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    Targeting regulatory T cells with heterodimeric proteins
    44.
    发明授权
    Targeting regulatory T cells with heterodimeric proteins 有权

    公开(公告)号：US10519242B2

    公开(公告)日：2019-12-31

    申请号：US14214475

    申请日：2014-03-14

    Applicant: Xencor, Inc.

    Inventor： Seung Chu ,  Matthew Bernett ,  Dilki Wickramarachchi ,  John Desjarlais

    IPC: C12P21/08 ,  C07K16/28

    Abstract: The present invention provides methods and compositions comprising a heterodimeric antibody comprising a first monomer comprising a first variant heavy chain constant region and an anti-CD4 binding moiety. The heterodimeric antibody also comprises a second monomer comprising: a second variant heavy chain constant region and an anti-CD25 binding moiety. In some cases, the pIs of the first and second variant heavy chain constant regions are at least 0.5 logs apart.

    TRISPECIFIC ANTIBODIES
    45.
    发明申请
    TRISPECIFIC ANTIBODIES 审中-公开

    公开(公告)号：US20190352416A1

    公开(公告)日：2019-11-21

    申请号：US16530946

    申请日：2019-08-02

    Applicant: Xencor, Inc.

    Inventor： Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Sung-Hyung Lee

    IPC: C07K16/28

    Abstract: Provided herein are trispecific antibodies that include a) a first monomer, b) a second monomer, and c) a light chain. The first monomer includes a first variant Fc domain and a variable heavy domain, the second monomer includes a second variant Fc domain and a first scFv domain and the light chain includes a variable light domain. The variable heavy domain and the variable light domain form an antigen binding domain. The trispecific antibody further includes a second scFv domain on either the first or second monomers.

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