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公开(公告)号：US20190231963A1
公开(公告)日：2019-08-01
申请号：US16261873
申请日：2019-01-30
申请人： B. BRAUN AVITUM AG
CPC分类号： A61M1/3656 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1623 , A61M1/1631 , A61M1/1647 , A61M1/3639 , A61M1/3655 , A61M1/3661 , A61M1/3663 , A61M2205/18 , A61M2205/3317 , A61M2205/3327 , A61M2205/3334 , A61M2205/3365 , A61M2205/3368 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： A device and method are used for monitoring an extracorporeal blood treatment device, such as a dialysis machine, which includes an extracorporeal blood circuit having an arterial blood line with an arterial patient port and/or at least one venous blood line with a venous patient port, and a dialysis fluid system which has a dialysis fluid supply line and a dialysis fluid drain line. The monitoring device selects and senses a measured value during operation of the extracorporeal blood treatment device which is suitable for monitoring the blood treatment device to compare a time-related actual course of the measured value with a target course of the measured value stored in a memory, and to determine that there is a defect if, at least in sections, the actual course of the measured value deviates from the target course by more than a defined tolerance.
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公开(公告)号：US20190209760A1
公开(公告)日：2019-07-11
申请号：US16302151
申请日：2017-04-27
申请人： Xenios AG
发明人： Ivo SIMUNDIC
CPC分类号： A61M1/1631 , A61M1/1036 , A61M1/1086 , A61M1/1698 , A61M1/3626 , A61M1/3639 , A61M1/3641 , A61M1/3666 , A61M2205/3334 , A61M2205/3365 , A61M2206/22 , A61M2230/04
摘要： In a system for extracorporeal membrane oxygenation including a blood pump and an oxygenator, the oxygenator includes fibrous mats stacked in a housing and arranged parallel to one another, and the blood pump includes a control unit that provides for a continuous variation of the volume of flow over time.
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公开(公告)号：US20180147336A1
公开(公告)日：2018-05-31
申请号：US15783757
申请日：2017-10-13
申请人： SiMPore, Inc.
IPC分类号： A61M1/16
CPC分类号： A61M1/1631 , B01D61/243 , B01D63/088 , B01D67/0037 , B01D67/0062 , B01D69/06 , B01D71/02 , B82Y40/00
摘要： Provided are nanoporous silicon nitride membranes and methods of making such membranes. The membranes can be part of a monolithic structure or free-standing. The membranes can be made by transfer of the nanoporous structure of a nanoporous silicon or silicon oxide film by, for example, reactive ion etching. The membranes can be used in, for example, filtration applications, hemodialysis applications, hemodialysis devices, laboratory separation devices, multi-well cell culture devices, electronic biosensors, optical biosensors, active pre-concentration filters for microfluidic devices.
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公开(公告)号：US20180104466A1
公开(公告)日：2018-04-19
申请号：US15837182
申请日：2017-12-11
CPC分类号： A61M1/16 , A61M1/14 , A61M1/1623 , A61M1/1629 , A61M1/1631 , A61M1/1694 , A61M1/28 , A61M1/281 , A61M1/282 , A61M1/288 , A61M5/16809 , A61M5/16813 , A61M5/16827 , A61M39/1011 , A61M39/105 , A61M39/20 , A61M39/28 , A61M39/281 , A61M2039/1066 , A61M2205/12 , A61M2205/121 , A61M2205/122 , A61M2205/123 , A61M2205/127 , A61M2205/128 , A61M2205/13 , A61M2205/14 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/36 , A61M2205/502 , A61M2209/08 , F04B43/02 , F04B43/08 , F04B43/086 , Y02A90/26
摘要： Components for a medical infusion fluid handling system, such as an APD system, in which one or more lines (such as solution lines), spikes or other connection ports may be automatically capped and/or de-capped. This feature may provide advantages, such as a reduced likelihood of contamination since no human interaction is required to de-cap and connect the lines, spikes or other connections. For example, a fluid handling cassette may include one or more caps that cover a corresponding spike and include a raised and/or recessed feature to assist in removal of the cap from the cassette. A solution line cap may include a hole and recess, groove or other feature to engage with a spike cap and enable removal of the cap.
