公开(公告)号：US07173023B2

公开(公告)日：2007-02-06

申请号：US10967567

申请日：2004-10-18

Applicant: Synese Jolidon ,  Rosa Maria Rodriguez Sarmiento ,  Andrew William Thomas ,  Wolfgang Wostl ,  Rene Wyler

Inventor： Synese Jolidon ,  Rosa Maria Rodriguez Sarmiento ,  Andrew William Thomas ,  Wolfgang Wostl ,  Rene Wyler

IPC: A61K31/55 ,  C07D223/16 ,  C07D487/02

CPC classification number: C07D223/16

Abstract: The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X′, Y and Y′ are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.

Abstract translation: 本发明涉及下式的新型苯并氮杂衍生物：其中R 1，R 2，R 3，R 4， / SUP>和R 5，X，X'，Y和Y'如说明书和权利要求书中所定义，其制备方法，含有所述衍生物的药物组合物及其用于制备药物的用途 可用于预防和治疗单胺氧化酶B活性的选择性抑制发挥作用或牵连的疾病。

公开(公告)号：US06903095B2

公开(公告)日：2005-06-07

申请号：US10657857

申请日：2003-09-09

Applicant: Andrea Cesura ,  Rosa Maria Rodriguez Sarmiento ,  Andrew William Thomas ,  Rene Wyler

Inventor： Andrea Cesura ,  Rosa Maria Rodriguez Sarmiento ,  Andrew William Thomas ,  Rene Wyler

IPC: A61K31/4035 ,  A61K31/42 ,  A61K31/437 ,  A61K31/454 ,  A61K31/5377 ,  A61P25/28 ,  A61P43/00 ,  C07D209/48 ,  C07D401/04 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D471/04 ,  A61K31/535 ,  C07D413/00

CPC classification number: C07D209/48 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04

Abstract: This invention relates to phthalimido derivatives of the formula wherein X is —N═ or —CH═, and R1 to R4 and m are as defined in the specification, as well as their pharmaceutically acceptable salts. The invention further relates to pharmaceutical compositions containing these compounds, a method of treating a disease by administering a therapeutically effective amount of at least one of these compounds, and a process for their preparation for the treatment or prevention of diseases in which MAO-B inhibitors might be beneficial.

Abstract translation: 本发明涉及下式的邻苯二甲酰亚氨基衍生物其中X是-N-或-CH-，R 1至R 4和m如说明书中所定义，如 以及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，通过施用治疗有效量的这些化合物中的至少一种来治疗疾病的方法及其制备治疗或预防MAO-B抑制剂 可能是有益的

公开(公告)号：US06042379A

公开(公告)日：2000-03-28

申请号：US234647

申请日：1999-01-21

Applicant: Jose Maria Rodriguez del Val

Inventor： Jose Maria Rodriguez del Val

IPC: A61C3/14

CPC classification number: A61C3/14

Abstract: Dental raising forceps for the posterior upper molars or their remains, in the upper arcade, which has a passive part (1) and a hinge (2) that are conventional, together with a contra-angled part in bayonet form (3), and which terminates in certain moving jaws (4), in a circumferential arch, concave on the inside and symmetrical, and the cross-section of which gradually diminishes until it terminates in two points, (assuming the shape of a pair of bull's horns) which makes it possible to insert it between the last two dental pieces and which when it is moved gives rise to the distal (backwards) luxation of the last molar and its consequent loosening.

Abstract translation: 在上部拱廊中的上部上臼齿或其遗留物的颚式镊子，其具有常规的被动部分（1）和铰链（2）以及卡口形式（3）的对角部分，以及 其在某些移动的夹爪（4）中终止于周向拱形，内部凹陷并且对称，并且其横截面逐渐减小，直到其终止于两点（假设一对公牛角的形状），其中 使其可以插入到最后两个牙齿片之间，并且当它被移动时，会产生最后一个摩擦的远端（向后）摩擦并随之而来的松动。

公开(公告)号：US2822140A

公开(公告)日：1958-02-04

申请号：US49084655

申请日：1955-02-28

Applicant: MARIA RODRIGUEZ PEDRO

Inventor： MARIA RODRIGUEZ PEDRO

IPC: A63H27/08

CPC classification number: A63H27/08

公开(公告)号：US09187455B2

公开(公告)日：2015-11-17

申请号：US12705988

申请日：2010-02-16

Applicant: Daniela Alberati ,  Matthias Koerner ,  Bernd Kuhn ,  Jens-Uwe Peters ,  Rosa Maria Rodriguez Sarmiento ,  Mark Rogers-Evans ,  Markus Rudolph

