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公开(公告)号：US20130034664A1
公开(公告)日：2013-02-07
申请号：US13568974
申请日：2012-08-07
摘要： The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.
摘要翻译： 本公开提供了用于包含释放聚合物的生物传感器的试剂组合物，制备这种生物传感器的方法和包含释放聚合物的试剂组合物的膜。 试剂组合物包含释放聚合物和有效分析物检测量酶，酶辅助因子和能够在生物传感器中起作用的氧化还原化合物作为（i）与工作电极相关联的氧化还原介体（ii）与 参比电极或（iii）与工作电极相关的氧化还原介体和用于参比电极的氧化还原对。
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公开(公告)号：US20100084268A1
公开(公告)日：2010-04-08
申请号：US12463210
申请日：2009-05-08
申请人： Robin D. Pierce , Shridhara Alva Karinka , Milind P. Nagale , Ross D. Meyer , W. James Scott , Gurdial Sanghera
发明人： Robin D. Pierce , Shridhara Alva Karinka , Milind P. Nagale , Ross D. Meyer , W. James Scott , Gurdial Sanghera
IPC分类号： G01N27/26
CPC分类号： C12Q1/004
摘要： A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode itself. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode. Alternatively, the biosensor can have a mediator or an enzyme or both incorporated into the conductive track leading from the working electrode to an electrical contact associated with the working electrode. In another alternative, the biosensor can have a mediator or an enzyme or both incorporated into the electrical contact associated with the working electrode itself. Furthermore, the biosensor can have a mediator or an enzyme or both incorporated into at least two of the foregoing components of the biosensor.
摘要翻译： 生物传感器，其中至少一个试剂构成工作电极的一部分，从工作电极引导到与工作电极相关联的电接触的导电轨道，或与工作电极相关的电接触。 例如，生物传感器可以具有引入工作电极本身的介体或酶或两者。 其他试剂可直接分配在电极本身上，也可以通过用酶浸渍诸如网状物或膜的基质，然后将浸渍的网状物或膜放置在电极上。 或者，生物传感器可以具有引入到从工作电极引导到与工作电极相关联的电接触的导电轨道中的介体或酶或两者。 在另一个替代方案中，生物传感器可以具有介质或酶或两者结合到与工作电极本身相关联的电接触中。 此外，生物传感器可以具有引入到生物传感器的至少两个前述组分中的介体或酶或两者。
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公开(公告)号：US07501053B2
公开(公告)日：2009-03-10
申请号：US10278657
申请日：2002-10-23
IPC分类号： G01N27/327
摘要： A biosensor that utilizes a mediator, i.e., an isomer of phenanthroline quinone, 1,10-phenanthroline-5,6-dione, and a metal ion, such as manganese, with an enzyme dependent upon NAD(P)+, such as, for example, glucose dehydrogenase, for improving the hematocrit bias and oxygen bias of biosensors. The electrodes of the biosensors employing this mediator and a metal ion provide an accurate clinical response over a hematocrit range that ranges from about 20% to about 70% and over an oxygen tension range that ranges from about 1 kPa to about 20 kPa.
摘要翻译： 使用介体的生物传感器，即菲咯啉醌，1,10-菲咯啉-5,6-二酮和金属离子（如锰）的异构体与依赖于NAD（P）+的酶， 例如葡萄糖脱氢酶，用于改善生物传感器的血细胞比容偏差和氧偏压。 使用该介体的生物传感器的电极和金属离子在约20％至约70％的血细胞比容范围和超过约1kPa至约20kPa范围内的氧气压力范围内提供精确的临床响应。
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公开(公告)号：US20130001101A1
公开(公告)日：2013-01-03
申请号：US13437695
申请日：2012-04-02
IPC分类号： G01N27/327 , C07F15/04
摘要： The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
摘要翻译： 本发明提供了试剂组合物以及利用试剂组合物的分析物测量装置和方法。
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公开(公告)号：US20120296189A1
公开(公告)日：2012-11-22
申请号：US13458556
申请日：2012-04-27
申请人： John Bhogal , Shridhara Alva Karinka , Timothy P. Henning , David Cunningham , Udo Hoss , Andrew H. Naegeli , John LaTour
发明人： John Bhogal , Shridhara Alva Karinka , Timothy P. Henning , David Cunningham , Udo Hoss , Andrew H. Naegeli , John LaTour
CPC分类号： A61B10/0045 , A61B5/14503 , A61B5/14514 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B2010/008 , G01N30/96
摘要： Provided are methods of measuring analyte concentrations in interstitial fluid samples, methods of determining accuracy of subcutaneously implantable analyte sensors, methods of manufacturing and determining calibration factors for subcutaneously implantable analyte sensors, as well as subcutaneously implantable analyte sensors manufactured according to the described methods and having a high level of accuracy. Methods of determining the concentration of an analyte in a bodily sample, and methods of extracting interstitial fluid are also provided.
摘要翻译： 提供了测量间质液样品中分析物浓度的方法，确定皮下可植入分析物传感器的准确性的方法，制备和确定皮下可植入分析物传感器的校准因子的方法，以及根据所述方法制造的皮下可植入分析物传感器，并具有 高精度。 还提供了确定身体样品中分析物浓度的方法和提取组织液的方法。
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公开(公告)号：US08262874B2
公开(公告)日：2012-09-11
申请号：US12102374
申请日：2008-04-14
摘要： The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.