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公开(公告)号：US20140061115A1
公开(公告)日：2014-03-06
申请号：US13604256
申请日：2012-09-05
CPC分类号： A61M1/34 , A61M1/16 , A61M1/1631 , A61M1/1698 , A61M1/3403 , A61M1/36 , A61M2202/0413 , A61M2205/0244 , A61M2205/75 , B01D61/243 , B01D63/005 , B01D63/082 , B01D63/085 , B01D63/088 , B01D2313/08 , B01D2313/105 , B01D2319/04 , B01L3/5027 , B01L2300/0864 , B01L2300/0874 , F17D1/00 , Y10T137/794
摘要： An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
摘要翻译： 提供了一种用于输送剪切敏感流体的紧凑型液压歧管。 信道网络可以包括耦合到分叉架构的中继线和分支架构。 可以使用诸如锥形通道壁，通道的曲率和通道角度以及低流体压力的区域来减小尺寸，同时将壁剪切速率保持在窄范围内。 液压歧管可以连接到一系列微流体层以构造紧凑的微流体装置。
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公开(公告)号：US20040009096A1
公开(公告)日：2004-01-15
申请号：US10455543
申请日：2003-06-05
发明人： Parris S. Wellman
IPC分类号： A61M037/00 , A61M001/34 , C02F001/44
CPC分类号： A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1627 , A61M1/1631 , A61M1/32 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M1/3661 , A61M2206/11
摘要： This invention is a membraneless filtration device and a method for performing hemodialysis on a patient using it and methods of manufacturing the filtration device. In a preferred embodiment, the filter is composed of at least one channel where the dialysate circumferentially surrounds the blood to reduce or eliminate the need for anticoagulation through reduced hemolysis and thrombogenicity. In the preferred embodiment the filter is configured to be used with a typical dialysis machine and hemodialysis is separated into an iso- or hyper-volemic filtration phase, followed by a phase where the patient's blood volume is reduced to normal levels. In another embodiment the device is adapted to be implanted or worn externally to serve as a portable artificial kidney. The device described herein could also find application as a blood oxygenator in cardiopulmonary bypass, or for use as an artificial liver or lung.
摘要翻译： 本发明是一种无膜过滤装置和使用其的患者进行血液透析的方法和制造该过滤装置的方法。 在优选实施方案中，过滤器由至少一个通道组成，其中透析液周向地包围血液，以减少或消除通过降低溶血和血栓形成的抗凝作用。 在优选实施例中，过滤器被配置为与典型的透析机一起使用，血液透析被分离成异位或超高压过滤阶段，之后是患者血液体积减少到正常水平的阶段。 在另一个实施例中，该装置适于在外部植入或磨损以用作便携式人造肾。 本文描述的装置也可以用作心肺旁路中的血液充氧器，或用作人造肝或肺。
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公开(公告)号：US4229290A
公开(公告)日：1980-10-21
申请号：US886458
申请日：1978-03-14
申请人： Ghen M. G. Raj
发明人： Ghen M. G. Raj
CPC分类号： B01D61/28 , A61M1/1631 , B01D61/243 , B01D63/082 , B01D2313/143
摘要： A compact blood dialyzer is described having a low surface area of semi-permeable membrane as compared with the dialyzer systems in use today. The dialyzer can be manufactured at relatively low cost to be provided as a presterilized unit feasible for use in dialysis at home. Arterial pressure can pump the blood through the compact dialyzer unit. The blood and dialysate flow in multiple parallel channels on opposite sides of the semi-permeable membranes, with the blood being directed as wide thin films travelling against the surface of the membrane, thereby providing an efficient exposure of the flowing blood to the surface of the membrane. Advantageously, the blood flows upwardly in its channels against gravity for assuring complete filling of each and every channel with the blood being effectively pushed against the surface of the membrane for enhancing the osmotic action. The dialyzer unit is shown flexed into an arc during usage for clamping the plates firmly against the membrane sandwiched between them.
