公开(公告)号：US20120003684A1

公开(公告)日：2012-01-05

申请号：US13255976

申请日：2010-03-10

申请人： Peter Dieter ,  Anne-Helen Lutter ,  Ute Hempel

发明人： Peter Dieter ,  Anne-Helen Lutter ,  Ute Hempel

IPC分类号： C12Q1/02

CPC分类号： G01N33/5044 ,  G01N33/84

摘要： The invention relates to a method and means for detecting the resorption activity of osteoclasts, in particular for use in medicine and in bioscience and pharmaceutical research. Previous methods for measuring the resorption activity of osteoclasts in vitro are difficult to quantify, are partially inflexible when used with different donor organisms and require special measuring devices for data acquisition. The method and kit according to the invention advantageously use a biomineralized matrix which contains calcium phosphate and was obtained in vitro by depositing calcium phosphate by means of osteoblasts. Osteoclasts are incubated on this matrix and the non-resorbed calcium phosphate is then quantified. The method according to the invention advantageously functions with osteoclasts of different organisms and cell types and can be easily quantified.

摘要翻译： 本发明涉及一种用于检测破骨细胞吸收活性的方法和手段，特别是用于医学和生物科学和制药研究中。 用于测量体外破骨细胞吸收活性的先前方法难以量化，当与不同的供体生物体一起使用时需要部分不灵活，并且需要用于数据采集的特殊测量装置。 根据本发明的方法和试剂盒有利地使用含有磷酸钙的生物矿化基质，并且通过用成骨细胞沉积磷酸钙在体外获得。 破骨细胞在该基质上孵育，然后定量未吸附的磷酸钙。 根据本发明的方法有利地用于不同生物体和细胞类型的破骨细胞，并且可以容易地量化。

公开(公告)号：US20110189657A1

公开(公告)日：2011-08-04

申请号：US12666303

申请日：2008-06-27

申请人： Kai Ostermann ,  Wolfgang Pompe ,  Gerhard Rodel ,  Annett Gross

发明人： Kai Ostermann ,  Wolfgang Pompe ,  Gerhard Rodel ,  Annett Gross

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6897

摘要： The invention relates to a device and a method for the detection and amplification of a primary signal, utilizing an intracellular communication system, and the use thereof for the detection of substances such as phosphorus, sulfur, nitrogen, hormones, metabolic intermediates, fermentation products, and so forth. The device according to the invention for the detection and amplification of a primary signal contains cells of a first type for which a gene, which is responsible for the synthesis of a signal molecule, is under the control of a promoter which is regulated by the primary signal, and cells of a second type for which a specific gene is under the control of a promoter which is regulated by the separated signal molecule, in such a way that the secretion of the signal molecule is induced by a primary signal taken up by a cell of the first type, and the primary signal is amplified by the cells of the second type by the expression of the specific gene under the control of the signal molecule.

摘要翻译： 本发明涉及利用细胞内通信系统检测和扩增主要信号的装置和方法及其用于检测磷，硫，氮，激素，代谢中间体，发酵产物等物质的用途， 等等。 用于检测和扩增主要信号的根据本发明的装置包含第一类型的细胞，其中负责合成信号分子的基因处于由初级细胞调节的启动子的控制之下 信号和第二类型的细胞，其中特定基因处于由分离的信号分子调节的启动子的控制下，使得信号分子的分泌是由主要信号诱导的， 第一类型的细胞，并且通过在信号分子的控制下的特定基因的表达，第一类型的细胞被第二类型的细胞扩增。

公开(公告)号：US20070090371A1

公开(公告)日：2007-04-26

申请号：US10549775

申请日：2004-03-19

申请人： Jens Drechsel ,  Martin Pfeiffer ,  Bert Maennig ,  Karl Leo

发明人： Jens Drechsel ,  Martin Pfeiffer ,  Bert Maennig ,  Karl Leo

IPC分类号： H01L33/00

CPC分类号： H01L51/424 ,  B82Y10/00 ,  H01L27/302 ,  H01L51/002 ,  H01L51/0046 ,  H01L51/0059 ,  H01L51/0078 ,  H01L51/0092 ,  H01L51/4253 ,  H01L51/4293 ,  H01L2251/308 ,  Y02E10/549

