公开(公告)号：US20230037864A1

公开(公告)日：2023-02-09

申请号：US17851277

申请日：2022-06-28

Applicant: Academia Sinica

Inventor： Shang-Te Danny HSU ,  Hui-Wen CHANG ,  Chia-Yu CHANG

IPC: C07K16/10 ,  G01N33/569

Abstract: Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.

公开(公告)号：US20230036162A1

公开(公告)日：2023-02-02

申请号：US17966281

申请日：2022-10-14

Applicant: Academia Sinica

Inventor： Ying-Chih CHANG

IPC: C12N5/09 ,  G01N33/50

Abstract: The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.

公开(公告)号：US11568151B2

公开(公告)日：2023-01-31

申请号：US17099867

申请日：2020-11-17

Applicant: ACADEMIA SINICA

Inventor： Wen-Lian Hsu

IPC: G06F40/30 ,  G06F40/295 ,  G06F40/58 ,  G06F40/284 ,  G06F40/253 ,  G06F40/263

Abstract: A natural language processing method, comprising: receiving multiple input words; and reducing the multiple words into one or more subject word data structures according to sets stored in a database, wherein one of the subject word data structures includes a first input word and a second input words among the input words, wherein one of the sets includes a compatible relation between the first input word and the second input word, wherein the compatible relation between the first input word and the second word includes a compatible property for denoting an intensity representing occurrences of the first input word and the second word in a training corpus.

公开(公告)号：US20230022210A1

公开(公告)日：2023-01-26

申请号：US17946651

申请日：2022-09-16

Applicant: Academia Sinica

Inventor： Po-Wen CHUNG ,  Meng-Xun WU

IPC: B01J37/03 ,  B01J23/02 ,  B01J21/08 ,  B01J35/10 ,  B01J37/02 ,  B01J37/10

Abstract: Metal oxides-silica composite materials are synthesized by a co-precipitation method to serve as modified catalysts for converting ethanol into four-carbon hydrocarbons. The method includes mixing a liquid-phase silicon source and a metal precursor at different ratios so as to change the acid-base composition of the composite materials and thereby increase selectivity with respect to the four-carbon products.

公开(公告)号：US20230010562A1

公开(公告)日：2023-01-12

申请号：US17811880

申请日：2022-07-12

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Chi-Huey Wong ,  Pan-Chyr Yang ,  Rong-Jie Chein ,  Szu-Hua Pan ,  Ting-Jen R. Cheng

IPC: C07D405/12 ,  C07D307/92 ,  C07D403/12 ,  C07D413/12

Abstract: The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).

公开(公告)号：US20230010294A1

公开(公告)日：2023-01-12

申请号：US17782595

申请日：2020-12-02

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin YANG ,  Yang-Han LEE ,  Yu-Chuan LIANG ,  Frederick Kin Hing PHOA ,  Lee-Tian CHANG ,  Cheng-Chih HSU ,  Jia-Kun CHEN ,  Shau-Ping LIN ,  Chiao-LING HSIAO

IPC: A01K45/00 ,  A01K31/18 ,  A01K13/00

Abstract: A system for use in a poultry house includes a control server, a network gateway disposed in the poultry house and equipping with a wireless communication capability; a movable sensor module disposed in the poultry house, wherein the movable sensor module is movable within the poultry house for obtaining a plurality of environmental parameters associated with specific locations within the poultry house, and a sampling machine disposed in the poultry house for obtaining a sample of poultry waste on the ground of the poultry house. The movable sensor module transmits the environmental parameters to the network gateway, and the network gateway transmits the environmental parameters to the control server for processing the environmental parameters.

公开(公告)号：US20220409552A1

公开(公告)日：2022-12-29

申请号：US17779048

申请日：2020-11-25

Applicant: The Johns Hopkins University ,  Academia Sinica ,  National Chiao Tung University

Inventor： Ru Chih C. Huang ,  Jong Ho Chun ,  Yu-Ling Lin ,  Yu-Chuan LIang ,  Kuang-Wen Liao ,  Tiffany Jackson ,  David Mold ,  Chien-Hsien Lai

IPC: A61K31/05 ,  A61K31/09 ,  A61K31/444 ,  A61K31/495 ,  A61P35/00 ,  A61K47/22 ,  A61K47/14 ,  A61K9/00

Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

公开(公告)号：US20220403044A1

公开(公告)日：2022-12-22

申请号：US17756022

申请日：2020-11-16

Applicant: ACADEMIA SINICA

Inventor： Han-Chung WU ,  Hao-Nien CHEN

IPC: C07K16/30 ,  A61P35/00 ,  A61P11/00 ,  C07K16/28 ,  A61P15/00 ,  A61P1/00 ,  C12N15/113

Abstract: The present disclosure relates to therapeutic use of anti-EpCAM antibodies. Also provided is a combination immune therapy of an anti-EpCAM antibody and a PD-L1 immune checkpoint inhibitor.

公开(公告)号：US11524978B2

公开(公告)日：2022-12-13

申请号：US16823356

申请日：2020-03-19

Applicant: Academia Sinica

Inventor： Han-Chung Wu ,  Yuan-Sung Kuo

IPC: C07K7/06 ,  A61K47/64 ,  A61K38/43

Abstract: Disclosed herein is a biomolecule comprising a synthetic peptide for targeting thrombus, a pharmaceutical composition comprising the same, and uses thereof in the treatment of thromboembolism-related diseases. According to embodiments of the present disclosure, the synthetic peptide having the amino acid sequence of SEQ ID NO: 1, 2, or 3 exhibits a binding affinity and specificity to thrombus. Thus, the synthetic peptide may serve as a targeting element for delivering a therapeutic agent (e.g., an anticoagulant agent or a thrombolytic agent) to the thrombus thereby improving the therapeutic safety and efficacy of the therapeutic agent.

公开(公告)号：US11505523B2

公开(公告)日：2022-11-22

申请号：US16405581

申请日：2019-05-07

Applicant: City of Hope ,  Taipei Medical University ,  Academia Sinica

Inventor： Ya-Huei Kuo ,  Wei-Jan Huang ,  Chung-I Chang

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  C07C259/06 ,  C07D213/74 ,  C07D215/14 ,  C07D217/16 ,  C07D317/60 ,  C07D333/24 ,  C07D209/08 ,  C07D209/18 ,  C07D213/56 ,  C07D307/91 ,  C07D217/20

Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.