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公开(公告)号：US07332490B2
公开(公告)日：2008-02-19
申请号：US11441326
申请日：2006-05-25
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： C07D251/70 , C07D251/52 , C07D401/12 , C07D403/12 , A61K31/53 , A61P35/00
CPC分类号： A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法和组合物。 特别地，本发明涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明涉及抑制平滑肌增殖的化合物。 特别地，本发明涉及通过调节HSPG例如Perlecan抑制平滑肌细胞增殖的化合物。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。
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公开(公告)号：US07332489B2
公开(公告)日：2008-02-19
申请号：US10528724
申请日：2003-03-26
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： C07D251/70 , C07D403/12 , C07D401/12 , A61K31/53 , A61P35/00
CPC分类号： C07D413/04 , A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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公开(公告)号：US07238692B2
公开(公告)日：2007-07-03
申请号：US10951120
申请日：2004-09-27
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krisha Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krisha Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： A61M31/00 , A61F2/86 , C07D251/70 , C07D251/52 , C07D251/30
CPC分类号： A61K31/53 , C04B35/632 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法和组合物。 特别地，本发明涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明涉及抑制平滑肌增殖的化合物。 特别地，本发明涉及通过调节HSPG例如Perlecan抑制平滑肌细胞增殖的化合物。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。
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公开(公告)号：US20070122444A1
公开(公告)日：2007-05-31
申请号：US11512863
申请日：2006-08-30
申请人： Richard Timmer , Christopher Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Alluri , Koteswar Yeleswarapu , Manojit Pal , Jangalgar Reddy , Velagala Rama Murali Krishna Reddy , Potlapally Kumar , Gaddam Reddy
发明人： Richard Timmer , Christopher Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Alluri , Koteswar Yeleswarapu , Manojit Pal , Jangalgar Reddy , Velagala Rama Murali Krishna Reddy , Potlapally Kumar , Gaddam Reddy
IPC分类号： A61K31/675 , A61K31/55 , A61K31/541 , A61K31/53
CPC分类号： A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.
摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法，化合物和组合物，并且涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明还涉及抑制平滑肌增殖的化合物，例如通过调节HSPG如Perlecan。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。 本发明还涉及包括设置在医疗装置上或内部的本发明的化合物或组合物的医疗装置，例如支架。
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公开(公告)号：US20070099874A1
公开(公告)日：2007-05-03
申请号：US10528724
申请日：2003-03-26
申请人： Richard Timmer , Christopher Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Yeleswarapu , Manojit Pal , Jangalgar Reddy , Velagala Venkata Rama Reddy , Sesha Alluri , Potlapally Kumar , Gaddam Reddy
发明人： Richard Timmer , Christopher Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Yeleswarapu , Manojit Pal , Jangalgar Reddy , Velagala Venkata Rama Reddy , Sesha Alluri , Potlapally Kumar , Gaddam Reddy
IPC分类号： C07D403/02 , A61K31/675 , A61K31/53
CPC分类号： C07D413/04 , A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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公开(公告)号：US20070043051A1
公开(公告)日：2007-02-22
申请号：US11543969
申请日：2006-10-05
IPC分类号： A61K31/53 , C07D403/14
CPC分类号： C07D413/04 , A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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公开(公告)号：US06887712B1
公开(公告)日：2005-05-03
申请号：US09436892
申请日：1999-11-09
申请人： Russell M. Medford , Uday Saxena
发明人： Russell M. Medford , Uday Saxena
CPC分类号： A61K31/00 , G01N33/92 , G01N2800/044 , Y10S436/805 , Y10S436/815 , Y10T436/12
摘要： A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol. The method provided includes assessing the ability of the compound to form a complex with the lipoprotein, and then determining whether the newly formed complex causes a change in the structure of apoB-100 that results in increased binding affinity to an LDL receptor.
摘要翻译： 公开了一种用于确定化合物是否以降低血浆胆固醇的方式与脂蛋白如LDL或VLDL结合的方法。 所提供的方法包括评估化合物与脂蛋白形成复合物的能力，然后确定新形成的复合物是否导致apoB-100的结构改变，导致对LDL受体的结合亲和力的增加。
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公开(公告)号：US06656699B2
公开(公告)日：2003-12-02
申请号：US09952648
申请日：2001-09-14
申请人： Sivaram Pillarisetti , Uday Saxena , Dongyan Wang
发明人： Sivaram Pillarisetti , Uday Saxena , Dongyan Wang
IPC分类号： C12Q134
CPC分类号： G01N33/573 , G01N33/574 , G01N33/57484 , G01N2333/924
摘要： The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.
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