公开(公告)号：US20060073154A1

公开(公告)日：2006-04-06

申请号：US10233074

申请日：2002-08-30

申请人： Patricia Ryan ,  Vijay Pancholi ,  Vincent Fischetti

发明人： Patricia Ryan ,  Vijay Pancholi ,  Vincent Fischetti

IPC分类号： A61K39/40 ,  A61K39/02 ,  G01N33/554 ,  G01N33/569 ,  C07K14/315

CPC分类号： C12Q1/18 ,  A61K38/00 ,  C07K14/315 ,  C07K16/1275 ,  G01N33/56944 ,  G01N2500/00

摘要： The present invention comprises methods of inhibiting the interaction between group A streptococci or M protein and mucin or mucin producing cells by interfering with binding of M protein to sialic acid moieties of mucin, as well as methods of identifying modulators (e.g., inhibitors) of the interaction and novel M-protein binding receptors and mucin binding receptors. Also provided are methods of treating a group A streptococcal infection by inhibiting the interaction as well as pharmaceutical compositions which may be useful for this purpose.

摘要翻译： 本发明包括通过干扰M蛋白与粘蛋白的唾液酸部分的结合来抑制A组链球菌或M蛋白与产生粘蛋白或粘蛋白的细胞之间的相互作用的方法，以及鉴定调节剂（例如抑制剂）的方法 相互作用和新型M蛋白结合受体和粘蛋白结合受体。 还提供了通过抑制相互作用以及可能用于该目的的药物组合物来治疗A组链球菌感染的方法。

公开(公告)号：US20050208038A1

公开(公告)日：2005-09-22

申请号：US10869751

申请日：2004-06-16

申请人： Vincent Fischetti ,  Jutta Loeffler ,  Daniel Nelson

发明人： Vincent Fischetti ,  Jutta Loeffler ,  Daniel Nelson

IPC分类号： A61K38/46 ,  A61K38/48 ,  C12P21/06

CPC分类号： A61K38/47 ,  A61K38/162 ,  C12Q1/18 ,  C12Y302/01017 ,  G01N2333/3156 ,  A61K2300/00

摘要： The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Streptococcus pneumonia bacteria and spores, and related conditions. The disclosure further relates to methods and compositions for the identification of a phage associated lytic enzyme to rapidly kill Streptococcus pneumoniae and other bacteria. Related articles of manufacture, methods of degrading spores and methods of treatment of infections or bacteria populations of, or subjects exposed to or at risk for exposure to, Streptococcus pneumoniae are also provided.

摘要翻译： 本公开涉及可用于治疗肺炎链球菌和孢子的方法，组合物和制品以及相关条件。 本公开还涉及用于鉴定噬菌体相关裂解酶以快速杀死肺炎链球菌和其他细菌的方法和组合物。 还提供了相关制造方法，降低孢子的方法和治疗感染或细菌群体或暴露于或有暴露于肺炎链球菌风险的受试者的方法。

公开(公告)号：US06432444B1

公开(公告)日：2002-08-13

申请号：US09671878

申请日：2000-09-28

申请人： Vincent Fischetti ,  Lawrence Loomis

发明人： Vincent Fischetti ,  Lawrence Loomis

IPC分类号： A61K3843

CPC分类号： C12N9/503 ,  A61K9/0014 ,  A61K38/00 ,  A61L15/00 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/948

摘要： A bandage for treating a bacterial infection of skin is disclosed wherein the bandage contains a composition produced by the method of obtaining an effective amount of at least one lytic enzyme genetically coded for by a specific bacteriophage specific for a bacteria infecting the skin, wherein the bacteria to be treated is selected from the group consisting of Staphylococcus, Pseudomonas, Streptococcus, and combinations thereof. This lytic enzyme is specific for and has the ability to digest a cell wall of one of the bacteria and is coded for by the same bacteriophage capable of infecting the bacteria being digested. The enzyme produced is mixed with a topical carrier.

摘要翻译： 公开了一种用于治疗皮肤细菌感染的绷带，其中绷带包含通过获得有效量的至少一种裂解酶产生的组合物，所述至少一种裂解酶由感染皮肤的细菌特异性噬菌体进行遗传编码，其中细菌 待处理选自葡萄球菌属，假单胞菌属，链球菌属，及其组合。 该溶解酶对细菌的细胞壁是特异性的，并具有消化细菌的细胞壁的能力，并被能够感染被消化的细菌的相同噬菌体编码。 所产生的酶与局部载体混合。

公开(公告)号：US06428784B1

公开(公告)日：2002-08-06

申请号：US09671881

申请日：2000-09-28

申请人： Vincent Fischetti ,  Lawrence Loomis

发明人： Vincent Fischetti ,  Lawrence Loomis

IPC分类号： A61K3843

CPC分类号： A61K9/00 ,  A61K38/00 ,  C12N9/503 ,  Y02A50/473 ,  Y02A50/481 ,  Y10S514/937 ,  Y10S514/948

摘要： A composition for treatment of bacterial infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The lytic enzyme is which is specific for the group B Streptococcus, is genectically coded for by a specific bacteriophage.

摘要翻译： 公开了一种用于治疗阴道细菌感染的组合物，其包含对感染细菌特异性的溶解酶组合物和用于递送所述溶解酶的载体。 溶血酶对于B族链球菌是特异性的，由特异性噬菌体进行遗传编码。

公开(公告)号：US06423299B1

公开(公告)日：2002-07-23

申请号：US09654483

申请日：2000-09-01

申请人： Vincent Fischetti ,  Lawrence Loomis

发明人： Vincent Fischetti ,  Lawrence Loomis

IPC分类号： A61K912

CPC分类号： C12N9/503 ,  A61K38/00 ,  Y02A50/473 ,  Y02A50/481 ,  Y10S514/937

摘要： An aerosol composition for treating bacterial infections of the respiratory tract by delivering said aerosol to the mouth, throat or nasal passage, wherein the bacteria to be treated is selected from the group consisting of Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus Group A, and combinations thereof, said aerosol comprising an effective amount of at least one lytic enzyme genetically coded by a bacteriophage specific for a specific said bacteria of the respiratory tract, whereby said at least one lytic enzyme has the ability to digest the cell wall of said specific bacteria; and a carrier for delivering said enzyme.

摘要翻译： 一种气溶胶组合物，用于通过将所述气溶胶递送到口腔，喉部或鼻道中来治疗呼吸道的细菌感染，其中待治疗的细菌选自肺炎链球菌，流感嗜血杆菌，A组链球菌及其组合 所述气雾剂包含有效量的至少一种溶解酶，所述裂解酶由对特定所述呼吸道细菌特异的噬菌体进行遗传编码，由此所述至少一种裂解酶具有消化所述特定细菌的细胞壁的能力; 和用于递送所述酶的载体。