公开(公告)号：US20160199561A1

公开(公告)日：2016-07-14

申请号：US14593110

申请日：2015-01-09

申请人： Elwha LLC

发明人： Ralph G. Dacey, JR. ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61M1/36

CPC分类号： B01D67/0088 ,  A61M1/0088 ,  A61M1/1623 ,  A61M1/1631 ,  A61M2205/3334 ,  B01D69/12 ,  B01D2325/26

摘要： A device and methods are disclosed herein for fluid removal during wound treatment or for removal or dialysis of components from blood or tissue. A device is disclosed that includes a multilayer membrane including a plurality of layers; an electroactive polymer within each layer; and a controller operably connected to sequentially activate the electroactive polymer to alter one or more sizes of the plurality of the variably-sized pores within one or more layers of the multilayer membrane. A device is disclosed that includes a multilayer membrane including a plurality of layers; an actuator operably attached to the plurality of layers of the multilayer membrane; and a controller operably activating the actuator to alter a relative lateral position of the two or more layers of the multilayer membrane to align two or more of the plurality of pores within the plurality of layers of the multilayer membrane.

摘要翻译： 本文公开了一种装置和方法，用于在伤口处理期间流体移除或用于从血液或组织中去除或透析组分。 公开了一种包括多层膜的装置，包括多层; 每层内的电活性聚合物; 以及控制器，其可操作地连接以依次激活所述电活性聚合物以改变所述多层膜的一个或多个层内的所述多个可变尺寸孔中的一个或多个尺寸。 公开了一种包括多层膜的装置，包括多层; 可操作地连接到多层膜的多个层的致动器; 以及控制器，其可操作地启动所述致动器以改变所述多层膜的所述两层或更多层的相对横向位置，以使所述多层膜的所述多个层中的所述多个孔中的两个或更多个孔对准。

公开(公告)号：US20160144093A1

公开(公告)日：2016-05-26

申请号：US15012764

申请日：2016-02-01

申请人： DEKA Products Limited Partnership

发明人： Jason A. Demers ,  David W. McGill ,  Jacob W. Scarpaci ,  James D. Dale ,  Jesse T. Bodwell ,  Tien-Shoe Wang

IPC分类号： A61M1/28

CPC分类号： A61M1/16 ,  A61M1/14 ,  A61M1/1623 ,  A61M1/1629 ,  A61M1/1631 ,  A61M1/1694 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M1/288 ,  A61M5/16809 ,  A61M5/16813 ,  A61M5/16827 ,  A61M39/1011 ,  A61M39/105 ,  A61M39/20 ,  A61M39/28 ,  A61M39/281 ,  A61M2039/1066 ,  A61M2205/12 ,  A61M2205/121 ,  A61M2205/122 ,  A61M2205/123 ,  A61M2205/127 ,  A61M2205/128 ,  A61M2205/13 ,  A61M2205/14 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/36 ,  A61M2205/502 ,  A61M2209/08 ,  F04B43/02 ,  F04B43/08 ,  F04B43/086 ,  Y02A90/26

摘要： A medical treatment system, such as a peritoneal dialysis system, may include a control and other features to enhance patient comfort and ease of use. For example, a cycler device may include a heater bag receiving section and a lid mounted to cover and uncover the heater bag receiving section, potentially enabling faster heating of a dialysate. A user interface may be moveable to be received into the receiving section and covered by the lid, if desired. The system may detect anomalous conditions, such as tilting of a housing of the system, and automatically recover without terminating a treatment. The system may include noise reduction features, such as porting pneumatic outputs to a common chamber, and others. The system may also automatically detect any one of several different solution lines connected to the system, and control operation accordingly, e.g., to mix solutions provided by two or more lines and form a needed dialysate solution. A cassette control surface may be arranged to have one or more ports that can detect a presence of a liquid, e.g., to identify if a cassette is leaking or has otherwise been compromised.

