公开(公告)号：US06239599B1

公开(公告)日：2001-05-29

申请号：US09316344

申请日：1999-05-21

申请人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff

发明人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff

IPC分类号： G01V300

CPC分类号： G01R33/58 ,  G01R33/56518 ,  G01R33/56554

摘要： A technique is disclosed for determining errors in MRI sequences resulting from eddy currents generated by pulsed gradient fields. During a calibration sequence, with no phase-encoding, gradient pulses and readout sequences are applied along physical axes of a scanner and data sets are acquired for each combination. A reference data set is acquired with no gradient pulses applied. The resulting data sets are processed by one dimensional Fourier transformation, and the transformed data is analyzed to determine spatially invariant and linear gradient errors. The phase errors may be averaged for each physical axis. The technique is particularly useful in determining errors in diffusion weighted echo planar imaging sequences.

摘要翻译： 公开了一种用于确定由脉冲梯度场产生的涡流产生的MRI序列中的误差的技术。 在校准序列期间，没有相位编码，沿着扫描仪的物理轴施加梯度脉冲和读出序列，并为每个组合采集数据集。 在不施加梯度脉冲的情况下获取参考数据集。 通过一维傅里叶变换处理所得到的数据集，并分析变换数据以确定空间不变和线性梯度误差。 每个物理轴可以对相位误差进行平均。 该技术在确定扩散加权回波平面成像序列中的误差方面特别有用。

公开(公告)号：US6057685A

公开(公告)日：2000-05-02

申请号：US987594

申请日：1997-12-09

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： G01R33/567 ,  G01V3/00

CPC分类号： G01R33/56509 ,  G01R33/5676

摘要： In a method for providing an MR image of a section taken through an object, wherein the section is acquired in the presence of in-plane translational motion of the object, an MR system is operated to acquire a set of imaging data points from the section, the set of imaging data points being contaminated by phase errors resulting from the motion. The MR system is further operated to acquire a plurality of correction data point sets, each correction data point in one of said sets being acquired along an alignment line or other trajectory and at a location coinciding with the location of one of the imaging data points. The imaging data points respectively coinciding with the correction data points comprise, collectively, a subset of the imaging data points. The phase difference between each correction data point set and its corresponding subset of imaging data points is determined, and then used to remove the phase errors from the set of imaging data points.

摘要翻译： 在用于提供通过对象拍摄的部分的MR图像的方法中，其中在存在对象的平面内平移运动的情况下获取该部分，操作MR系统以从该部分获取一组成像数据点 ，该组成像数据点被运动产生的相位误差污染。 进一步操作MR系统以获取多个校正数据点集合，其中一个组中的每个校正数据点沿着对准线或其他轨迹以及与一个成像数据点的位置重合的位置获取。 分别与校正数据点一致的成像数据点总共包括成像数据点的子集。 确定每个校正数据点集合及其对应的成像数据点子集之间的相位差，然后用于从成像数据点集合中去除相位误差。

公开(公告)号：US6011392A

公开(公告)日：2000-01-04

申请号：US5768

申请日：1998-01-12

申请人： Xiaohong Zhou ,  Matthew A. Bernstein ,  Gousheng Tan

发明人： Xiaohong Zhou ,  Matthew A. Bernstein ,  Gousheng Tan

IPC分类号： G01R33/561 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56581 ,  G01R33/56554 ,  G01R33/5617

摘要： Fast spin echo pulse sequences are adjusted to reduce, or eliminate image artifacts caused by Maxwell terms arising from the linear imaging gradients. The waveforms of the slice selection, phase encoding and readout gradients are adjusted in shape, size or position to eliminate or reduce the phase error caused by the spatially quadratic Maxwell terms.