摘要： The invention relates to a photoactive component, especially a solar cell, comprising organic layers and formed by at least one stacked pi, ni, and/or pin diode. The diodes are characterised in that they comprise at least one p-doped or n-doped transport layer having a larger optical band gap than that of the photoactive layer. The individual diodes are characterised by a high internal quantum yield, but can be optically thin (peak absorption

摘要翻译： 本发明涉及一种光活性组分，特别是太阳能电池，其包含有机层并由至少一个层叠的pI，ni和/或pin二极管形成。 二极管的特征在于它们包括至少一个具有比光活性层的光学带隙更大的光学带隙的p掺杂或n掺杂的传输层。 各个二极管的特征在于高的内部量子产率，但是可以是光学薄的（峰值吸收<80％）。 通过使用光阱放大二极管中的入射光的光路，或者通过堆叠多个二极管来获得高的外部量子产率。 为了改善复合和产生的目的，由过渡层促进两个二极管之间的转变。 使用具有大带隙的掺杂传输层，两种形式的实施例具有许多具体优点。

公开(公告)号：US07065413B2

公开(公告)日：2006-06-20

申请号：US10009010

申请日：2001-04-03

申请人： Volker Moebius ,  Knut Grossmann

发明人： Volker Moebius ,  Knut Grossmann

IPC分类号： G05B11/01

CPC分类号： G05B19/056 ,  G05B19/0426 ,  G05B2219/1171 ,  G05B2219/13091 ,  G05B2219/13099

摘要： In a method for controlling mechanisms or technical systems, the mechanisms or technical systems to be controlled are stored in a controller with their states, and with associated signal formers of sensors and actuators, whereby starting from a defined reference state at the onset of the activation of the controller, the actual states signaled by the technical system via the sensors are continuously compared with the specified state, the specified state being stored in the controller, and, based on this comparison, every deviation from the specified state is identified in the technical system, and, when initiated, a new instruction that changes the state of the mechanisms or of the technical system updates the specified state for the comparison and monitors the time till the acknowledgment of the new state, and sensor signals and comparable information exclusively serve the state identification of elementary functions and state changes exclusively ensue upon the initiation of elementary instructions.

摘要翻译： 在用于控制机构或技术系统的方法中，要控制的机构或技术系统被存储在具有其状态的控制器中，并且与传感器和致动器的相关联的信号形成器一起存储，从而在激活开始时从限定的参考状态开始 控制器的技术系统通过传感器发出的实际状态与指定状态持续进行比较，指定状态存储在控制器中，并且基于该比较，在技术上识别出与指定状态的每一偏差 系统，并且当发起时，改变机制或技术系统的状态的新指令更新用于比较的指定状态，并且监视直到新状态的确认的时间，并且传感器信号和可比信息专门用于 基本功能和状态变化的状态识别仅在元素启动时发生 y说明。

公开(公告)号：US6106480A

公开(公告)日：2000-08-22

申请号：US269458

申请日：1999-04-23

申请人： Marcelo Gama De Abreu ,  Detlev Michael Albrecht

发明人： Marcelo Gama De Abreu ,  Detlev Michael Albrecht

IPC分类号： A61B5/026 ,  A61B5/029 ,  A61B5/08

CPC分类号： A61B5/029

摘要： The invention relates to a device to determine effective pulmonary blood flow (PBF) by means of partial CO.sub.2 rebreathing. The device is characterized in that it comprises an endotracheal tube whose conduit leading from the patient to the respirator is divided up into two lanes between a controllable three-way valve (4) and a Y-piece; one lane builds a larger dead area (6) for CO.sub.2 rebreathing whereby, in order to measure CO.sub.2 elimination and end expiratory partial CO.sub.2 pressure a CO.sub.2 sensor (3) and a respiration flow sensor (1) are provided on the endotracheal tube of the patient. The calculation of effective pulmonary blood flow is provided by a microprocessor/controller (7) which also controls the three-way valve (4) which provides the switching between both lanes.

