公开(公告)号：US09918790B2

公开(公告)日：2018-03-20

申请号：US14604400

申请日：2015-01-23

Applicant: Old Dominion University Research Foundation

Inventor： Christian W. Zemlin

IPC: A61B18/14 ,  A61B18/00

CPC classification number: A61B18/1492 ,  A61B18/1477 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/00613

Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.

公开(公告)号：US09872721B2

公开(公告)日：2018-01-23

申请号：US13822010

申请日：2011-09-09

Applicant: Karl Schoenbach ,  Richard Heller

Inventor： Karl Schoenbach ,  Richard Heller

IPC: A61B18/12 ,  A61B18/14 ,  A61B18/00

CPC classification number: A61B18/14 ,  A61B18/1206 ,  A61B2018/0016 ,  A61B2018/124 ,  A61B2018/143 ,  A61B2018/1467

Abstract: Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.

公开(公告)号：US09173584B2

公开(公告)日：2015-11-03

申请号：US12809007

申请日：2008-12-19

Applicant: Karl H. Schoenbach ,  Shu Xiao

Inventor： Karl H. Schoenbach ,  Shu Xiao

IPC: A61B5/05 ,  A61B6/03

CPC classification number: A61B5/0507 ,  A61B5/05 ,  A61B6/03 ,  A61B2576/00

Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.

Abstract translation: 提供成像和记录系统。 该系统包括用于照射生物组织的大功率聚焦天线。 该系统还包括用于为天线供电的电源。 该系统还包括数据采集模块，用于记录由大功率聚焦天线照射的组织的介电特性。 系统使用超短电脉冲照射组织。

公开(公告)号：US08948878B2

公开(公告)日：2015-02-03

申请号：US13161362

申请日：2011-06-15

Applicant: Karl H. Schoenbach ,  Lesley Greene

Inventor： Karl H. Schoenbach ,  Lesley Greene

IPC: A61N1/00 ,  A61N1/20 ,  A61N1/32 ,  A61B18/12 ,  A61B18/14 ,  A61B18/00

CPC classification number: A61B18/12 ,  A61B18/1492 ,  A61B2018/00446 ,  A61N1/205 ,  A61N1/327

Abstract: A method and device for treating a condition aggravated by the presence of amyloid fibrils is disclosed. The method includes applying a plurality of ultra-short pulses to target tissue comprising amyloid fibrils. The plurality of ultra-short pulses produce an electric field in the target tissue sufficient to change a molecular structure of the amyloid fibrils without causing the death, destruction, or serious injury of healthy cells surrounding the target tissue. For example, the plurality of ultra-short pulses can be sufficient to change the molecular structure of amyloid fibrils without causing apoptosis or necrosis of surrounding cells. The ultra-short pulses can be applied using an electrode device or a wideband antenna. The ultra-short pulses can have a duration ranging from 1 ps to 10 ns, an amplitude ranging from 100 V to 1 MV, and can apply an electrical field to the target tissue ranging from 1 kV/cm to 1 MV/cm.

Abstract translation: 公开了一种用于治疗由淀粉样蛋白原纤维存在而加重的病症的方法和装置。 该方法包括将多个超短脉冲应用于包含淀粉样蛋白原纤维的靶组织。 多个超短脉冲在目标组织中产生足以改变淀粉样蛋白原纤维的分子结构的电场，而不会导致靶组织周围的健康细胞的死亡，破坏或严重损伤。 例如，多个超短脉冲可以足以改变淀粉样蛋白原纤维的分子结构，而不引起周围细胞的凋亡或坏死。 可以使用电极装置或宽带天线来施加超短脉冲。 超短脉冲可以具有1ps至10ns的持续时间，振幅范围为100V至1MV，并且可以向1KV / cm至1MV / cm的目标组织施加电场。

公开(公告)号：US20140223981A1

公开(公告)日：2014-08-14

申请号：US14180816

申请日：2014-02-14

Applicant: Patrick G. Hatcher ,  John Joseph Moriarty

Inventor： Patrick G. Hatcher ,  John Joseph Moriarty

IPC: C05G3/00 ,  C05C9/02 ,  C05C9/00 ,  C05C11/00

CPC classification number: C05C11/00 ,  C05C3/00 ,  C05F5/006 ,  C05F11/00 ,  Y02A40/211 ,  C05C9/00 ,  C05F3/00

Abstract: Described herein are fertilizers for enhancing the carbon sequestration properties of soil. The fertilizers described herein include algae comprising algaenan. In one aspect, the fertilizer includes (a) one or more organic nitrogen sources, (b) one or more synthetic nitrogen sources, and (c) algae comprising algaenan. The fertilizers and fertilizer compositions release nitrogen at a predictable rate over time, which can enhance growth of plants that are fertile with the composition described herein.

Abstract translation: 本文描述的是用于增强土壤的碳固存性质的肥料。 本文所述的肥料包括藻类藻类。 一方面，肥料包括（a）一种或多种有机氮源，（b）一种或多种合成氮源，和（c）藻类，包含藻类。 肥料和肥料组合物以可预测的速率随时间释放氮气，这可以通过本文所述的组合物增强可育的植物的生长。

公开(公告)号：US08586807B2

公开(公告)日：2013-11-19

申请号：US13470649

申请日：2012-05-14

Applicant: Patrick G. Hatcher

Inventor： Patrick G. Hatcher

IPC: C07C1/20 ,  C07C4/22

CPC classification number: C08H8/00 ,  C10G1/02 ,  C10G1/047 ,  C10G2300/1014 ,  Y02P30/20

Abstract: Disclosed herein is the use of terrestrial plant materials (e.g., leaves and bark) that contain biopolymer materials to produce hydrocarbon-rich crude oils that can be refined further into hydrocarbon-based biofuels, via the hydrous pyrolysis method, which involves heating to subcritical temperatures and pressures in an aqueous medium. One can also isolate the aliphatic biopolymers and utilize them as feedstocks for production of the hydrocarbon-rich crude via hydrous pyrolysis.

