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15 条记录 (耗时 0.057 秒)

    6,11-bicyclic erythromycin derivatives
    7.
    发明授权
    6,11-bicyclic erythromycin derivatives 有权
    6,11-双环红霉素衍生物

    公开(公告)号：US07129221B2

    公开(公告)日：2006-10-31

    申请号：US10436622

    申请日：2003-05-13

    申请人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Yao-Ling Qiu ,  Nha Huu Vo ,  Jay Judson Farmer ,  Ying Hou

    发明人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Yao-Ling Qiu ,  Nha Huu Vo ,  Jay Judson Farmer ,  Ying Hou

    IPC分类号： A61K31/7048 ,  A61K31/7052 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11,12-substituted lactone ketolide derivatives having antibacterial activity
    8.
    发明授权
    11,12-substituted lactone ketolide derivatives having antibacterial activity 有权
    具有抗菌活性的11,12-取代内酯酮内酯衍生物

    公开(公告)号：US06727229B2

    公开(公告)日：2004-04-27

    申请号：US10223144

    申请日：2002-08-19

    申请人： Nha Huu Vo ,  Ly Tam Phan ,  Ying Hou ,  Tongzhu Liu ,  Yat Sun Or

    发明人： Nha Huu Vo ,  Ly Tam Phan ,  Ying Hou ,  Tongzhu Liu ,  Yat Sun Or

    IPC分类号： A01N4304

    CPC分类号： C07H17/08

    摘要： Novel 11-12 substituted lactone ketolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

    摘要翻译： 描述了新颖的11-12取代的内酯酮内酯衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。

    6-11 Bicyclic erythromycin derivatives
    9.
    发明授权
    6-11 Bicyclic erythromycin derivatives 失效
    6-11双环红霉素衍生物

    公开(公告)号：US07414030B2

    公开(公告)日：2008-08-19

    申请号：US11029640

    申请日：2005-01-05

    申请人： Nha Huu Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Tam Phan ,  Zhe Wang ,  Yat Sun Or

    发明人： Nha Huu Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Tam Phan ,  Zhe Wang ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    Anhydrolide derivatives having antibacterial activity
    10.
    发明授权
    Anhydrolide derivatives having antibacterial activity 失效
    具有抗菌活性的抗坏血酸衍生物

    公开(公告)号：US06720308B1

    公开(公告)日：2004-04-13

    申请号：US10289820

    申请日：2002-11-07

    申请人： Nha Huu Vo ,  Ying Hou ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Nha Huu Vo ,  Ying Hou ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A01N4304

    CPC分类号： A61K31/70 ,  C07H17/08

    摘要： Novel 11-12 substituted lactone anhydrolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

    摘要翻译： 描述了含有治疗有效量的本发明化合物与药学上可接受的载体的组合的新颖的11-12取代的内酯无水物衍生物和药学上可接受的组合物。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。