摘要翻译： 诸如腹膜透析系统的医疗系统可以包括控制和其他特征，以增强患者的舒适性和易于使用。 例如，循环仪装置可以包括加热器袋接收部分和安装成盖住和揭开加热器袋接收部分的盖子，潜在地使透析液的加热更快。 如果需要，用户接口可以被移动以被接收到接收部分中并被盖子覆盖。 系统可以检测异常情况，例如系统的壳体的倾斜，并且自动恢复而不终止治疗。 该系统可以包括噪声降低特征，例如将气动输出端口连接到公共室等。 系统还可以自动检测连接到系统的若干不同解决方案线中的任何一个，并且相应地控制操作，例如混合由两条或更多条线提供的方案并形成所需的透析液。 盒控制表面可以被布置成具有可以检测液体存在的一个或多个端口，例如，以识别磁带盒是否泄漏或以其他方式被损坏。

公开(公告)号：US20160058932A1

公开(公告)日：2016-03-03

申请号：US14843944

申请日：2015-09-02

申请人： LOCKHEED MARTIN CORPORATION

发明人： John B. STETSON, JR. ,  Sarah SIMON ,  Jacob L. SWETT

IPC分类号： A61M1/16

CPC分类号： B01D63/082 ,  A61M1/1631 ,  B01D71/021 ,  B01D2319/025 ,  B01D2319/06

摘要： Perforated graphene and other perforated two-dimensional materials can be used in hemodialysis membranes and blood filtration membranes for selective removal of components from blood in vivo and ex vivo. The membranes are useful in hemodialysis and hemofiltration techniques to provide improved patient care. Hemodialysis systems can include a hemodialysis membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Hemofiltration systems can include one or more and preferably two or more blood filtration membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Methods for performing hemodialysis can involve exposing blood from a patient to a hemodialysis membrane formed from a perforated two-dimensional material. Ex vivo dialysis techniques can be performed similarly. Methods for filtration of blood can involve passing blood through one or more filter membranes or through a plurality of sequential filter membranes.

摘要翻译： 穿孔石墨烯和其他穿孔二维材料可用于血液透析膜和血液过滤膜，用于在体内和体外选择性地从血液中除去组分。 该膜可用于血液透析和血液滤过技术，以提供改善的患者护理。 血液透析系统可以包括由穿孔石墨烯形成的血液透析膜或者设置在多孔支撑结构上的另一穿孔二维材料。 血液滤过系统可以包括一个或多个，优选两个或更多个由穿孔的石墨烯形成的血液过滤膜或者设置在多孔支撑结构上的另一穿孔二维材料。 执行血液透析的方法可以包括将患者的血液暴露于由穿孔的二维材料形成的血液透析膜。 可以类似地进行离体透析技术。 过滤血液的方法可以包括使血液通过一个或多个过滤膜或通过多个顺序的过滤膜。

公开(公告)号：US20140377738A1

公开(公告)日：2014-12-25

申请号：US13923503

申请日：2013-06-21

申请人： Lockheed Martin Corporation

发明人： Svetlana Monakhova BACHMANN ,  Paul Declan MOUNTCASTLE ,  Byron W. TIETJEN

IPC分类号： A61K35/14

CPC分类号： B01D71/021 ,  A61K35/14 ,  A61M1/1631 ,  A61M1/34 ,  A61M1/36 ,  A61M1/3633 ,  A61M2202/0014 ,  A61M2202/0042 ,  A61M2205/04 ,  B01D61/02 ,  B01D69/02 ,  B01D69/12 ,  B01D2325/02

摘要： A device isolates a substance from blood. The substance includes particles with an effective diameter that is within a range defined by effective diameters of constituents of blood. The device comprises a first sheet of graphene including a first plurality of apertures. The first plurality of apertures are configured to pass objects with an effective diameter less than or equal to the effective diameter of the particles of the substance. The device comprises a second sheet of graphene including a second plurality of apertures. The second plurality of apertures are configured to pass objects with an effective diameter less than the effective diameter of the particles of the substance. The device may be configured to include a conduit system. The device may be configured to operate according to a reversible cycle.

