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公开(公告)号：US20120301475A1
公开(公告)日：2012-11-29
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： C07K16/40 , G01N33/573 , G01N33/574 , A61N5/00 , A61K39/395 , A61P35/00 , A61P35/02 , C12N5/20 , C12Q1/70
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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42.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF FOR TREATMENT OF IMMUNE RELATED DISORDERS AND CANCER 有权多肽和多核苷酸及其用于治疗免疫相关疾病和癌症的用途公开(公告)号：US20140044641A1
公开(公告)日：2014-02-13
申请号：US14111767
申请日：2012-04-16
申请人： Amir Toporik , Amit Novik , Ronen Shemesh
发明人： Amir Toporik , Amit Novik , Ronen Shemesh
IPC分类号： C07K16/28 , G01N33/53 , A61K39/395
CPC分类号： C07K14/70503 , A61K38/00 , A61K38/1774 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K39/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C12N2760/10022 , C12N2760/16121 , C12N2770/32031 , G01N33/53 , G01N33/57484 , G01N33/577 , G01N2333/47 , Y02A50/412 , Y02A50/423
摘要： This invention relates to LY6G6F, VSIG10, TMEM25 and LSR proteins, which are suitable targets for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders, and drug development. This invention further relates to soluble LY6G6F, VSIG10, TMEM25 and LSR molecules, extracellular domains of LY6G6F, VSIG10, TMEM25 and LSR and conjugates, which are suitable drugs for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders. This invention further relates to antibodies and antigen binding fragments and conjugates containing same, and/or alternative scaffolds, specific for LY6G6F, VSIG10, TMEM25 or LSR molecules, which are suitable drugs for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders.
摘要翻译： 本发明涉及LY6G6F，VSIG10，TMEM25和LSR蛋白，其是免疫治疗，癌症治疗，感染性疾病和/或免疫相关病症以及药物开发的合适靶标。 本发明还涉及可溶性LY6G6F，VSIG10，TMEM25和LSR分子，LY6G6F，VSIG10，TMEM25和LSR的细胞外结构域和缀合物，其是用于免疫治疗，治疗癌症，感染性疾病和/或免疫相关疾病的合适的药物。 本发明还涉及对于LY6G6F，VSIG10，TMEM25或LSR分子具有特异性的抗体和抗原结合片段和含有其的缀合物和/或替代性支架，其是用于免疫治疗，癌症治疗，感染性疾病和/或免疫的合适的药物 相关疾病。
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43.发明授权Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer 有权多肽和多核苷酸，及其用于治疗免疫相关疾病和癌症的用途公开(公告)号：US09409987B2
公开(公告)日：2016-08-09
申请号：US14111767
申请日：2012-04-16
申请人： Amir Toporik , Amit Novik , Ronen Shemesh
发明人： Amir Toporik , Amit Novik , Ronen Shemesh
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00 , A61K39/39 , C07K14/705 , C07K16/18 , G01N33/53
CPC分类号： C07K14/70503 , A61K38/00 , A61K38/1774 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K39/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C12N2760/10022 , C12N2760/16121 , C12N2770/32031 , G01N33/53 , G01N33/57484 , G01N33/577 , G01N2333/47 , Y02A50/412 , Y02A50/423
摘要： This invention relates to LY6G6F, VSIG10, TMEM25 and LSR proteins, which are suitable targets for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders, and drug development. This invention further relates to soluble LY6G6F, VSIG10, TMEM25 and LSR molecules, extracellular domains of LY6G6F, VSIG10, TMEM25 and LSR and conjugates, which are suitable drugs for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders. This invention further relates to antibodies and antigen binding fragments and conjugates containing same, and/or alternative scaffolds, specific for LY6G6F, VSIG10, TMEM25 or LSR molecules, which are suitable drugs for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders.
摘要翻译： 本发明涉及LY6G6F，VSIG10，TMEM25和LSR蛋白，其是免疫治疗，癌症治疗，感染性疾病和/或免疫相关病症以及药物开发的合适靶标。 本发明还涉及可溶性LY6G6F，VSIG10，TMEM25和LSR分子，LY6G6F，VSIG10，TMEM25和LSR的细胞外结构域和缀合物，其是用于免疫治疗，治疗癌症，感染性疾病和/或免疫相关疾病的合适的药物。 本发明还涉及对于LY6G6F，VSIG10，TMEM25或LSR分子具有特异性的抗体和抗原结合片段和含有其的缀合物和/或替代性支架，其是用于免疫治疗，癌症治疗，感染性疾病和/或免疫的合适的药物 相关疾病。
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公开(公告)号：US20100184839A1
公开(公告)日：2010-07-22
申请号：US12598286
申请日：2008-04-30
申请人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
发明人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
IPC分类号： A61K31/7088 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The invention relates to the identification of allelic polymorphism in a diabetes associated gene, particularly in a gene encoding phosphofructokinase (PFK) and use thereof for diagnosing diabetes predisposition and state and for predicting the response to a therapeutic agent.
