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    METHODS FOR ENHANCING PERMEABILITY TO BLOOD-BRAIN BARRIER, AND USES THEREOF
    553.
    发明申请
    METHODS FOR ENHANCING PERMEABILITY TO BLOOD-BRAIN BARRIER, AND USES THEREOF 有权

    公开(公告)号：US20210275640A1

    公开(公告)日：2021-09-09

    申请号：US17327565

    申请日：2021-05-21

    Applicant: ACADEMIA SINICA

    Inventor： Patrick C.H. Hsieh ,  David Lundy

    IPC: A61K38/18 ,  A61K45/06 ,  A61K47/68 ,  A61K51/08

    Abstract: Disclosed herein is a method of facilitating the delivery of an agent across blood-brain barrier (BBB) of a subject. The method includes administering to the subject in sequence or concomitantly, an effective amount of a growth factor selected from the group consisting of, vascular endothelial growth factor (VEGF), insulin-like growth factor I (IGF-1), IGF-II, a portion thereof and a combination thereof; and an agent that is any of a therapeutic agent or an imaging agent. The administered amount of the growth factor is capable of transiently increasing BBB permeability of the subject and thereby allowing the agent to be delivered across BBB. Also disclosed herein is a method of treating a subject suffering from a brain tumor, a brain stroke, a neuropsychiatric disorder and/or a neurodegenerative disease.

    Broadband achromatic metalens in the visible spectrum
    556.
    发明授权
    Broadband achromatic metalens in the visible spectrum 有权

    公开(公告)号：US11079520B2

    公开(公告)日：2021-08-03

    申请号：US16231868

    申请日：2018-12-24

    Applicant: ACADEMIA SINICA

    Inventor： Din-Ping Tsai ,  Pin-Chieh Wu

    IPC: G02B5/00 ,  G02F1/00 ,  G02B1/00 ,  B82Y20/00

    Abstract: In this disclosure, an optical component which comprises an array of metalenses is provided. Each metalens comprises a plurality of nanostructures and a dielectric layer and the nanostructures are disposed on the dielectric layer, and the nanostructures comprises an array of first phase compensation structures, and an array of second phase compensation structures. The array of the first phase compensation structures are disposed to surround the array of the second phase compensation structures so as to define a single metalens. The first and second phase compensation structures are complementary to each other and substantially satisfy the Babinet's principle.

    PARASPECKLE COMPONENT 1 (PSPC1) PROMOTING EPITHELIAL-MESENCHYMAL TRANSITION, STEMNESS AND METASTASIS AS AN ANTI-CANCER TARGET
    558.
    发明申请
    PARASPECKLE COMPONENT 1 (PSPC1) PROMOTING EPITHELIAL-MESENCHYMAL TRANSITION, STEMNESS AND METASTASIS AS AN ANTI-CANCER TARGET 有权

    公开(公告)号：US20210087239A1

    公开(公告)日：2021-03-25

    申请号：US16970350

    申请日：2020-02-12

    Applicant: Academia Sinica

    Inventor： Yuh-Shan JOU ,  Yaw-Dong LANG ,  Hsi-Wen YEH

    IPC: C07K14/47 ,  C12N15/63

    Abstract: An isolated nucleic acid encoding a C-terminal fragment of paraspeckle component 1 (PSPC1) is disclosed. The C-terminal fragment of the PSPC1 comprises an extension of more than 10 but no greater than 131 amino acid residues with its C-terminal amino acid identical to the C-terminus of the PSPC1 sequence SEQ ID NO: 3 and exhibits a biological activity against tumor cells. The tumor cells are associated with either PSPC1 or protein tyrosine kinase 6 (PTK6), or both. The anti-tumor activity is at least one selected from the group consisting of: (a) suppressing tumor cell growth; (b) suppressing tumor cell progression; (c) suppressing tumor cell metastasis; (d) decreasing PSPC1 expression; and (e) decreasing oncogenic PTK6 expression in cytoplasm. Also disclosed is a peptide comprising a C-terminal fragment sequence of PSPC1. A reagent kit and method for predicting tumor progression, metastasis, and prognosis in a cancer patient are also disclosed.

    Multi-drug delivery system and uses thereof
    560.
    发明授权
    Multi-drug delivery system and uses thereof 有权

    公开(公告)号：US10912832B2

    公开(公告)日：2021-02-09

    申请号：US16697810

    申请日：2019-11-27

    Applicant: Academia Sinica

    Inventor： Patrick C. H. Hsieh ,  Pei-Jung Wu ,  Steve Roffler ,  Bill Cheng

    IPC: A61K39/395 ,  C07K16/44 ,  A61K9/00 ,  A61K47/36 ,  A61K47/42 ,  A61K47/68 ,  A61K47/60 ,  A61K9/06 ,  A61K38/00

    Abstract: Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for retaining the anti-PEG antibody and/or the PEGylated therapeutic at the treatment site for at least 3 days. The hydrogel is selected from the group consisting of hyaluronan (HA) or a derivative of HA, collagen, gelatin, fibronectin, fibrinogen, alginate, chitosan, and a synthetic biocompatible polymer. The anti-PEG antibody and the hydrogel are present in the mixture in a ratio from about 1:1 (v/v) to 1:100 (v/v). At least two dosages of the PEGylated therapeutic, which may be the same or different, are administered to the subject, with each dosage being given at about 1 hour to about 1 week apart. Accordingly, a novel method of treating a subject having cancer or ischemia disease is also provided.

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