摘要翻译： 一种装置将物质与血液隔离。 该物质包括有效直径在由血液成分的有效直径限定的范围内的颗粒。 该装置包括包括第一多个孔的第一片石墨烯。 第一组多个孔被构造成传递有效直径小于或等于物质颗粒的有效直径的物体。 该装置包括包括第二多个孔的第二片石墨烯。 第二多个孔被构造成使物体的有效直径小于物质颗粒的有效直径。 该装置可以被配置为包括导管系统。 该装置可以被配置为根据可逆循环进行操作。

公开(公告)号：US06241945B1

公开(公告)日：2001-06-05

申请号：US09039318

申请日：1998-03-16

申请人： Donald R. Owen

发明人： Donald R. Owen

IPC分类号： A61M114

CPC分类号： A61M1/3627 ,  A61M1/1005 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/1086 ,  A61M1/1631 ,  A61M1/1698 ,  B01D63/082 ,  B01D65/00

摘要： A customized pump, filtration, oxygenation and/or debubbler apparatus includes a first pump module, a filtration module, an oxygenation module, a debubbler module and/or a second pump module. Each module is formed of stackable support members with filtration, oxygenation and/or degassing membranes interposed therebetween.

摘要翻译： 定制的泵，过滤，氧合和/或脱泡装置包括第一泵模块，过滤模块，氧合模块，脱泡器模块和/或第二泵模块。 每个模块由可叠置的支撑构件形成，其间插入有过滤，氧合和/或脱气膜。

公开(公告)号：US3879293A

公开(公告)日：1975-04-22

申请号：US48108174

申请日：1974-06-20

申请人： BAXTER LABORATORIES INC

发明人： WOLF JR LUDWIG ,  SEAVERNS ROBERT G

IPC分类号： A61M20060101 ,  A61M1/00 ,  A61M1/22 ,  B01D20060101 ,  B01D61/24 ,  B01D63/00 ,  B01D31/00

CPC分类号： B01D63/082 ,  A61M1/1631 ,  A61M1/26 ,  B01D2313/02 ,  B01D2313/20

摘要： A membrane diffusion device such as a membrane oxygenator is disclosed which comprises a stack of flat membrane wall pairs and flat membrane supports in alternating, interleaving relation. The stack is disposed in a casing and includes an inflatable member disposed between the opposite major faces of the stack and the casing. A flow conduit provides communication between the inflatable member and the exterior through the casing, to permit pressurization of the opposite major faces of the stack while simultaneously providing sealing for the same faces.

摘要翻译： 公开了一种膜扩散装置，例如膜氧合器，其包括一叠平坦的膜壁对和平坦的膜支架，交替的交错关系。 该堆叠设置在壳体中并且包括设置在堆叠的相对的主面和壳体之间的可充气构件。 流动管道通过壳体提供可膨胀构件和外部之间的连通，以允许对堆叠的相对的主面进行加压，同时为相同的面提供密封。

公开(公告)号：US3729098A

公开(公告)日：1973-04-24

申请号：US3729098D

申请日：1971-02-08

申请人： SERUR J

发明人： SERUR J

IPC分类号： A61M1/24 ,  B01D31/00

CPC分类号： B01D61/28 ,  A61M1/1631 ,  A61M1/1656 ,  A61M1/1668 ,  B01D63/068

摘要： Device for treating blood comprising an elongated tubular member of semi-permeable membrane defining a blood flow path, a pair of membrane supports extending adjacent the path on opposite sides of the membrane, each support having a series of protuberances extending longitudinally of the support and spaced across the width of the support, the protuberances of one support being spaced between and overlapping the protuberances of the other support to cause the tubular member to assume a zig-zag form across its width, the supports and the tubular member defining a multiplicity of flow channels outside the tubular member and extending along the path; blood inlet and outlet members adjacent opposite ends of the tubular member and communicating exclusively with the interior thereof; and treatment fluid inlet and outlet members adjacent opposite ends of the tubular member and communicating exclusively with the exterior thereof.

摘要翻译： 用于处理血液的装置，包括限定血液流动通道的细长的半透膜管状构件，邻近所述膜的相对侧上的路径延伸的一对膜支撑件，每个支撑件具有一系列沿支撑件纵向延伸的突起， 跨越支撑件的宽度，一个支撑件的突起在另一个支撑件的突起之间间隔开并且与另一个支撑件的突起重叠，以使管状构件跨越其宽度呈现锯齿状，支撑件和管状构件限定多个流动 通道在管状构件外部并沿着路径延伸; 血管入口和出口构件邻近管状构件的相对端并且仅与其内部连通; 以及处理流体入口和出口构件，其邻近管状构件的相对端并且仅与其外部连通。