公开(公告)号：US5808095A

公开(公告)日：1998-09-15

申请号：US946393

申请日：1997-10-07

申请人： Yadagiri R. Pendri ,  Eduardo J. Martinez ,  John K. Thottathil ,  Piyasena Hewawasam

发明人： Yadagiri R. Pendri ,  Eduardo J. Martinez ,  John K. Thottathil ,  Piyasena Hewawasam

IPC分类号： C07C205/56 ,  C07D209/34 ,  C07D209/12

CPC分类号： C07C201/12 ,  C07C227/04 ,  C07D209/34 ,  Y02P20/55

摘要： The present invention relates to novel intermediates of the formula ##STR1## wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer; and R is hydrogen, a carboxyl-protecting group or a cation of an addition salt; or solvate thereof; and to the use thereof in a process for the preparation of certain 3-fluoro oxindole derivatives.

公开(公告)号：US5498733A

公开(公告)日：1996-03-12

申请号：US93029

申请日：1993-07-19

申请人： Folahan O. Ayorinde ,  Chukwuma P. Nwaonicha

发明人： Folahan O. Ayorinde ,  Chukwuma P. Nwaonicha

IPC分类号： C07C227/04 ,  C07C229/08 ,  C11B1/00 ,  C11C1/02

CPC分类号： C07C227/04

摘要： Nylon-11 monomer, 11-aminoundecanoic acid, is synthesized from 12-oxododecanoic acid oxime in a three-step reaction sequence which involves a Beckmann rearrangement, Hofmann degradation and hydrolysis. The aldoxime acid is hydrolyzed in the presence of nickel acetate tetrahydrate to give 11-carbamoylundecanoic acid. This amide is then treated with a solution of sodium methoxide and bromine at 70.degree.-80.degree. C. to give 11-(methoxycarbonylamino)undecanoic acid, which upon basic hydrolysis and subsequent neutralization, yields the 11-aminoundecanoic acid.

摘要翻译： 尼龙-11单体，11-氨基十一烷酸，由12-氧代十二烷酸肟合成的三步反应顺序涉及贝克曼重排，霍夫曼降解和水解。 醛肟酸在乙酸镍四水合物的存在下水解，得到11-氨基甲酰基十一烷酸。 然后用甲醇钠和溴的溶液在70-80℃处理该酰胺，得到11-（甲氧基羰基氨基）十一烷酸，其在碱性水解和随后的中和反应后得到11-氨基十一烷酸。

公开(公告)号：US5136091A

公开(公告)日：1992-08-04

申请号：US786777

申请日：1991-11-01

申请人： Hans P. Mettler ,  Felix Previdoli

发明人： Hans P. Mettler ,  Felix Previdoli

IPC分类号： C07C227/04 ,  C07C229/28 ,  C07C255/46

CPC分类号： C07C255/46 ,  C07C227/04 ,  C07C229/28 ,  C07C2101/14

摘要： A new process is described for the production of 1-(aminomethyl)cyclohexane acetic acid, a pharmaceutical agent used as an anticonvulsant. For this purpose a (1-cyanocyclohexyl)-malonic acid dialkyl ester is decarbalkoxylated to the corresponding (1-cyanocyclohexyl)acetic acid alkyl ester, then transesterified with a benzyl alcohol and finally hydrogenated to form the end product.

摘要翻译： 描述了用于生产用作抗惊厥药的药物的1-（氨基甲基）环己烷乙酸的新方法。 为此，（1-氰基环己基） - 丙二酸二烷基酯对相应的（1-氰基环己基）乙酸烷基酯进行脱烷基氧化，然后用苄醇酯交换并最终氢化形成最终产物。

公开(公告)号：US4973746A

公开(公告)日：1990-11-27

申请号：US261800

申请日：1988-10-24

申请人： Kenneth P. Blackmon ,  Daniel W. Fox ,  Sheldon J. Shafer

发明人： Kenneth P. Blackmon ,  Daniel W. Fox ,  Sheldon J. Shafer

IPC分类号： C07C27/00 ,  C07C29/09 ,  C07C31/20 ,  C07C209/48 ,  C07C209/50 ,  C07C211/18 ,  C07C211/27 ,  C07C227/04 ,  C07C229/38 ,  C07C231/02 ,  C07C233/65 ,  C07C253/20 ,  C07C255/51