摘要翻译： 本公开提供了用于包含释放聚合物的生物传感器的试剂组合物，制备这种生物传感器的方法和包含释放聚合物的试剂组合物的膜。 试剂组合物包含释放聚合物和有效分析物检测量酶，酶辅助因子和能够在生物传感器中起作用的氧化还原化合物作为（i）与工作电极相关联的氧化还原介体（ii）与 参比电极或（iii）与工作电极相关的氧化还原介体和用于参比电极的氧化还原对。
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公开(公告)号：US20080230384A1
公开(公告)日：2008-09-25
申请号：US11849803
申请日：2007-09-04
申请人： Robin D. Pierce , Shridhara Alva Karinka , Milind P. Nagale , Ross D. Meyer , W. James Scott , Gurdial Sanghera
发明人： Robin D. Pierce , Shridhara Alva Karinka , Milind P. Nagale , Ross D. Meyer , W. James Scott , Gurdial Sanghera
IPC分类号： G01N27/26
CPC分类号： C12Q1/004
摘要： A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode, into the conductive track leading from the working electrode to an electrical contact associated with the working electrode, and/or into the electrical contact associated with the working electrode. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode.
摘要翻译： 一种生物传感器，其中至少一个试剂构成工作电极的一部分，从工作电极引导到与工作电极相关联的电接触的导电轨道或与工作电极相关联的电接触。 例如，生物传感器可以具有引入到工作电极中的介体或酶或两者，并入到从工作电极引导到与工作电极相关联的电接触的导电轨道中，和/或与工作电极相关联的电接触 电极。 其他试剂可直接分配在电极本身上，也可以通过用酶浸渍诸如网状物或膜的基质，然后将浸渍的网状物或膜放置在电极上。
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公开(公告)号：US07086277B2
公开(公告)日：2006-08-08
申请号：US10784764
申请日：2004-02-23
CPC分类号： C12Q1/004
摘要： A device having a flow channel, wherein a layer of mesh is adhered to a surface forming a wall of a flow channel, but the layer of mesh is of such dimensions that the layer of mesh does not contact those portions of the device where electrochemical reactions occur and electrons flow. In one aspect, the invention provides a sensor, such as, for example, a biosensor, in the form of a strip, the sensor being suitable for electrochemical or optical measurement. The sensor comprises a base layer and a cover layer having a layer of mesh adhered thereto, and the base layer is separated from the cover layer by a spacer layer. The base layer, the cover layer having a layer of mesh adhered thereto, and the spacer layer define a flow channel into which a liquid sample is drawn therein and flows therethrough by means of wicking.
摘要翻译： 具有流动通道的装置，其中一层网状物粘附到形成流动通道的壁的表面上，但是网状物层的尺寸使得该网状物层不接触电化学反应的装置的那些部分 发生和电子流动。 在一个方面，本发明提供一种传感器，例如带状的传感器，例如生物传感器，该传感器适用于电化学或光学测量。 传感器包括基层和覆盖层，其具有粘附到其上的网的层，并且基底层通过间隔层与覆盖层分离。 基层，覆盖层具有粘附到其上的网状层，间隔层限定了流体通道，液体样品被抽吸到其中并通过芯吸流过其中。
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公开(公告)号：US06863800B2
公开(公告)日：2005-03-08
申请号：US10062313
申请日：2002-02-01
IPC分类号： G01N27/327 , B01L3/00 , C12Q1/00 , G01N27/416 , G01N33/487 , G01N33/543
CPC分类号： C12Q1/002 , B01L3/5023 , G01N27/3272 , G01N33/5438
摘要： A biosensor in the form of a strip. In one embodiment, the biosensor strip comprises an electrode support, a first electrode, i.e., a working electrode, a second electrode, i.e., a counter electrode, and a third electrode, i.e., a reference electrode. Each of the electrodes is disposed on and supported by the electrode support. Each of the electrodes is spaced apart from the other two electrodes. The biosensor strip can include a covering layer, which defines an enclosed space over the electrodes. This enclosed space includes a zone where an analyte in the sample reacts with reagent(s) deposited at the working electrode. This zone is referred to as the reaction zone. The covering layer has an aperture for receiving a sample for introduction into the reaction zone. The biosensor strip can also include at least one layer of mesh interposed in the enclosed space between the covering layer and the electrodes in the reaction zone. This layer of mesh facilitates transporting of the sample to the electrodes in the reaction zone. In another embodiment, a biosensor strip can be constructed to provide a configuration that will allow the sample to be introduced to the reaction zone by action of capillary force. In this embodiment, the layer of mesh can be omitted. The invention also provides a method for determining the concentration of glucose in a sample of whole blood by using the biosensor of this invention.
摘要翻译： 一种带状生物传感器。 在一个实施例中，生物传感器条包括电极支架，第一电极，即工作电极，第二电极，即对电极和第三电极，即参考电极。 每个电极设置在电极支撑件上并由电极支撑件支撑。 每个电极与其他两个电极间隔开。 生物传感器条可以包括覆盖层，其限定电极上的封闭空间。 该封闭空间包括样品中分析物与沉积在工作电极上的试剂反应的区域。 该区称为反应区。 覆盖层具有用于接收用于引入反应区的样品的孔。 生物传感器条还可以包括至少一个介于覆盖层和反应区中的电极之间的封闭空间中的网格层。 该层网状物有利于将样品运送到反应区中的电极。 在另一个实施方案中，可以构造生物传感器条，以提供允许通过毛细管力的作用将样品引入反应区的构型。 在本实施例中，可以省略网格层。 本发明还提供了通过使用本发明的生物传感器来测定全血样品中葡萄糖浓度的方法。
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