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    Hemocompatible polymers on hydrophobic porous polymers
    41.
    发明授权
    Hemocompatible polymers on hydrophobic porous polymers 有权
    疏水多孔聚合物上的血液相容性聚合物

    公开(公告)号：US07807210B1

    公开(公告)日：2010-10-05

    申请号：US10818927

    申请日：2004-04-05

    Applicant: Wouter E. Roorda ,  Niraj Shah ,  André-Jean Lundkvist

    Inventor： Wouter E. Roorda ,  Niraj Shah ,  André-Jean Lundkvist

    IPC: A61L33/00 ,  A61L33/10 ,  A61F2/06

    CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L31/048 ,  A61L31/08 ,  A61L31/10 ,  A61L31/146 ,  A61L33/0011 ,  A61L2300/208 ,  A61L2300/236 ,  A61L2300/42 ,  C08L27/18

    Abstract: The present invention relates to providing a porous, hydrophobic polymer with a hemocompatible substance and to the materials produced thereby. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrochlorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation. A typical example providing a heparin complex to an endoluminal stent, consisting of coating DURAFLO onto an ePTFE stent-covering material.

    Abstract translation: 本发明涉及提供具有血液相容性物质的多孔疏水性聚合物及其制备的材料。 本发明的一个实施方案涉及提供具有一种或多种肝素复合物的膨胀聚（四氟乙烯），其通常含有与疏水性抗衡离子组合的肝素。 将血液相容性物质溶解在其中第一溶剂润湿待涂覆的聚合物的溶剂混合物中，并且第二溶剂增强溶血混合物中血液相容性物质物质的溶解度。 典型的第一溶剂润湿疏水性聚合物包括非极性如氢氯氟烃。 典型的第二溶剂包括极性溶剂如有机醇和酮。 在本发明的一些实施方案中使用第一溶剂中的第二溶剂的共沸混合物，尽管可以在小于0.1％至饱和的浓度范围内使用第二溶剂。 向肝内支架提供肝素复合物的典型例子包括将DURAFLO涂覆在ePTFE支架覆盖材料上。

    Device And Active Component For Inhibiting Formation Of Thrombus-Inflammatory Cell Matrix
    43.
    发明申请
    Device And Active Component For Inhibiting Formation Of Thrombus-Inflammatory Cell Matrix 审中-公开
    用于抑制凝血细胞炎症细胞基质形成的装置和活性成分

    公开(公告)号：US20080167711A1

    公开(公告)日：2008-07-10

    申请号：US12052645

    申请日：2008-03-20

    Applicant: Wouter E. Roorda

    Inventor： Wouter E. Roorda

    IPC: A61F2/82

    CPC classification number: A61L31/10 ,  A61L33/0011 ,  A61L33/0041 ,  A61L33/0064 ,  A61L33/04 ,  A61L33/064 ,  C08L29/04 ,  C08L33/12

    Abstract: A combination drug treatment for inhibiting stenosis or restenosis is disclosed. The combination treatment is an active component containing both an anti-inflammatory substance and an anti-thrombotic substance which, together, contribute to an inhibiting effect on the initial stages of stenosis or restenosis. The active component can be delivered to a site of treatment by being carried on a device, such as a stent.

    Abstract translation: 公开了用于抑制狭窄或再狭窄的组合药物治疗。 联合治疗是含有抗炎物质和抗血栓形成物质的活性成分，其一起有助于对狭窄或再狭窄的初始阶段的抑制作用。 活性成分可以通过携带在诸如支架的装置上而输送到治疗部位。

    THROMBUS PENETRATING DEVICES, SYSTEMS, AND METHODS
    48.
    发明申请
    THROMBUS PENETRATING DEVICES, SYSTEMS, AND METHODS 有权
    THROMBUS PENETRATING DEVICES，SYSTEMS和METHODS

    公开(公告)号：US20130060269A1

    公开(公告)日：2013-03-07

    申请号：US13227071

    申请日：2011-09-07

    Applicant: Wouter E. Roorda ,  Aaron M. Fortson

    Inventor： Wouter E. Roorda ,  Aaron M. Fortson

    IPC: A61B17/22

    CPC classification number: A61B17/320725 ,  A61B18/04 ,  A61B2017/00867 ,  A61B2017/22094

    Abstract: A device for penetrating occlusive material in a body lumen is provided that may include an outer tube, an intermediate tube, and an inner tube. At least a portion of the intermediate tube may be moveably disposed within the outer tube. At least a portion of the inner tube may be moveably disposed within the intermediate tube. A first dynamic member may be operably connected to the intermediate tube and the inner tube. The first dynamic member may be configured to penetrate the occlusive material and to anchor the first dynamic member within the occlusive material. A second dynamic member may be operably connected to the outer tube and the intermediate tube. The second dynamic member may be configured to penetrate the occlusive material and to anchor the second dynamic member within the occlusive material and to support movement of the first dynamic member.

    Abstract translation: 提供一种用于穿透体腔内的封闭材料的装置，其可以包括外管，中间管和内管。 中间管的至少一部分可以可移动地设置在外管内。 内管的至少一部分可以可移动地设置在中间管内。 第一动态构件可以可操作地连接到中间管和内管。 第一动态构件可以构造成穿透封闭材料并将第一动态构件锚定在封闭材料内。 第二动态构件可以可操作地连接到外管和中间管。 第二动态构件可以构造成穿透封闭材料并将第二动态构件锚定在封闭材料内并且支撑第一动态构件的移动。

    DEVICES AND METHODS FOR SUTURING TISSUE
    49.
    发明申请
    DEVICES AND METHODS FOR SUTURING TISSUE 有权
    用于组织组织的装置和方法

    公开(公告)号：US20120296347A1

    公开(公告)日：2012-11-22

    申请号：US13111416

    申请日：2011-05-19

    Applicant: Wouter E. Roorda ,  Laveille Kao Voss ,  David J. Milazzo ,  Aaron M. Fortson

    Inventor： Wouter E. Roorda ,  Laveille Kao Voss ,  David J. Milazzo ,  Aaron M. Fortson

    IPC: A61B17/04

    CPC classification number: A61B17/0469 ,  A61B17/0057 ,  A61B17/0482 ,  A61B17/0483 ,  A61B2017/00663 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0496

    Abstract: A suture applying device includes a shaft which carries a pair of needles near its distal end. The needles are joined by a length of suture, and the shaft is used to both introduce the needles into a lumen of a body structure and to draw the needles back through tissue on either side of the puncture site. After the needles have passed through the tissue, they are captured by a needle receiver and drawn outward through the tract, leaving a loop of suture behind to close the puncture site near the body lumen. The suture can then be tied or otherwise secured to close the puncture site.

    Abstract translation: 缝合施加装置包括在其远端附近承载一对针的轴。 针通过一定长度的缝合线连接，并且该轴用于将针引入体结构的内腔中，并且将针回穿穿刺部位两侧的组织。 针穿过组织后，它们被针头接收器捕获并向外穿过管道，留下一条缝合线，以闭合身体内腔附近的穿刺部位。 然后可以将缝合线绑定或以其他方式固定以关闭穿刺部位。

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