公开(公告)号：US20180243402A1

公开(公告)日：2018-08-30

申请号：US15756774

申请日：2016-09-09

Applicant: Academia Sinica

Inventor： Shu-Mei LIANG ,  Pei-Wen HSIAO ,  Ming-Chu CHENG ,  Yu-Chih YANG

IPC: A61K39/145 ,  A61K39/135

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/5258 ,  A61K2039/552 ,  A61K2039/555 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/572 ,  A61K2039/70 ,  A61P31/16 ,  C12N7/00 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/00034 ,  C12N2770/32122 ,  C12N2770/32123

Abstract: A vaccine composition is disclosed. The vaccine composition comprises: (a) a therapeutically effective amount of an influenza virus-like particle (VLP) comprising: (i) influenza M1, influenza M2, influenza hemagglutinin (HA), and influenza neuraminidase (NA) proteins; (b) Foot-and-mouth disease virus (FMDV) capsid protein VP3, recombinant FMDV VP3 (rVP3), VP3 peptide, or SUMO VP3; and (c) alum. Also disclosed is use of a vaccine composition according to the invention in the manufacture of a medicament for inducing an immunogenic response in a subject in need thereof.

公开(公告)号：US20170360863A1

公开(公告)日：2017-12-21

申请号：US15534089

申请日：2015-12-09

Applicant: Academia Sinica

Inventor： Ning-Sun YANG ,  Wen-Chi WEI ,  Sheng-Yen LIN ,  Pei-Wen HSIAO ,  Yet-Ren CHEN

IPC: A61K36/28 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00 ,  A61K45/06

CPC classification number: A61K36/28 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2236/00 ,  C07K16/2803 ,  C07K2317/92

Abstract: A pharmacological composition for use in inhibiting differentiation, functional activities, and population of granulo-cytic myeloid-derived suppressor cells (gMDSCs) and/or suppressing, tumor metastasis in a subject in need thereof is disclosed. The composition comprises a therapeutically effective amount of Bidens pilosa extract, or more than one polyacetylenic compounds purified or isolated from the B. pilosa extract, and a pharmaceutically acceptable carrier.

公开(公告)号：US20210254168A1

公开(公告)日：2021-08-19

申请号：US16972984

申请日：2019-06-10

Applicant: ACADEMIA SINICA

Inventor： Pei-Wen HSIAO ,  Chin-Hsien TSAI ,  Sheue-Fen TZENG ,  Shih-Chuan HSIEH ,  Ming-Shyue LEE

IPC: C12Q1/6886 ,  G01N33/574

Abstract: The present invention relates to biomarkers, methods and assay kits for predicting prognosis and/or monitoring progression of prostate cancer. The biomarkers include a glycosyltransferases [core 1 beta-3-galactosyltransferase (C1GALT1) and/or ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1)] gene product, its saccharide substrate/product, and/or a galectin-4 gene product.

公开(公告)号：US20140142157A1

公开(公告)日：2014-05-22

申请号：US13929444

申请日：2013-06-27

Applicant: ACADEMIA SINICA ,  JIN XIN BIOTECHNOLOGY CO., LTD.

Inventor： Kun-Hsuan HUANG ,  Tza-Zen CHANG ,  Pei-Wen HSIAO ,  Chia-Jui TSAI

IPC: A61K36/12 ,  A61K31/232 ,  A61K31/231 ,  A61K31/409

CPC classification number: A61K36/12 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/23 ,  A61K31/231 ,  A61K31/232 ,  A61K31/409 ,  A23V2200/30

Abstract: An extract of Asplenium nidus L. includes pyropheophorbide a methyl ester (C34H36N4O3), pheophorbide a methyl ester (C35H36N4O5), 1-linleoyl-3-linolenoyl-glycerol (C39H66O5), 1-linleoyl-2,3-dipalmitoyl-rac-glycerol (C53H98O6) and 1,3-dipalmitoyl-sn-glycerol (C35H68O5). The extract of Asplenium nidus L. is obtained by using a method including steps of: solvent extraction, using an solvent to extract an Asplenium nidus L. sample and to obtain an extract, with a w/v ratio between the solvent and the Asplenium nidus L. sample being 50-60 mg/ml; and column chromatography, fractionating the extract with water and ethanol as eluent to obtain several fractions including fraction a to fraction i, and further evaporating and lyophilizing fraction b, c, d or their combination to obtain an extract of Asplenium nidus L.

Abstract translation: of藜提取物包括焦脱镁叶酸甲酯（C34H36N4O3），偏硼酸甲酯（C35H36N4O5），1-亚麻酰-3-亚油酸 - 甘油（C39H66O5），1-亚麻酰基-2,3-二棕榈酰基 - 外消旋甘油 （C53H98O6）和1,3-二棕榈酰基-sn-甘油（C35H68O5）。 通过使用以下方法获得of The提取物，该方法包括以下步骤：溶剂萃取，使用溶剂萃取an an L. L. L. L. L. and and and and L L L L L L L L L L L L L 样品为50-60 mg / ml; 和柱色谱法，用水和乙醇作为洗脱液将提取物分馏，得到几种级分，包括级分a至级分i，并进一步蒸发和冻干级分b，c，d或其组合，得到As an提取物。