公开(公告)号：US09008777B2

公开(公告)日：2015-04-14

申请号：US13529226

申请日：2012-06-21

申请人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

发明人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

IPC分类号： A61N1/00 ,  A61N1/375 ,  A61N1/368

CPC分类号： A61N1/3756 ,  A61B5/042 ,  A61N1/362 ,  A61N1/368 ,  Y10T29/49002

摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.

摘要翻译： 无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。 端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。 非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。 第一电极从端盖的近端突出。 心脏内（IC）装置延伸部从电池盒的远端伸出。 该延伸部包括电连接到电池壳体的第二电极。 第二电极远离LIMD远端。 电子模块位于端盖的内部空腔内并与第一和第二电极连通。

公开(公告)号：US08700181B2

公开(公告)日：2014-04-15

申请号：US13352101

申请日：2012-01-17

申请人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

发明人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

IPC分类号： A61N1/362

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/3684 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) configured to be implanted entirely within a heart of a patient includes a housing configured to be securely attached to an interior wall portion of a chamber of the heart, and a stabilizing intra-cardiac (IC) device extension connected to the housing. The stabilizing IC device extension may include a stabilizer arm, and/or an appendage arm, or an elongated body or a loop member configured to be passively secured within the heart.

摘要翻译： 被配置为完全植入患者心脏的无引线心脏内心脏医疗装置（LIMD）包括被构造成可靠地附接到心脏室的内壁部分的壳体，以及稳定心脏内（IC） 设备扩展连接到外壳。 稳定IC装置延伸部可以包括稳定器臂和/或附肢臂，或者被配置为被动地固定在心脏内的细长主体或环形构件。

公开(公告)号：US08634912B2

公开(公告)日：2014-01-21

申请号：US13352136

申请日：2012-01-17

申请人： Gene A. Bornzin ,  Gabriel A. Mouchawar ,  Xiaoyi Min ,  John W. Poore ,  Edward Karst ,  Richard Samade ,  Zoltan Somogyi ,  Didier Theret

发明人： Gene A. Bornzin ,  Gabriel A. Mouchawar ,  Xiaoyi Min ,  John W. Poore ,  Edward Karst ,  Richard Samade ,  Zoltan Somogyi ,  Didier Theret

IPC分类号： A61N1/362

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N1/0573 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.

摘要翻译： 无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。 第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。 心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。 心脏内延伸部的稳定臂与相邻的腔室相接合。 心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

公开(公告)号：US20130296661A1

公开(公告)日：2013-11-07

申请号：US13464590

申请日：2012-05-04

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

IPC分类号： A61B5/0205 ,  A61B5/103 ,  A61B5/145 ,  A61B5/0215 ,  A61B5/0402

CPC分类号： A61B5/0205 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14532

摘要： An implantable physiologic sensor assembly is configured to be implanted within a patient. The assembly includes a module that houses an internal operative chamber, and a flexible pressure-detecting member connected to the module. The module and the pressure-detecting member are separated before implantation into the patient. At least a first end of the pressure-detecting member is configured to be inserted into an artery of the patient and a second end of the pressure-detecting member is connected to the module. The module is configured to be subcutaneously positioned within the patient.

摘要翻译： 可植入生理传感器组件被配置为植入患者体内。 组件包括容纳内部操作室的模块和连接到模块的柔性压力检测构件。 模块和压力检测构件在植入之前被分离到患者体内。 压力检测构件的至少第一端构造成插入到患者的动脉中，并且压力检测构件的第二端连接到模块。 该模块被配置为皮下置于患者体内。

公开(公告)号：US20130238056A1

公开(公告)日：2013-09-12

申请号：US13413560

申请日：2012-03-06

申请人： John W. Poore ,  Gene A. Bornzin

发明人： John W. Poore ,  Gene A. Bornzin

IPC分类号： A61N1/08

CPC分类号： A61N1/37276 ,  A61B5/0031 ,  A61B5/076 ,  A61B2560/0209

摘要： A communication circuit of an implantable device is coupled to a power source (e.g., including a battery) upon receipt of a radiofrequency (RF) signal at the implantable device. A circuit that controls whether the communication circuit is to be coupled to the power source obtains its power from the received RF signal. Thus, the implantable device is able to perform RF signal monitoring (e.g., RF “sniffing”) without using battery power. Battery power is then used for subsequent communication operations after it has been determined that the implantable device is receiving RF signals (e.g., from a verified external device).

