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    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof
    2.
    发明授权
    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof 有权
    C1噬菌体的核酸和多肽及其用途

    公开(公告)号：US07582729B2

    公开(公告)日：2009-09-01

    申请号：US10556359

    申请日：2004-05-14

    申请人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    发明人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    IPC分类号： C07K14/00

    CPC分类号： C12N9/503

    摘要： The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application. The specific regions of the C1 genome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.

    摘要翻译： C1噬菌体的全长核酸序列在本申请中公开。 编码PlyC溶素的C1基因组的特定区域也已被鉴定并测序。 本发明涉及这些序列的药物和诊断实用性，并且提供用于治疗或预防哺乳动物中链球菌感染的药物组合物的开发，用于无生物表面净化的组合物和用于诊断链球菌感染的组合物。

    Method of treating upper resiratory illnesses
    4.
    发明授权
    Method of treating upper resiratory illnesses 失效
    治疗上呼吸道疾病的方法

    公开(公告)号：US06752988B1

    公开(公告)日：2004-06-22

    申请号：US09560650

    申请日：2000-04-28

    申请人： Vincent Fischetti ,  Lawrence Loomis

    发明人： Vincent Fischetti ,  Lawrence Loomis

    IPC分类号： A61K3843

    CPC分类号： A61K38/162 ,  A61K38/47 ,  Y02A50/473 ,  Y02A50/481 ,  A61K2300/00

    摘要： A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a native or modified version of a lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria. The lytic enzyme is selected from a group consisting of shuffled lytic enzymes, chimericlytic enzymes, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. Additionally, a holin enzyme for puncturing the membrane may be included in the composition. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.

    摘要翻译： 公开了一种用于预防和治疗细菌感染的方法，其包括用有效量的由所述细菌特异性噬菌体感染的细菌产生的裂解酶的天然或修饰形式处理个体。 溶解酶选自洗牌溶解酶，嵌合分解酶，其中溶解酶在具有允许所述溶解酶活性的pH的环境中; 和用于递送所述裂解酶的载体。 另外，用于穿刺膜的胃蛋白酶可以包括在组合物中。 该方法和组合物可用于治疗上呼吸道感染，皮肤感染，伤口和烧伤，阴道感染，眼睛感染，肠道疾病和牙齿问题。

    Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract
    5.
    发明授权
    Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract 有权
    使用细菌噬菌体相关的裂解酶治疗上呼吸道的链球菌感染

    公开(公告)号：US06326002B1

    公开(公告)日：2001-12-04

    申请号：US09671990

    申请日：2000-09-28

    申请人： Vincent Fischetti ,  Lawrence Loomis

    发明人： Vincent Fischetti ,  Lawrence Loomis

    IPC分类号： A61K3800

    摘要： The present invention discloses a method for treating Streptococcal infections of the upper respiratory tract, comprising administering an effective amount of a lysin enzyme produced by group C Streptococcal bacteria infected with a C1 bacteriophage specific for the bacteria to a mouth, throat, or nasal passage of a mammal, the method providing a concentration of from about 100 to 500,000 active enzyme units per milliliter of fluid in the environment of said nasal or oral passages.

    摘要翻译： 本发明公开了一种治疗上呼吸道链球菌感染的方法，其特征在于，将由感染了细菌特异性的C1噬菌体的C组链球菌细菌产生的有效量的赖氨酸酶给予口腔，咽喉或鼻腔通道 哺乳动物，该方法在所述鼻腔或口腔通道的环境中提供浓度为约100至500,000活性酶单位/毫升流体。