摘要翻译： 与目前使用的透析器系统相比，描述了具有低半透膜面积的紧凑型血液透析器。 透析器可以相对较低的成本制造，作为可在家中透析使用的预先灭菌的单元。 动脉压力可以通过紧凑型透析器单元泵送血液。 血液和透析液在半透膜的相对侧上的多个平行通道中流动，血液被引导为宽薄薄膜，该薄膜沿膜的表面行进，从而提供流动的血液有效地暴露于 膜。 有利地，血液在其通道中向上流动反对重力，以确保每个通道完全充满，血液被有效地推压在膜的表面上以增强渗透作用。 在使用期间，透析器单元被弯曲成弧形，将板牢固地夹在夹在它们之间的膜上。
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8.发明授权公开(公告)号：US11833281B2
公开(公告)日：2023-12-05
申请号：US17975495
申请日：2022-10-27
发明人： David W. McGill , James D. Dale , Simon C. Helmore , Richard J. Lanigan , Jason A. Demers , Dean Kamen
IPC分类号： A61M1/14 , A61M1/16 , A61M5/168 , A61M39/10 , A61M39/28 , A61M1/28 , F04B43/02 , F04B43/08 , F04B43/073 , A61M39/20
CPC分类号： A61M1/15 , A61M1/14 , A61M1/155 , A61M1/156 , A61M1/1562 , A61M1/1565 , A61M1/16 , A61M5/16809 , A61M1/1601 , A61M1/166 , A61M1/1623 , A61M1/1629 , A61M1/1631 , A61M1/1694 , A61M1/28 , A61M1/281 , A61M1/282 , A61M1/288 , A61M5/16813 , A61M5/16827 , A61M39/105 , A61M39/1011 , A61M39/20 , A61M39/28 , A61M39/281 , A61M2039/1066 , A61M2205/12 , A61M2205/121 , A61M2205/122 , A61M2205/123 , A61M2205/127 , A61M2205/128 , A61M2205/13 , A61M2205/14 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/36 , A61M2205/502 , A61M2209/08 , F04B43/02 , F04B43/073 , F04B43/08 , F04B43/086 , Y02A90/10
摘要： A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.
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公开(公告)号：US11738130B2
公开(公告)日：2023-08-29
申请号：US17568697
申请日：2022-01-04
发明人： Simon C. Helmore , David W. McGill , David J. Hibbard , James D. Dale , Matthew J. Finch , Jesse T. Bodwell , Jason A. Demers
IPC分类号： A61M1/28 , A61M1/14 , A61M39/20 , A61M5/168 , A61M1/16 , A61M39/10 , A61M39/28 , F04B43/02 , F04B43/08 , F04B43/073
CPC分类号： A61M1/288 , A61M1/14 , A61M1/28 , A61M5/16809 , A61M39/20 , A61M1/16 , A61M1/1601 , A61M1/166 , A61M1/1623 , A61M1/1629 , A61M1/1631 , A61M1/1694 , A61M1/281 , A61M1/282 , A61M5/16813 , A61M5/16827 , A61M39/105 , A61M39/1011 , A61M39/28 , A61M39/281 , A61M2039/1066 , A61M2205/12 , A61M2205/121 , A61M2205/122 , A61M2205/123 , A61M2205/127 , A61M2205/128 , A61M2205/13 , A61M2205/14 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/36 , A61M2205/502 , A61M2209/08 , F04B43/02 , F04B43/073 , F04B43/08 , F04B43/086 , Y02A90/10
摘要： A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the one or more lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.
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公开(公告)号：US20160339160A1
公开(公告)日：2016-11-24
申请号：US15099588
申请日：2016-04-14
发明人： Peter V. Bedworth , Steven Edward Bullock , Sarah M. Simon , Steven W. Sinton , John. B. Stetson , Jacob L. Swett , Scott E. Heise
IPC分类号： A61M1/16 , B01D61/24 , B01D71/02 , H01J37/305
CPC分类号： A61M1/1623 , A61M1/1621 , A61M1/1631 , A61M2207/00 , B01D61/243 , B01D67/0062 , B01D67/0069 , B01D67/0072 , B01D69/10 , B01D71/021 , H01J37/3056 , H01J2237/3174
摘要： Various systems and methods relating to two-dimensional materials such as graphene. A membrane include a cross-linked graphene platelet polymer that includes a plurality of cross-linked graphene platelets. The cross-linked graphene platelets include a graphene portion and a cross-linking portion. The cross-linking portion contains a 4 to 10 atom link. The cross-linked graphene platelet polymer is produced by reaction of an epoxide functionalized graphene platelet and a (meth)acrylate or (meth)acrylamide functionalized cross-linker.
摘要翻译： 与二维材料如石墨烯有关的各种系统和方法。 膜包括交联石墨烯血小板聚合物，其包括多个交联的石墨烯血小板。 交联石墨烯片晶包括石墨烯部分和交联部分。 交联部分含有4〜10个原子连接。 交联石墨烯血小板聚合物通过环氧化物官能化的石墨烯片和（甲基）丙烯酰胺官能化交联剂的反应制备。
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