摘要翻译： PCT No.PCT / DE97 / 02194 Sec。 371日期1999年4月23日第 102（e）1999年4月23日PCT PCT 1997年9月26日PCT公布。 公开号WO98 / 12963 日期1998年4月2日本发明涉及通过部分二氧化碳再呼吸来确定有效肺血流量（PBF）的装置。 该装置的特征在于其包括气管插管，其中从患者导向呼吸器的导管在可控三通阀（4）和Y形件之间分成两个通道; 一个通道建立更大的死区（6），用于二氧化碳再呼吸，为了测量二氧化碳消除和终点呼气部分二氧化碳压力，在患者的气管内管上提供CO 2传感器（3）和呼吸流量传感器（1） 。 有效肺血流量的计算由微处理器/控制器（7）提供，微处理器/控制器（7）还控制提供两通道之间切换的三通阀（4）。

公开(公告)号：US5749800A

公开(公告)日：1998-05-12

申请号：US652557

申请日：1996-06-06

申请人： Thomas Nagel ,  Ulf Richard

发明人： Thomas Nagel ,  Ulf Richard

IPC分类号： F16H7/02 ,  F16H9/26 ,  F16H19/06

CPC分类号： F16H9/26 ,  F16H19/005 ,  F16H19/06 ,  F16H2019/0609

摘要： A synchronous belt drive, with a high multiplication ratio for transforming a rotary movement into a translation or rotary movement, has at least two rows of teeth with different pitches interconnected by a toothed belt. The rows of teeth with different pitches engage wheels of at least one pair of wheels secured against independent rotation. The products of the number of teeth of the wheels and the pitch of the corresponding row of teeth differ at least slightly from each other. The pitch difference between the toothed belts gives the drive a high multiplication ratio. Very fine gradations and therefore high multiplication ratios may be achieved, even when the tooth modulus is high for reasons of resistance.

摘要翻译： PCT No.PCT / DE94 / 01445 Sec。 371日期：1996年6月6日 102（e）1996年6月6日PCT 1994年12月6日PCT PCT。 公开号WO95 / 16152 PCT 日期1995年6月15日具有用于将旋转运动转换为平移或旋转运动的高倍率的同步带传动具有至少两排具有不同节距的齿，其齿距通过齿形带相互连接。 具有不同间距的齿排与至少一对固定在独立旋转上的轮对啮合。 轮的齿数和相应行齿的间距的产物彼此至少略微不同。 齿形带之间的间距差使驱动器具有高倍增比。 即使由于电阻而导致的齿模高，也可以实现非常细的等级，因此可以实现高的倍率。

公开(公告)号：US5720792A

公开(公告)日：1998-02-24

申请号：US525571

申请日：1996-02-16

申请人： Klaus Fischer ,  Joachim Katzur ,  Rainer Schiene

发明人： Klaus Fischer ,  Joachim Katzur ,  Rainer Schiene

IPC分类号： C05F7/02 ,  C05C11/00 ,  C05F11/02

CPC分类号： C05F11/02 ,  C05C11/00

摘要： The invention concerns a high-grade, long-duration, organic fertilizer and a method of manufacturing it by the oxidative ammonolysis of industrial lignin. The fertilizer contains nitrogen in the form of ammonium compounds, normally hydrolyzable amides and more strongly bound organic nitrogen. The proportion of more strongly bound organic nitrogen is 55 to 85%, preferably 65 to 80%, relative to the total nitrogen content of the fertilizer. The manufacturing process uses industrial lignin precipitated under alkaline conditions from alkaline waste liquors, extracts or solutions. Preliminary tests have confirmed that this process gives a natural-like, high-grade, long-duration fertilizer similar to humus in character and with surprisingly good environmental compatibility.

