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61 条记录 (耗时 0.068 秒)

    C-2 modified erythromycin derivatives
    41.
    发明授权
    C-2 modified erythromycin derivatives 有权
    C-2修饰红霉素衍生物

    公开(公告)号：US06355620B1

    公开(公告)日：2002-03-12

    申请号：US09312517

    申请日：1999-05-14

    申请人： Zhenkun Ma ,  Yat Sun Or ,  Ly Tam Phan ,  Suoming Zhang ,  Richard F. Clark

    发明人： Zhenkun Ma ,  Yat Sun Or ,  Ly Tam Phan ,  Suoming Zhang ,  Richard F. Clark

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： A compound having the formula selected from the group consisting of a compound of formula I a compound of formula II a compound of formula III as well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

    摘要翻译： 具有下式的化合物选自式Ia化合物式IIa化合物式III化合物及其药学上可接受的盐，酯，溶剂合物，代谢物和前药，可用于治疗细菌感染。 还提供了药学上可接受的组合物，治疗细菌感染的方法和化合物的制备方法。

    6,11-bridged biaryl macrolides
    43.
    发明授权
    6,11-bridged biaryl macrolides 有权
    6,11桥接的联芳基大环内酯类

    公开(公告)号：US08354383B2

    公开(公告)日：2013-01-15

    申请号：US12399801

    申请日：2009-03-06

    申请人： In Jong Kim ,  Tongzhu Liu ,  Jiang Long ,  Guoqiang Wang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： In Jong Kim ,  Tongzhu Liu ,  Jiang Long ,  Guoqiang Wang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07D493/08 ,  C07F9/65586 ,  C07H17/08

    摘要： The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II或X的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6,11-bicyclolides: bridged biaryl macrolide derivatives
    44.
    发明授权
    6,11-bicyclolides: bridged biaryl macrolide derivatives 有权
    6,11-双环氯化物：桥连联芳基大环内酯衍生物

    公开(公告)号：US08273720B2

    公开(公告)日：2012-09-25

    申请号：US12388333

    申请日：2009-02-18

    申请人： In Jong Kim ,  Tongzhu Liu ,  Heejin Kim ,  Yanchun Wang ,  Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    发明人： In Jong Kim ,  Tongzhu Liu ,  Heejin Kim ,  Yanchun Wang ,  Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    C-9 alkenylidine bridged macrolides
    47.
    发明授权
    C-9 alkenylidine bridged macrolides 有权
    C-9链烯基桥连大环内酯类

    公开(公告)号：US07622452B2

    公开(公告)日：2009-11-24

    申请号：US11940766

    申请日：2007-11-15

    申请人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07D493/08 ,  C07D498/18

    摘要： The present invention discloses compounds of formulae (I), (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了具有抗菌性能的式（I），（II）或其药学上可接受的盐，酯或前药的化合物。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    8A,11-BICYCLIC 8A-AZALIDE DERIVATIVES
    49.
    发明申请
    8A,11-BICYCLIC 8A-AZALIDE DERIVATIVES 审中-公开
    8A，11-BICYCLIC 8A-AZALIDE DERIVATIVES

    公开(公告)号：US20070259822A1

    公开(公告)日：2007-11-08

    申请号：US11742794

    申请日：2007-05-01

    申请人： Yat Sun Or ,  Ly Tam Phan ,  Guoqiang Wang

    发明人： Yat Sun Or ,  Ly Tam Phan ,  Guoqiang Wang

    IPC分类号： A61K31/7052 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9N-substituted 6-11 bicyclic erythromycin derivatives
    50.
    发明授权
    9N-substituted 6-11 bicyclic erythromycin derivatives 失效
    9N-取代的6-11双环红霉素衍生物

    公开(公告)号：US07265094B2

    公开(公告)日：2007-09-04

    申请号：US11031465

    申请日：2005-01-07

    申请人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋物，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。