is optically measured without loss of the illuminating light with high sensitivity. A glass plate as the transparent member 50 is placed in the interface between the end face 43 of the optical waveguide 40 guiding the illuminating light L generated by the laser light source 20 and the wall face of the capillary 30. According to the above feature, the air layer is prevented from existing in the interface between the end face 43 of the optical fiber 40 and the wall face of the capillary 30, thus the sample S can be optically measured with high sensitivity and few variability without causing the loss of the illuminating light L.

摘要翻译： 可以提供光学测量装置，其中在没有损失高灵敏度的照明光的情况下光学测量样品。 作为透明构件50的玻璃板被放置在引导由激光光源20产生的照明光L和毛细管30的壁面的光波导40的端面43之间的界面中。根据上述特征， 防止空气层存在于光纤40的端面43与毛细管30的壁面之间的界面中，因此可以以高灵敏度和少量的变化光学测量样品S，而不会导致照射损失 光L.