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    Targeting regulatory T cells with heterodimeric proteins
    42.
    发明授权
    Targeting regulatory T cells with heterodimeric proteins 有权

    公开(公告)号：US10519242B2

    公开(公告)日：2019-12-31

    申请号：US14214475

    申请日：2014-03-14

    Applicant: Xencor, Inc.

    Inventor： Seung Chu ,  Matthew Bernett ,  Dilki Wickramarachchi ,  John Desjarlais

    IPC: C12P21/08 ,  C07K16/28

    Abstract: The present invention provides methods and compositions comprising a heterodimeric antibody comprising a first monomer comprising a first variant heavy chain constant region and an anti-CD4 binding moiety. The heterodimeric antibody also comprises a second monomer comprising: a second variant heavy chain constant region and an anti-CD25 binding moiety. In some cases, the pIs of the first and second variant heavy chain constant regions are at least 0.5 logs apart.

    TRISPECIFIC ANTIBODIES
    43.
    发明申请
    TRISPECIFIC ANTIBODIES 审中-公开

    公开(公告)号：US20190352416A1

    公开(公告)日：2019-11-21

    申请号：US16530946

    申请日：2019-08-02

    Applicant: Xencor, Inc.

    Inventor： Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Sung-Hyung Lee

    IPC: C07K16/28

    Abstract: Provided herein are trispecific antibodies that include a) a first monomer, b) a second monomer, and c) a light chain. The first monomer includes a first variant Fc domain and a variable heavy domain, the second monomer includes a second variant Fc domain and a first scFv domain and the light chain includes a variable light domain. The variable heavy domain and the variable light domain form an antigen binding domain. The trispecific antibody further includes a second scFv domain on either the first or second monomers.

    TARGETING REGULATORY T CELLS WITH HETERODIMERIC PROTEINS
    50.
    发明申请
    TARGETING REGULATORY T CELLS WITH HETERODIMERIC PROTEINS 审中-公开
    用高分子蛋白质靶向调节性T细胞

    公开(公告)号：US20140294836A1

    公开(公告)日：2014-10-02

    申请号：US14214475

    申请日：2014-03-14

    Applicant: Xencor, Inc.

    Inventor： Seung Chu ,  Matthew Bernett ,  Dilki Wickramarachchi

    IPC: C07K16/28

    CPC classification number: C07K16/2866 ,  C07K16/2812 ,  C07K2317/31 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732

    Abstract: The present invention provides methods and compositions comprising a heterodimeric antibody comprising a first monomer comprising a first variant heavy chain constant region and an anti-CD4 binding moiety. The heterodimeric antibody also comprises a second monomer comprising: a second variant heavy chain constant region and an anti-CD25 binding moiety. In some cases, the pIs of the first and second variant heavy chain constant regions are at least 0.5 logs apart.

    Abstract translation: 本发明提供包含异二聚体抗体的方法和组合物，所述异二聚体抗体包含包含第一变体重链恒定区和抗CD4结合部分的第一单体。 异二聚体抗体还包含第二单体，其包含：第二变体重链恒定区和抗CD25结合部分。 在一些情况下，第一和第二变体重链恒定区的pI至少为0.5log。

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