CPC分类号： C07C209/48 ,  C07C227/04 ,  C07C231/02 ,  C07C253/20 ,  C07C253/30 ,  C07C2101/14

摘要： Scrap poly(ethyleneterephthalate) is converted to useful amine and diamine monomers such as para-xylylenediamine, 1,4-bis(aminomethyl)cyclohexane and 4-aminomethyl benzoic acid for the production of various polyamides. The conversion of poly(ethyleneterephthalate) to diamine monomers is achieved by a three step process involving (a) ammonolysis of the poly(ethyleneterephthalate) to produce terephthalamide and ethylene glycol; (b) pyrolytic dehydration of the terephthalamide to produce terephthalonitrile; and (c) hydrogenation of the terephthalonitrile to produce the para-xylylene diamine and/or 1,4-bis(aminomethyl)cyclohexane. The conversion of poly(ethyleneterephthalate) to 4-aminomethyl benzoic acid involves the steps of (a) ammonolysis of the poly(ethyleneterephthalate) to produce terephthalamide; (b) partial pyrolytic dehydration of said terephthalamide to produce 4-cyanobenzoic acid; and (c) hydrogenation of said 4-cyanobenzoic acid to produce 4-aminomethylbenzoic acid. The process of the present invention permits the conversion of low value PET scrap such as beverage bottles, fibers and film to relatively high value and relatively pure diamine monomers and ethylene glycol.

公开(公告)号：US4414084A

公开(公告)日：1983-11-08

申请号：US409268

申请日：1982-08-18

申请人： Truman L. Ward ,  Ruth R. Benerito

发明人： Truman L. Ward ,  Ruth R. Benerito

IPC分类号： C07C227/04 ,  C07G13/00

CPC分类号： C07C227/04

摘要： This invention relates to a process for converting cellulose to amino acids by radiofrequency plasma of nitrogen and hydrogen gases. Cellulose is placed between the electrodes in a radiofrequency plasma reaction chamber which is sealed and maintained at a reduced pressure. Hydrogen and nitrogen mixture is bled through the chamber and sufficient radiofrequency electric current applied until the cellulose is consumed, thereby producing a mixture of amino acids. The cellulose can be either cotton or wood derivatives.

摘要翻译： 本发明涉及通过氮气和氢气的射频等离子体将纤维素转化为氨基酸的方法。 纤维素被放置在射频等离子体反应室中的电极之间，其被密封并保持在减压下。 氢气和氮气混合物通过室排放，施加足够的射频电流直到纤维素消耗，从而产生氨基酸的混合物。 纤维素可以是棉花或木材衍生物。

公开(公告)号：US3728376A

公开(公告)日：1973-04-17

申请号：US3728376D

申请日：1970-06-15

申请人： UNIVERSAL OIL PROD CO

发明人： LEVY J ,  WALKER W

IPC分类号： C07C227/04 ,  C07C101/18

CPC分类号： C07C227/04

摘要： Catalytic reduction of an ester of a nitrobenzoic acid and tertiary-amino alcohol to the corresponding amine by gradually adding the ester to an agitated suspension of noble metal catalyst in inert water immiscible solvent under hydrogen pressure. Improved yields and product purity are obtained in a more facile manner.

摘要翻译： 通过在氢气压力下将惰性水不混溶性溶剂中的贵金属催化剂的搅拌悬浮液逐渐加入，将硝基苯甲酸和叔氨基醇的酯催化还原成相应的胺。 以更容易的方式获得提高的产率和产物纯度。

公开(公告)号：US3488363A

公开(公告)日：1970-01-06

申请号：US3488363D

申请日：1965-10-22

申请人： MERCK & CO INC

发明人： HINKLEY DAVID FREDERICK

IPC分类号： C07C205/53 ,  C07D317/60 ,  C07D13/10 ,  C07C99/00

CPC分类号： C07C205/53 ,  C07C201/12 ,  C07C227/04 ,  C07D317/60 ,  C07C229/36

摘要： Compounds of formula wherein n is 0 or 1, R1 and R2 are H, C1- 5 alkyl, C1- 6 alkanoyl, or alkoxyalkyl, or together form CH2, Z is CH2 or CO and X is -C(CH3)(NO2) -CO2R3 (R3 = C1- 5 alkyl), are prepared by reacting the halide of the above formula (X = Br or Cl) with HC(CH3)(NO2)CO2R3. The products may be reduced to corresponding amino-esters of said formula, wherein Z is CH2 or CHOH, and X is -C(CH3)(NH2)CO2R3.

公开(公告)号：US2839547A

公开(公告)日：1958-06-17

申请号：US60039956

申请日：1956-07-27

申请人： INVENTA AG

发明人： CLAU BERTHER

IPC分类号： B01J41/04 ,  C07C227/04

CPC分类号： B01J41/04 ,  C07C227/04

公开(公告)号：US1917311A

公开(公告)日：1933-07-11

申请号：US48081630

申请日：1930-09-09

申请人： SCOTTISH DYES LTD

发明人： JENKIN LOVELUCK RHYS ,  JOHN THOMAS

IPC分类号： C07C205/61

CPC分类号： C07C205/61 ,  C07C51/363 ,  C07C65/34 ,  C07C201/08 ,  C07C227/04 ,  C07C229/66

公开(公告)号：US690325A

公开(公告)日：1901-12-31

申请号：US1901062126

申请日：1901-05-27

申请人： BASF AG

发明人： SEIDEL PAUL

CPC分类号： C07C227/04