摘要翻译： 调整快速自旋回波脉冲序列以减少或消除由线性成像梯度引起的麦克斯韦术引起的图像伪像。 切片选择，相位编码和读出梯度的波形在形状，大小或位置上进行调整，以消除或减少由空间二次Maxwell项引起的相位误差。

公开(公告)号：US5689186A

公开(公告)日：1997-11-18

申请号：US577000

申请日：1995-12-26

申请人： Joseph Kenneth Maier ,  Frederick Howard Epstein ,  Xiaohong Zhou ,  Lawrence Edward Ploetz ,  Paul E. Licato

发明人： Joseph Kenneth Maier ,  Frederick Howard Epstein ,  Xiaohong Zhou ,  Lawrence Edward Ploetz ,  Paul E. Licato

IPC分类号： G01R33/54 ,  G01V3/00

CPC分类号： G01R33/4833

摘要： An off-center NMR image is produced using an EPI pulse sequence. The offset along the readout gradient axis is achieved by shifting the frequency of an RF reference signal used to demodulate the received NMR echo signals. Phase errors produced by the NMR system and by the shifts in reference signal frequency are corrected in "real time" by also shifting the phase of the RF reference signal.

摘要翻译： 使用EPI脉冲序列产生偏心NMR图像。 沿读出梯度轴的偏移量通过移位用于解调所接收的NMR回波信号的RF参考信号的频率来实现。 由NMR系统产生的相位误差和参考信号频率的偏移通过也移动RF参考信号的相位而以“实时”校正。

公开(公告)号：US08781583B2

公开(公告)日：2014-07-15

申请号：US13353919

申请日：2012-01-19

申请人： Richard N. M. Cornelussen ,  Xiaohong Zhou ,  Robert Stadler ,  Lilian Kornet

发明人： Richard N. M. Cornelussen ,  Xiaohong Zhou ,  Robert Stadler ,  Lilian Kornet

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36585

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US08781582B2

公开(公告)日：2014-07-15

申请号：US13353802

申请日：2012-01-19

申请人： Paul D. Ziegler ,  Lilian Kornet ,  Xiaohong Zhou ,  Richard N. M. Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Paul D. Ziegler ,  Lilian Kornet ,  Xiaohong Zhou ,  Richard N. M. Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/37

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3702 ,  A61N1/37235 ,  A61N1/3962

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

公开(公告)号：US08620425B2

公开(公告)日：2013-12-31

申请号：US12848010

申请日：2010-07-30

申请人： Xiaohong Zhou ,  John Edward Burnes ,  Lilian Kornet ,  Richard N. M. Cornelussen

发明人： Xiaohong Zhou ,  John Edward Burnes ,  Lilian Kornet ,  Richard N. M. Cornelussen

IPC分类号： A61N1/05

CPC分类号： A61N1/36139 ,  A61B5/04001 ,  A61N1/36114 ,  A61N1/36514 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3962

摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.

摘要翻译： 神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。 神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。

公开(公告)号：US08452394B2

公开(公告)日：2013-05-28

申请号：US12362768

申请日：2009-01-30

申请人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  James D. Reinke ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  Timothy Davis

发明人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  James D. Reinke ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  Timothy Davis

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/3622 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/3962 ,  A61N2001/083

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US08437837B2

公开(公告)日：2013-05-07

申请号：US11536946

申请日：2006-09-29

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： A61B5/04 ,  A61N1/00

CPC分类号： A61B5/0456 ,  A61B5/0452 ,  A61N1/365 ,  G16H40/63

摘要： An implantable medical device and associated method assesses T-wave alternans. The method includes sensing a cardiac signal from implanted electrodes subsequent to a premature contraction; measuring a T-wave parameter from the sensed cardiac signal for a plurality of cardiac cycles; and determining a T-wave alternans metric corresponding to the measured T-wave parameter.

摘要翻译： 可植入医疗器械和相关方法评估T波交替。 该方法包括在过早收缩之后感测来自植入电极的心脏信号; 从感测的心脏信号中测量多个心动周期的T波参数; 以及确定对应于所测量的T波参数的T波交替量度。

公开(公告)号：US08396539B2

公开(公告)日：2013-03-12

申请号：US11676128

申请日：2007-02-16

申请人： Vinod Sharma ,  Xiaohong Zhou

发明人： Vinod Sharma ,  Xiaohong Zhou

IPC分类号： A61B5/04

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。