摘要翻译： 在可植入装置接收到射频（RF）信号时，可植入装置的通信电路耦合到电源（例如，包括电池）。 控制通信电路是否耦合到电源的电路从接收的RF信号获得其功率。 因此，可植入装置能够在不使用电池电力的情况下执行RF信号监视（例如，RF“嗅探”）。 在确定可植入装置正在接收RF信号（例如，从已验证的外部装置）之后，将电池功率用于随后的通信操作。

公开(公告)号：US20130138006A1

公开(公告)日：2013-05-30

申请号：US13485534

申请日：2012-05-31

申请人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi

发明人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi

IPC分类号： A61B5/042

CPC分类号： A61B5/042 ,  A61B5/6869 ,  A61N1/368 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) includes multiple electrodes that allow for stimulation and sensing of the right ventricle (RV) and sensing of the right atrium (RA), even though it is entirely located in the RV. The LIMD includes a housing having a proximal end configured to engage local tissue in the local chamber and electrodes located at multiple locations along the housing. Sensing circuitry is configured to define a far field (FF) channel between a first combination of the electrodes to sense FF signals occurring in the adjacent chamber. The sensing circuitry is configured to define a near field (NF) channel between a second combination of the electrodes to sense NF signals occurring in the local chamber. A controller is configured to analyze the NF and FF signals to determine whether the NF and FF signals collectively indicate that a validated event of interest occurred in the adjacent chamber.

摘要翻译： 无引线心脏内心脏医疗器械（LIMD）包括多个电极，即使完全位于RV中，也能够对右心室（RV）进行刺激和感测，并检测右心房（RA）。 LIMD包括壳体，其具有被配置为接合局部室中的局部组织的近端和位于沿壳体的多个位置处的电极。 感测电路被配置为在电极的第一组合之间定义远场（FF）通道，以感测在相邻室中发生的FF信号。 感测电路被配置为在电极的第二组合之间限定近场（NF）通道，以感测在局部室中发生的NF信号。 控制器被配置为分析NF和FF信号以确定NF和FF信号是否共同表示在邻近室中发生了有效的感兴趣事件。

公开(公告)号：US20130110219A1

公开(公告)日：2013-05-02

申请号：US13352167

申请日：2012-01-17

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

IPC分类号： A61N1/05

CPC分类号： A61N1/059 ,  A61B17/3468 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3962

摘要： An assembly for introducing a leadless intra-cardiac medical device includes a sheath having an internal passage, wherein the sheath is configured to be maneuvered into the heart of the patient. A housing may be retained within the internal passage, wherein the housing is configured to be pushed out of the sheath, the housing having a first anchoring member configured to anchor the housing to a first implant location within the heart. The assembly may also include an electrode trailing the housing within the internal passage, wherein the electrode is also configured to be pushed out of the sheath. The electrode has a second anchoring member configured to anchor the electrode to a second implant location within the heart. A conductive wire connects the housing to the electrode, wherein movement of the housing out of the sheath causes the electrode to follow the movement to a distal end of the sheath.

摘要翻译： 用于引入无引线心脏内心脏医疗装置的组件包括具有内部通道的护套，其中护套构造成被操纵到患者的心脏中。 壳体可以被保持在内部通道内，其中壳体构造成被推出护套，壳体具有构造成将壳体锚定到心脏内的第一植入位置的第一锚定构件。 该组件还可以包括在内部通道内拖曳壳体的电极，其中电极还构造成被推出护套。 电极具有被配置为将电极锚定到心脏内的第二植入位置的第二锚定构件。 导电线将壳体连接到电极，其中壳体从鞘的移动导致电极跟随到鞘的远端的运动。