Abstract translation: 本文公开了含有生物聚合物材料的陆生植物材料（例如，叶和树皮）的用途，以生产可通过含水热解法进一步精炼成烃类生物燃料的富烃原油，其涉及加热至亚临界温度 和水介质中的压力。 人们还可以分离脂族生物聚合物，并利用它们作为通过含水热解生产富含烃的原油的原料。

公开(公告)号：US20130260435A1

公开(公告)日：2013-10-03

申请号：US13994508

申请日：2011-12-13

Applicant: Olga Pakhomova ,  Andrei G. Pakhomov

Inventor： Olga Pakhomova ,  Andrei G. Pakhomov

IPC: C12N13/00

CPC classification number: C12N13/00 ,  A61N1/327

Abstract: Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

Abstract translation: 提供了增强细胞膜渗透性的方法。 一种方法包括在第一电极和第二电极之间设置电池并在第一电极和第二电极之间施加多个电脉冲。 在该方法中，多个电脉冲包括以大于约10s的间隔分开的至少两列脉冲。 此外，电脉冲的幅度被选择为大于约0.2kV / cm。

公开(公告)号：US08502108B2

公开(公告)日：2013-08-06

申请号：US12459806

申请日：2009-07-08

Applicant: Abdel-Aleam H Mohamed ,  Karl H. Schoenbach ,  Robert Chiavarini ,  Robert O. Price ,  Juergen Kolb

Inventor： Abdel-Aleam H Mohamed ,  Karl H. Schoenbach ,  Robert Chiavarini ,  Robert O. Price ,  Juergen Kolb

IPC: B23K10/00

CPC classification number: H05H1/48 ,  H05H2001/2412

Abstract: A microhollow cathode discharge assembly capable of generating a low temperature, atmospheric pressure plasma micro jet is disclosed. The microhollow assembly has two electrodes: an anode and a cathode separated by a dielectric. A microhollow gas passage is disposed through the three layers. In some embodiments, the passage is tapered such that the area at the first electrode is larger than the area at the second electrode. When a potential is placed across the electrodes and a gas is directed through the gas passage, then a low temperature micro plasma jet can be created at atmospheric pressure or above.

Abstract translation: 公开了能够产生低温大气压等离子体微射流的微气体阴极放电组件。 微孔组件具有两个电极：由电介质隔开的阳极和阴极。 微气体通道穿过三层。 在一些实施例中，通道是锥形的，使得第一电极处的面积大于第二电极处的面积。 当电极放置在电极上并且气体被引导通过气体通道时，则可以在大气压或更高压力下产生低温微等离子体射流。

公开(公告)号：US20130189345A1

公开(公告)日：2013-07-25

申请号：US13737565

申请日：2013-01-09

Applicant: Old Dominion University Research Foundation

Inventor： Helmut BAUMGART ,  Diefeng GU

IPC: A01N25/34 ,  A61F13/00

CPC classification number: A01N25/34 ,  A61F13/00 ,  A61F2013/0091 ,  A61K33/24 ,  A61K45/06 ,  A61L2/10 ,  A61L9/205 ,  A61L15/20 ,  A61L15/42 ,  A61L29/126 ,  A61L29/14 ,  A61L31/128 ,  A61L31/14 ,  A61L2202/16 ,  A61L2202/24 ,  A61L2209/12 ,  C23C16/405 ,  C23C16/45555 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/31678 ,  Y10T428/31971 ,  A61K2300/00

Abstract: A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO2, and the light may be UV or visible light. A variety of methods including ALD may be used to coat the first material.

Abstract translation: 公开了包括伤口护理系统，制造伤口护理系统的方法，杀菌剂以及使用这些系统来治疗伤口的方法的各种制品和系统。 伤口护理系统可以包括包含一种或多种纤维或多孔介质的第一材料。 一种或多种纤维或多孔介质可以涂覆有能够抑制细菌生长并杀死细菌以使伤口护理系统无菌的第二种材料，增加第一种材料的吸收性或在暴露于光时两者 。 第一种材料可以是棉花或任何合适的纤维材料，第二种材料可以是TiO 2，并且光可以是UV或可见光。 可以使用包括ALD的各种方法来涂覆第一材料。

公开(公告)号：US08455699B2

公开(公告)日：2013-06-04

申请号：US13569621

申请日：2012-08-08

Applicant: Patrick G. Hatcher ,  Zhanfei Liu ,  Elodie Salmon

Inventor： Patrick G. Hatcher ,  Zhanfei Liu ,  Elodie Salmon

IPC: C07C43/00

CPC classification number: C10L1/026 ,  C10G2300/1014 ,  C10G2300/4081 ,  C11C3/003 ,  Y02E50/13 ,  Y02P20/582 ,  Y02P30/20

Abstract: Disclosed are processes for producing glycerol-related products. One process for producing glycerol-related products comprises introducing glycerol and an alkylation reagent to a substantially oxygen free environment. Another process for producing glycerol-related products comprises introducing a glycerol and tetramethylammonium hydroxide to a substantially oxygen free environment.

Abstract translation: 公开了生产甘油相关产品的方法。 制备甘油相关产物的一个方法包括将甘油和烷基化试剂引入基本上无氧的环境中。 制备甘油相关产物的另一种方法包括将甘油和四甲基氢氧化铵引入到基本上无氧的环境中。