摘要翻译： PCT No.PCT / DE94 / 00310 Sec。 371日期1996年2月16日 102（e）日期1996年2月16日PCT 1994年3月18日PCT公布。 公开号WO94 / 21576 日期1994年9月29日本发明涉及高品位，长期有机肥料及其通过工业木质素的氧化氨解制造方法。 肥料含有铵化合物形式的氮，通常是可水解的酰胺和更强的结合有机氮。 较强结合有机氮的比例相对于肥料的总氮含量为55〜85％，优选为65〜80％。 制造过程使用在碱性条件下从碱性废液，提取物或溶液中沉淀的工业木质素。 初步测试证实，该方法产生类似于腐殖质的天然样，高等级，长期肥料，具有令人惊奇的良好的环境兼容性。

公开(公告)号：US11851693B2

公开(公告)日：2023-12-26

申请号：US17276820

申请日：2019-11-04

申请人： TECHNISCHE UNIVERSITAET DRESDEN

发明人： Susanne Steudler ,  Stephanie Stange ,  Hubertus Delenk ,  Andre Wagenfuehr ,  Christof Zeeb ,  Thomas Walther

IPC分类号： C12P17/18 ,  C12N1/14 ,  C12R1/645

CPC分类号： C12P17/181 ,  C12N1/145 ,  C12R2001/645

摘要： The invention relates to a method for the biotechnological production of the blue-green fungus pigment xylindein from fungus biomass in a bioreactor, the reactor contents being inoculated with biomass that is uncoloured.
The invention also relates to the use of uncoloured biomass of the fungus culture Chlorociboria sp. for inoculation in the biotechnological production of the blue-green fungus pigment xylindein.

公开(公告)号：US11668961B2

公开(公告)日：2023-06-06

申请号：US16355424

申请日：2019-03-15

申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V. ,  Technische Universitaet Dresden

发明人： Joerg Heber ,  Matthias Roth ,  Klaus Janschek

IPC分类号： G02F1/01 ,  G02F1/1333 ,  G02B26/06 ,  G02B27/46 ,  G02F1/13

CPC分类号： G02F1/01 ,  G02B26/06 ,  G02B27/46 ,  G02F1/1333 ,  G02F1/1313 ,  G02F2203/12 ,  G02F2203/50 ,  G03H2223/13 ,  G03H2225/30 ,  G03H2225/55

摘要： A phase and phase/amplitude spatial light modulator arrangement for generating a complex-valued light field with a spatial light modulator, a phase element and an optical system. The phase and amplitude spatial light modulator arrangement is configured to generate a light field that is adjustable in amount and phase.
A method realizes operation of a combined spatial light modulator for generating a complex-valued light field. Here, the method includes adapting an optical characteristic in several areas of a phase element.
A further method realizes operation of an optical arrangement for modulating different light wavelengths by adjusting several wave influences in several areas of a phase modulator.
A last method realizes operation of an optical arrangement by adjusting an amplitude spatial light modulator for modulating light intensities in at least two optical paths.

公开(公告)号：US11594741B2

公开(公告)日：2023-02-28

申请号：US17292508

申请日：2019-11-05

申请人： FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  TECHNISCHE UNIVERSITAET DRESDEN

发明人： Eckhard Beyer ,  Teja Roch

IPC分类号： H01M8/0228 ,  H01M8/0206 ,  H01M8/0213 ,  H01M8/0258 ,  H01M8/0297

摘要： A method for producing bipolar plates for fuel cells, one metal strip or two metal strips is/are guided through a second or third device. The second device is designed to carry out fine cleaning and/or nitriding of the metal strip, and the third device carries out surface coating on one side of a surface with a metal layer that improves adhesion. Applying a carbon layer in a fourth device. The metal strips are then shaped, during which process channels are formed. The shaped metal strips are moved and positioned such that surface regions come into contact with one another. Joining is performed with a laser beam, which is directed into a gap between the shaped metal strips moved towards one another. The individual steps in the devices, like shaping and joining, are carried out in a continuous process.