公开(公告)号：US20100114236A1

公开(公告)日：2010-05-06

申请号：US12263348

申请日：2008-10-31

申请人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore

发明人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore

IPC分类号： A61N1/362 ,  H01M10/36

CPC分类号： A61N1/378 ,  A61N1/3956 ,  A61N1/3981 ,  H01M8/16 ,  H01M10/0525 ,  H01M10/425 ,  H01M10/44 ,  H01M16/006 ,  H02J7/0054 ,  H02J7/0063 ,  Y02E60/527

摘要： A system and method for powering an implantable cardiac therapy device (ICTD) via a hybrid battery system. The hybrid battery is comprised of a low voltage and low current bioelectric cell, a high voltage and high current rechargeable cell, and a charging means. Via the charging means, the bioelectric cell maintains the rechargeable cell at or near full power. The rechargeable cell is configured to power some or all operations of the ICTD. Some ICTD operations may be powered directly by the bioelectric cell. The rechargeable cell is further configured to be charged via a continuous charging process, reducing the complexity of the charging circuitry. In an embodiment, at least the bioelectric cell is external to the ICTD, enabling easy replacement of this power source. In an embodiment, a consumable anode of the bioelectric cell is external to the ICTD, enabling replacement of the power source by replacing only the anode.

摘要翻译： 通过混合电池系统为植入式心脏治疗装置（ICTD）供电的系统和方法。 混合电池包括低电压和低电流生物电池，高电压和高电流可再充电电池以及充电装置。 通过充电装置，生物电池将可再充电电池维持在或接近全功率。 可充电电池被配置为为ICTD的一些或所有操作供电。 一些ICTD操作可以由生物电池直接供电。 可再充电电池还被配置为经由连续充电过程进行充电，从而降低充电电路的复杂性。 在一个实施例中，至少生物电池在ICTD的外部，使得能够容易地更换该电源。 在一个实施例中，生物电池的消耗性阳极在ICTD的外部，能够通过仅替换阳极来替换电源。

公开(公告)号：US06804556B1

公开(公告)日：2004-10-12

申请号：US10036026

申请日：2001-12-21

申请人： Joseph J. Florio ,  Gene A. Bornzin ,  John W. Poore ,  Douglas T. Kurschinski

发明人： Joseph J. Florio ,  Gene A. Bornzin ,  John W. Poore ,  Douglas T. Kurschinski

IPC分类号： A61N1365

CPC分类号： A61N1/368

摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.

摘要翻译： 描述了使用起搏器超速起搏心脏的技术，其中在确定的搜索周期内检测到至少两个固有节拍时，超速起搏速率仅增加。 在一种特定技术中，只有在X个心动周期内检测到两个P波时，起搏速率才会增加。 在另一个具体技术中，只有在N个心动周期的块内检测到至少两个P波时，才能增加超速起搏速率。 在两种技术中，如果在最后Z个心动周期中没有发生增加，则超速起搏速率将降低。 通过仅在确定的心跳周期内响应于至少两个P波的检测来增加超速起搏速率，避免了过高的超速起搏速率。 描述了用于自适应地调节过驱动起搏参数的其它技术，以便实现例如95％起搏节拍的确定的目标起搏程度。 通过自适应地调整过驱动参数以保持目标起搏程度，平均超速起搏速度最小化，同时仍然保持大量的起搏节奏，从而降低患者内出现快速性心律失常的风险。

公开(公告)号：US06766195B1

公开(公告)日：2004-07-20

申请号：US09686630

申请日：2000-10-10

申请人： Gene A. Bornzin ,  Peter Boileau ,  Joseph J. Florio ,  John W. Poore ,  Kelly H. McClure

发明人： Gene A. Bornzin ,  Peter Boileau ,  Joseph J. Florio ,  John W. Poore ,  Kelly H. McClure

IPC分类号： A61N0118

CPC分类号： A61N1/3962 ,  A61N1/395

摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.

摘要翻译： 提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。 在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。 在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。 除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。 描述了方法和设备实施例。