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公开(公告)号：US20230352203A1
公开(公告)日：2023-11-02
申请号：US18213194
申请日：2023-06-22
Applicant: Curium US LLC
Inventor： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC classification number: G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US11195633B2
公开(公告)日：2021-12-07
申请号：US16325862
申请日：2017-08-14
Applicant: Curium US LLC
Inventor： Luis Antonio M. M. Barbosa
Abstract: Gallium-68 generators that are capable of producing gallium-68 from a germanium-68 source material are disclosed. The source material may be a matrix material (e.g., zeolite) in which germanium-68 is isomorphously substituted for central atoms in tetrahedra within the matrix material. Methods for forming gallium-68 generators are also disclosed.
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公开(公告)号：US10710885B2
公开(公告)日：2020-07-14
申请号：US16325891
申请日：2017-08-14
Applicant: Curium US LLC
Inventor： Luis Antonio M. M. Barbosa
IPC: C01B37/02 , G01T1/29 , G01T7/00 , C01G17/02 , G01T1/169 , A61B6/00 , C01G17/00 , A61B6/03 , H01L31/00 , B01J29/04
Abstract: Calibration devices including germanium-68 source material are disclosed. The source material may be a matrix material (e.g., zeolite) in which germanium-68 is isomorphously substituted for central atoms in tetrahedra within the matrix material. Methods for preparing such calibration devices are also disclosed.
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Patent Agency Ranking
公开(公告)号：US10688209B2
公开(公告)日：2020-06-23
申请号：US15411381
申请日：2017-01-20
Applicant: Curium US LLC
Inventor： John Schmitz , Michael J. D'Hooge , Andrew M. Schadt , Gregory Bengard , Sumit Verma , Kevin B. Graves , Bryan S. Petrofsky
Abstract: A system includes a radiation containment chamber, an isolator connected to the radiation containment chamber, a rotating transfer door positioned between the radiation containment chamber and the isolator, and an antimicrobial vapor generator connected to the isolator. The rotating transfer door includes a cavity for receiving a radionuclide generator column assembly, and is rotatable between a first position, in which the cavity is open to the radiation containment chamber, and a second position, in which the cavity is open to the isolator. The transfer door is adapted to rotate while antimicrobial vapor is introduced into the isolator by the antimicrobial vapor generator.
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公开(公告)号：US10578094B2
公开(公告)日：2020-03-03
申请号：US15394272
申请日：2016-12-29
Applicant: Curium US LLC
Inventor： Martin R. Walker , Ryan W. Lenger , Kevin B. Graves , Bryan S. Petrofsky
Abstract: A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. The system also includes a pump within the enclosure for transferring fluid through tubing. The pump includes a pump head including a casing, a rotor that rotates in relation to the casing, and a clamp. The tubing extends through the pump head. The clamp compresses the tubing against the rotor and directs radioactive fluid through the tubing as the rotor rotates. The pump also includes a servomotor that controls the rotation of the rotor and a coupling connecting the pump head to the servomotor. The coupling prevents backlash between the servomotor and the rotor during rotation.
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公开(公告)号：US10406252B2
公开(公告)日：2019-09-10
申请号：US15410017
申请日：2017-01-19
Applicant: Curium US LLC
Inventor： Kevin B. Graves , Bryan S. Petrofsky , Sumit Verma , John Schmitz , Michael J. D'Hooge
Abstract: A system for manufacturing radionuclide generators including an enclosure defining a radioactive environment, at least one autoclave sterilizer within the enclosure, and at least two loading and unloading elevators. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. Each autoclave sterilizer includes a plurality of sterilization stations arranged vertically and at least two autoclave rails. One loading and unloading elevator is configured to load a cart into the autoclave sterilizer and one loading and unloading elevator is configured to unload the cart from the autoclave sterilizer. Each loading and unloading elevator includes at least two cart rails configured to support the cart and a plurality of loading elevator rails coupled to the cart rails. The loading elevator rails are configured to adjust the height of the cart rails.
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公开(公告)号：US10399023B2
公开(公告)日：2019-09-03
申请号：US15408932
申请日：2017-01-18
Applicant: Curium US LLC
Inventor： Sumit Verma , Bryan S. Petrofsky , Kevin B. Graves , Donald W. Reese
Abstract: An air distribution system for supplying filtered air to isolator working volumes includes an inlet including a HEPA filter and an outlet including a slidably mounted sintered panel. Methods for supplying filtered air to an isolator working volume are also disclosed.
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公开(公告)号：US20190206584A1
公开(公告)日：2019-07-04
申请号：US16325245
申请日：2017-08-14
Applicant: Curium US LLC
Inventor： Arend Booij
IPC: G21G1/00
CPC classification number: G21G1/001 , G21G2001/0036 , G21G2001/0094
Abstract: The present disclosure provides a method of separating Mo-99 from W-187 from a solution comprising Mo-99 and W-187. The method comprises contacting a tridentate diglycolanude ligand with a solution comprising Mo-99 and W-187 and eluting W-187 from the tridentate diglycolanude ligand to thereby an eluate comprising W-187.
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