摘要翻译： 本发明涉及鉴定糖尿病相关基因中的等位基因多态性，特别是在编码磷酸果糖激酶（PFK）的基因中的等位基因多态性及其用于诊断糖尿病倾向和状态以及预测对治疗剂的应答的用途。
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45.发明授权Variants of human glycoprotein hormone alpha chain: compositions and uses thereof 失效人类糖蛋白激素α链的变体：其组成及用途公开(公告)号：US07655781B2
公开(公告)日：2010-02-02
申请号：US11429553
申请日：2006-05-05
申请人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary , Gil Shalev , Gideon Baum , Yoseph Shaaltiel
发明人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary , Gil Shalev , Gideon Baum , Yoseph Shaaltiel
摘要： The present invention provides human glycoprotein hormone (hGPH) α-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
摘要翻译： 本发明提供人糖蛋白激素（hGPH）α链剪接变体，包括编码这些变体的分离的核酸和编码的氨基酸序列，以及包含这些序列的抗体，反义寡核苷酸，表达载体和宿主细胞。 本发明还公开了这些序列用于诊断，预防和治疗与糖蛋白激素相关的症状，疾病和病症的用途。
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46.发明申请Variants of human glycoprotein hormone alpha chain: compositions and uses thereof 审中-公开人类糖蛋白激素α链的变体：其组成及用途公开(公告)号：US20050158740A1
公开(公告)日：2005-07-21
申请号：US10984379
申请日：2004-11-08
申请人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary
发明人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary
摘要： The present invention provides human glycoprotein hormone (hGPH) α-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
摘要翻译： 本发明提供人糖蛋白激素（hGPH）α链剪接变体，包括编码这些变体的分离的核酸和编码的氨基酸序列，以及包含这些序列的抗体，反义寡核苷酸，表达载体和宿主细胞。 本发明还公开了这些序列用于诊断，预防和治疗与糖蛋白激素相关的症状，疾病和病症的用途。
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47.发明申请Variants of interleukin-1 receptor antagonist: compositions and uses thereof 审中-公开白细胞介素-1受体拮抗剂的变体：组合物及其用途公开(公告)号：US20050159590A1
公开(公告)日：2005-07-21
申请号：US10926773
申请日：2004-08-25
申请人： Galit Rotman , Dalit Milo-Landesman , Dvir Dahary , Ronen Shemesh , Jeanne Bernstein , Dani Eshel
发明人： Galit Rotman , Dalit Milo-Landesman , Dvir Dahary , Ronen Shemesh , Jeanne Bernstein , Dani Eshel
CPC分类号： C07K14/54
摘要： The present invention provides Interleukin-1 receptor antagonist splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells that include these sequences. The present invention further discloses methods of using these sequences in the diagnosis, prognosis, treatment, and prevention of diseases and disorders mediated by Interleukin-1.
摘要翻译： 本发明提供白细胞介素-1受体拮抗剂剪接变体，包括编码这些变体的分离的核酸和编码的氨基酸序列，以及包括这些序列的抗体，反义寡核苷酸，表达载体和宿主细胞。 本发明还公开了使用这些序列在由白细胞介素-1介导的疾病和病症的诊断，预后，治疗和预防中的方法。
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48.发明申请Variants of human glycoprotein hormone alpha chain: compositions and uses thereof 失效人类糖蛋白激素α链的变体：其组成及用途公开(公告)号：US20070298463A1
公开(公告)日：2007-12-27
申请号：US11429553
申请日：2006-05-05
申请人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary , Gil Shalev , Gideon Baum , Yoseph Shaaltiel
发明人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary , Gil Shalev , Gideon Baum , Yoseph Shaaltiel
摘要： The present invention provides human glycoprotein hormone (hGPH) α-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
摘要翻译： 本发明提供人糖蛋白激素（hGPH）α链剪接变体，包括编码这些变体的分离的核酸和编码的氨基酸序列，以及包含这些序列的抗体，反义寡核苷酸，表达载体和宿主细胞。 本发明还公开了这些序列用于诊断，预防和治疗与糖蛋白激素相关的症状，疾病和病症的用途。
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公开(公告)号：US20140056811A1
公开(公告)日：2014-02-27
申请号：US13976502
申请日：2011-12-26
申请人： Etai Jacob , Amir Toporik , Ronen Shemesh , Ofer Levy
发明人： Etai Jacob , Amir Toporik , Ronen Shemesh , Ofer Levy
IPC分类号： A61K47/48
CPC分类号： C07K14/78 , A61K47/62 , C07K14/47 , C07K2319/01
摘要： The present invention is related to peptides, which are suitable for use as cell-penetrating peptides (CPPs), variants thereof and/or complexes, fusion molecules and/or conjugates comprising same, use thereof for manufacture of compositions for diagnosing, treating and/or preventing of medical conditions.
摘要翻译： 本发明涉及适合用作细胞穿透肽（CPP），其变体和/或复合物，包含其的融合分子和/或缀合物的肽，其用于制备用于诊断，治疗和/ 或预防医疗状况。
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50.发明申请Splice variants of peptide YY, neuropeptide Y, pancreatic peptide Y and Amylin, and uses thereof 审中-公开肽YY，神经肽Y，胰肽Y和胰岛淀粉样多肽的剪接变体及其用途公开(公告)号：US20060052301A1
公开(公告)日：2006-03-09
申请号：US11145463
申请日：2005-06-02
申请人： Ronen Shemesh , Yossef Kliger , Lewis Neville , Jeanne Bernstein , Dani Eshel
发明人： Ronen Shemesh , Yossef Kliger , Lewis Neville , Jeanne Bernstein , Dani Eshel
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K14/57545 , C07K16/26 , C07K2319/00
摘要： The present invention relates to alternative splice variants of Amylin and members of the Pancreatic Polypeptide family, namely PYY, NPY, and PPY, vectors and compositions that include the same, and methods of use thereof. This invention provides peptides, nucleic acid sequences which encode same, analogs and derivatives thereof, antibodies which specifically recognize the variant sequences, compositions that include the same and methods of use thereof.
摘要翻译： 本发明涉及胰岛淀粉样多肽的选择性剪接变体和胰腺多肽家族的成员，即PYY，NPY和PPY，包含其的载体和组合物及其使用方法。 本发明提供肽，其编码相同的核酸序列，其类似物和衍生物，特异性识别变体序列的抗体，包括其的组合物及其使用方法。
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