公开(公告)号：US11798164B2

公开(公告)日：2023-10-24

申请号：US18177560

申请日：2023-03-02

Applicant: ACUCELA INC.

Inventor： Stephan Wyder ,  Matthias Pfister ,  Cyril Stoller ,  Philip M. Buscemi

IPC: G06T7/00 ,  G06T7/11 ,  G06T3/00 ,  G06V10/82 ,  G06N3/08 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G06N3/08 ,  G06T3/00 ,  G06T7/11 ,  G16H30/40 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30041 ,  G06V10/82 ,  G06V2201/03

Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.

公开(公告)号：US11787791B2

公开(公告)日：2023-10-17

申请号：US17279382

申请日：2019-09-27

Applicant: ACUCELA INC.

Inventor： Mark W. Orme ,  Edison S. Zuniga ,  Vladimir A. Kuksa ,  Russell Stuart Craft ,  Eduardo Moreno Saveedra ,  Johannes Wilhelm Georg Meissner ,  Jacobus Antonius Joseph den Hartog ,  Albert Cornelis Dros

IPC: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US11777340B2

公开(公告)日：2023-10-03

申请号：US17904450

申请日：2021-02-19

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Patrizia Weber ,  Marco Burgener ,  Jonas Butscher ,  Praveenth Sanmugarajah ,  Hans Bernhard ,  Amitava Gupta

IPC: H02J50/10 ,  H02J50/40 ,  A45C11/00 ,  A45C15/00 ,  G02C7/04 ,  G02C11/00 ,  H02J7/00

CPC classification number: H02J50/10 ,  A45C11/005 ,  A45C15/00 ,  G02C7/04 ,  G02C11/10 ,  H02J7/0013 ,  H02J7/0044 ,  H02J50/40

Abstract: A contact lens charging case comprises a container sized and shaped to receive an electronic contact lens (“eCL”) and charging coil to couple to a coil of the eCL. In some embodiments, the charging coil comprises a diameter larger than a diameter of the coil of the eCL, so as to decrease sensitivity of the location and orientation of the eCL in the container and improve coupling between the coils. In some embodiments, the charging coil is dimensioned so as to extend at least partially around the container that receives the eCL.

公开(公告)号：US20230284897A1

公开(公告)日：2023-09-14

申请号：US18005888

申请日：2021-09-30

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI

IPC: A61B3/103 ,  A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  A61B3/135

CPC classification number: A61B3/103 ,  A61B3/14 ,  A61B3/0025 ,  A61B3/1015 ,  A61B3/135 ,  A61B3/102

Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.

公开(公告)号：US11730363B2

公开(公告)日：2023-08-22

申请号：US17757748

申请日：2020-09-02

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B3/0075 ,  A61B3/0091 ,  A61B3/1005 ,  A61B3/12

Abstract: Improved optical coherence tomography systems and methods to measure retinal data are presented. The systems may be compact, provide in-home monitoring, and have automation to allow the patient to measure himself or herself.

公开(公告)号：US20230206440A1

公开(公告)日：2023-06-29

申请号：US18177560

申请日：2023-03-02

Applicant: ACUCELA INC.

Inventor： Stephan WYDER ,  Matthias PFISTER ,  Cyril STOLLER ,  Philip M. BUSCEMI

IPC: G06T7/00 ,  G06T7/11 ,  G06T3/00 ,  G06N3/08 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G06T7/11 ,  G06T3/00 ,  G06N3/08 ,  G16H30/40 ,  G06T2207/20084 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2207/20081 ,  G06V2201/03 ,  G06V10/82

Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.

公开(公告)号：US20230204980A1

公开(公告)日：2023-06-29

申请号：US18175648

申请日：2023-02-28

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Pascal LOSER ,  Ben CROOK ,  Massimo PINAZZA ,  Jim NIEBANCK ,  James PHILLIPS ,  Stefan BAUER

IPC: G02C7/08 ,  G02C5/14 ,  G02C11/00

CPC classification number: G02C7/083 ,  G02C5/146 ,  G02C11/10 ,  G02C2200/08

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US20230168521A1

公开(公告)日：2023-06-01

申请号：US18160200

申请日：2023-01-26

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noel FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

CPC classification number: G02C7/04 ,  G02C7/14 ,  G02C11/04 ,  G02C2202/24

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US20230118068A1

公开(公告)日：2023-04-20

申请号：US18067552

申请日：2022-12-16

Applicant: ACUCELA INC.

Inventor： Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/02 ,  G02C7/04 ,  G02C11/04 ,  G02C11/00

Abstract: A contact lens configured to decrease dark adaptation comprises one or more LEDs and directs light from the LED away from the fovea and toward the parafovea or perifoveal regions of the retina. In some embodiments, soft contact lens embedded with one or more arrays of microLEDs and electronics operating the LEDs is configured to be worn at night in order to inhibit dark adaptation and reduce oxygen consumption by the rods. The contact lens may be made of a single layer of a contact lens material or multiple layers sandwiching a flexible transparent plastic layer comprising the electronics and the LED arrays. The contact lens may be made of a hydrophilic hydrogel material that is biocompatible to the human cornea, or a silicone hydrogel material. The contact lens may be spherical and may provide refractive correction to the eye of the wearer.

公开(公告)号：US20230026567A1

公开(公告)日：2023-01-26

申请号：US17936082

申请日：2022-09-28

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI ,  Ryo KUBOTA

IPC: A61N5/06

Abstract: A stimulus is configured to treat astigmatism with changes in retinal thickness, independently of, or in combination with, treatment for myopia. In some embodiments, a stimulus pattern is arranged with respect to an astigmatic axis of the eye to decrease ocular growth in relation to the astigmatic axis. In some embodiments, the apparatus is configured to direct light to regions of retina outside the macula in relation to the astigmatic axis of the eye. In some embodiments, the intensity is modulated to provide the effect. A lens, such as a contact lens or spectacle lens may be configured with a plurality of light sources, such as projection units having a light source and focusing optics that work together to project anteriorly or posteriorly defocused images onto the retina at locations eccentric to the fovea.