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    Chimeric lyssavirus nucleic acids and polypeptides
    3.
    发明授权
    Chimeric lyssavirus nucleic acids and polypeptides 失效
    嵌合式淋巴细胞病毒核酸和多肽

    公开(公告)号：US07235245B2

    公开(公告)日：2007-06-26

    申请号：US10608538

    申请日：2003-06-30

    申请人： Yves Jacob ,  Pierre Perrin ,  Noël Tordo ,  Chokri Bahloul

    发明人： Yves Jacob ,  Pierre Perrin ,  Noël Tordo ,  Chokri Bahloul

    IPC分类号： A61K39/205 ,  A61K39/295 ,  C12N15/47

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/13 ,  A61K39/205 ,  A61K2039/53 ,  C12N2760/10022 ,  C12N2760/10034 ,  C12N2760/20122 ,  C12N2760/20134 ,  C12N2770/32622 ,  C12N2770/32634 ,  Y02A50/412

    摘要： The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a lyssavirus glycoprotein, which has been found to improve the immunogenicity of lyssavirus epitopes for protection from rabies. The chimeric nucleic acids and proteins can also contain antigenic determinants for epitopes other than those of lyssavirus. Thus, the invention provides chimeric nucleic acids and polypeptides that elicit a strong immune response to multiple antigens. Use of the methods of the present invention permits DNA vaccination without the need to supply multiple antigens on separate DNA molecules.

    摘要翻译： 本发明提供编码嵌合免疫原性多肽的嵌合核酸，优选包含在表达载体上。 核酸至少编码淋巴细胞病毒糖蛋白的位点III，其已被发现改善了用于保护狂犬病免疫原性的免疫原性。 嵌合核酸和蛋白质还可以含有除了狂犬病毒以外的表位的抗原决定簇。 因此，本发明提供了引起对多种抗原的强免疫应答的嵌合核酸和多肽。 使用本发明的方法允许DNA接种，而不需要在分开的DNA分子上提供多种抗原。

    MELAN-A-CARRIER CONJUGATES
    8.
    发明申请
    MELAN-A-CARRIER CONJUGATES 审中-公开
    梅兰运输公司

    公开(公告)号：US20110097417A1

    公开(公告)日：2011-04-28

    申请号：US12463985

    申请日：2009-05-11

    申请人： Martin F. BACHMANN ,  Vania Manolova ,  Edwin Meijerink ,  Karl G. Proba ,  Katrin Schwarz

    发明人： Martin F. BACHMANN ,  Vania Manolova ,  Edwin Meijerink ,  Karl G. Proba ,  Katrin Schwarz

    IPC分类号： A61K9/14 ,  A61K39/12 ,  A61P37/04

    CPC分类号： A61K39/39 ,  A61K2039/5258 ,  A61K2039/55561 ,  A61K2039/6075 ,  A61K2039/62 ,  A61K2039/64 ,  C07K14/005 ,  C07K14/4748 ,  C12N2710/22022 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2760/10022 ,  Y02A50/467

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs), and particular peptides derived from MelanA linked thereto. Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含VLP的修饰病毒样颗粒（VLP），其可加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸，以及衍生自与其连接的MelanA的特定肽。 这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。 与VLP本身的免疫应答相似，对于任何偶联，融合或附着于VLP的MelanA肽类似物的免疫应答也相似地增强。 此外，针对MelanA肽类似物的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。