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公开(公告)号：US20070244160A1
公开(公告)日：2007-10-18
申请号：US11758225
申请日：2007-06-05
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07064110B2
公开(公告)日：2006-06-20
申请号：US10717290
申请日：2003-11-19
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20090324577A1
公开(公告)日：2009-12-31
申请号：US12493847
申请日：2009-06-29
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/04
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07273853B2
公开(公告)日：2007-09-25
申请号：US11042720
申请日：2005-01-25
申请人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06878691B2
公开(公告)日：2005-04-12
申请号：US10429485
申请日：2003-05-05
申请人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20050159370A1
公开(公告)日：2005-07-21
申请号：US11042720
申请日：2005-01-25
申请人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
发明人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
IPC分类号： A61K31/7052 , A61K45/06 , C07H17/08
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
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公开(公告)号：US20050037982A1
公开(公告)日：2005-02-17
申请号：US10429485
申请日：2003-05-05
申请人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
发明人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
IPC分类号： C07H17/08 , A61K31/7048
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
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公开(公告)号：US07414030B2
公开(公告)日：2008-08-19
申请号：US11029640
申请日：2005-01-05
申请人： Nha Huu Vo , Guoqiang Wang , Guoyou Xu , Ying Hou , Ying Sun , Ly Tam Phan , Zhe Wang , Yat Sun Or
发明人： Nha Huu Vo , Guoqiang Wang , Guoyou Xu , Ying Hou , Ying Sun , Ly Tam Phan , Zhe Wang , Yat Sun Or
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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9.发明申请PROCESSES FOR THE PREPARATION OF 2 FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES 有权制备2 FLUORO 6-11双金属红霉素衍生物的方法公开(公告)号：US20090281293A1
公开(公告)日：2009-11-12
申请号：US12463140
申请日：2009-05-08
申请人： Guoyou Xu , Datong Tang , In Jong Kim , Ly Tam Phan , Yat Sun Or , Zhe Wang
发明人： Guoyou Xu , Datong Tang , In Jong Kim , Ly Tam Phan , Yat Sun Or , Zhe Wang
IPC分类号： C07H17/08 , C07D417/04
CPC分类号： C07D417/04 , C07D417/14 , C07D493/08
摘要： The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (X-c):
摘要翻译： 本发明涉及制备2-氟6-11双环红霉素衍生物的方法和中间体。 特别地，本发明涉及制备式（X-c）化合物的方法和中间体：
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10.发明授权Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives 有权制备2氟6-11双环红霉素衍生物的方法公开(公告)号：US08552162B2
公开(公告)日：2013-10-08
申请号：US12463140
申请日：2009-05-08
申请人： Guoyou Xu , Datong Tang , In Jong Kim , Ly Tam Phan , Yat Sun Or , Zhe Wang
发明人： Guoyou Xu , Datong Tang , In Jong Kim , Ly Tam Phan , Yat Sun Or , Zhe Wang
IPC分类号： C07H17/08
CPC分类号： C07D417/04 , C07D417/14 , C07D493/08
摘要： The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (X-c):
摘要翻译： 本发明涉及制备2-氟6-11双环红霉素衍生物的方法和中间体。 特别地，本发明涉及制备式（X-c）化合物的方法和中间体：
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