公开(公告)号：US08706223B2

公开(公告)日：2014-04-22

申请号：US13353891

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/04

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/368 ,  A61N1/37235

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

公开(公告)号：US08781582B2

公开(公告)日：2014-07-15

申请号：US13353802

申请日：2012-01-19

申请人： Paul D. Ziegler ,  Lilian Kornet ,  Xiaohong Zhou ,  Richard N. M. Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Paul D. Ziegler ,  Lilian Kornet ,  Xiaohong Zhou ,  Richard N. M. Cornelussen ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/37

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3702 ,  A61N1/37235 ,  A61N1/3962

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

公开(公告)号：US08725259B2

公开(公告)日：2014-05-13

申请号：US13353861

申请日：2012-01-19

申请人： Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Xiaohong Zhou ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Xiaohong Zhou ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US08718763B2

公开(公告)日：2014-05-06

申请号：US13353824

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Robert Stadler ,  Richard N. M. Cornelussen ,  Lilian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Robert Stadler ,  Richard N. M. Cornelussen ,  Lilian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US20120185010A1

公开(公告)日：2012-07-19

申请号：US13353891

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N.M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Lilian Kornet ,  Richard N.M. Cornelussen ,  Paul D. Ziegler ,  Robert Stadler ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/368 ,  A61N1/37235

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US20120185009A1

公开(公告)日：2012-07-19

申请号：US13353861

申请日：2012-01-19

申请人： Lilian Kornet ,  Richard N.M. Cornelussen ,  Paul D. Ziegler ,  Xiaohong Zhou ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Lilian Kornet ,  Richard N.M. Cornelussen ,  Paul D. Ziegler ,  Xiaohong Zhou ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US08781583B2

公开(公告)日：2014-07-15

申请号：US13353919

申请日：2012-01-19

申请人： Richard N. M. Cornelussen ,  Xiaohong Zhou ,  Robert Stadler ,  Lilian Kornet

发明人： Richard N. M. Cornelussen ,  Xiaohong Zhou ,  Robert Stadler ,  Lilian Kornet

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36585

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US08639327B2

公开(公告)日：2014-01-28

申请号：US12848019

申请日：2010-07-30

申请人： Xiaohong Zhou ,  John Edward Burnes ,  Lilian Kornet ,  Richard N. M. Cornelussen

发明人： Xiaohong Zhou ,  John Edward Burnes ,  Lilian Kornet ,  Richard N. M. Cornelussen

IPC分类号： A61N1/05

CPC分类号： A61N1/36139 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/36514 ,  A61N1/3937 ,  A61N1/3987

摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.

摘要翻译： 神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。 神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。

公开(公告)号：US08620425B2

公开(公告)日：2013-12-31

申请号：US12848010

申请日：2010-07-30

申请人： Xiaohong Zhou ,  John Edward Burnes ,  Lilian Kornet ,  Richard N. M. Cornelussen

发明人： Xiaohong Zhou ,  John Edward Burnes ,  Lilian Kornet ,  Richard N. M. Cornelussen

IPC分类号： A61N1/05

CPC分类号： A61N1/36139 ,  A61B5/04001 ,  A61N1/36114 ,  A61N1/36514 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3962

摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.

摘要翻译： 神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。 神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。

公开(公告)号：US09227069B2

公开(公告)日：2016-01-05

申请号：US13047928

申请日：2011-03-15

申请人： Vinayakrishnan Rajan ,  Richard N. M. Cornelussen ,  Berthold Stegemann ,  Lilian Kornet

发明人： Vinayakrishnan Rajan ,  Richard N. M. Cornelussen ,  Berthold Stegemann ,  Lilian Kornet

IPC分类号： A61N1/00 ,  A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： An implantable medical device senses atrial depolarizations having associated refractory periods thereafter and delivers electrical stimulation pulses during the associated refractory periods to stimulate the atrioventricular (AV) node to cause a prolonged conduction time of an atrial depolarization to a ventricular chamber. The device delivers a pacing pulse to a first ventricular chamber during the prolonged conduction time to cause a contraction and associated refractory period of the first ventricular chamber, the first ventricular chamber contraction occurring earlier than a contraction of a second ventricular chamber.

摘要翻译： 植入式医疗装置感测其后具有相关不应期的心房去极化，并且在相关联的不应期期间传递电刺激脉冲以刺激房室（AV）节点，从而导致心室去极化延长到心室的传导时间。 该设备在延长的传导时间期间将起搏脉冲递送到第一心室，以引起第一心室的收缩和相关联的不应期，第一心室的收缩早于第二心室的收缩。