Inventor： Daniela Alberati ,  Matthias Koerner ,  Bernd Kuhn ,  Jens-Uwe Peters ,  Rosa Maria Rodriguez Sarmiento ,  Mark Rogers-Evans ,  Markus Rudolph

IPC: A61K31/501 ,  C07D237/04 ,  C07D403/14

CPC classification number: C07D403/14

Abstract: The present invention is concerned with novel pyridazinone derivatives of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

Abstract translation: 本发明涉及式（I）的新的哒嗪酮衍生物，其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物抑制PDE10A，可用作药物。

公开(公告)号：US08623866B2

公开(公告)日：2014-01-07

申请号：US13151301

申请日：2011-06-02

Applicant: Konrad Bleicher ,  Alexander Flohr ,  Katrin Groebke Zbinden ,  Felix Gruber ,  Matthias Koerner ,  Bernd Kuhn ,  Jens-Uwe Peters ,  Rosa Maria Rodriguez-Sarmiento

Inventor： Konrad Bleicher ,  Alexander Flohr ,  Katrin Groebke Zbinden ,  Felix Gruber ,  Matthias Koerner ,  Bernd Kuhn ,  Jens-Uwe Peters ,  Rosa Maria Rodriguez-Sarmiento

IPC: C07D239/42 ,  A01N43/54 ,  A61K31/5355 ,  C07D403/14 ,  A61K31/497 ,  A61P25/18

Abstract: The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1, R2, R3, R4, R5 and R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as therapeutics.

公开(公告)号：US08586579B2

公开(公告)日：2013-11-19

申请号：US13161548

申请日：2011-06-16

Applicant: Luca Gobbi ,  Rosa Maria Rodriguez Sarmiento ,  Juergen Wichmann

Inventor： Luca Gobbi ,  Rosa Maria Rodriguez Sarmiento ,  Juergen Wichmann

IPC: A61K31/496 ,  C07D491/04 ,  C07D495/04

CPC classification number: C07D491/048 ,  C07D495/04

Abstract: The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein X, Y, A, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as therapeutics.

公开(公告)号：US08415350B2

公开(公告)日：2013-04-09

申请号：US13233056

申请日：2011-09-15

Applicant: Luca Gobbi ,  Georg Jaeschke ,  Thomas Luebbers ,  Olivier Roche ,  Rosa Maria Rodriguez-Sarmiento ,  Lucinda Steward

Inventor： Luca Gobbi ,  Georg Jaeschke ,  Thomas Luebbers ,  Olivier Roche ,  Rosa Maria Rodriguez-Sarmiento ,  Lucinda Steward

IPC: A61K31/496 ,  A61K31/5377 ,  C07D401/08 ,  C07D417/08

CPC classification number: C07D401/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.

Abstract translation: 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。

公开(公告)号：US20120283254A1

公开(公告)日：2012-11-08

申请号：US13457532

申请日：2012-04-27

Applicant: Rosa Maria Rodriguez Sarmiento ,  Juergen Wichmann

Inventor： Rosa Maria Rodriguez Sarmiento ,  Juergen Wichmann

IPC: A61K31/4525 ,  C07D413/14 ,  C07D405/14 ,  C07D417/14 ,  A61K31/5377 ,  A61K31/4709 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/541 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22 ,  A61P25/30 ,  A61P25/00 ,  A61P25/28 ,  C07D405/04

CPC classification number: A61K31/343 ,  A61K31/4525 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention is concerned with novel selective dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein R1, R2, R3, n, and Y are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as pharmaceuticals.

Abstract translation: 本发明涉及式（I）的5-HT2A和D3受体的新型选择性双重调节剂，其中R 1，R 2，R 3，n和Y如本文所述，以及其药学上可接受的盐和酯。 此外，本发明涉及制备式（I）化合物，包含它们的药物组合物及其作为药物的用途。

公开(公告)号：US08039490B2

公开(公告)日：2011-10-18

申请号：US11705635

申请日：2007-02-13

Applicant: Luca Gobbi ,  Georg Jaeschke ,  Thomas Luebbers ,  Olivier Roche ,  Rosa Maria Rodriguez Sarmiento ,  Lucinda Steward

Inventor： Luca Gobbi ,  Georg Jaeschke ,  Thomas Luebbers ,  Olivier Roche ,  Rosa Maria Rodriguez Sarmiento ,  Lucinda Steward

IPC: A61K31/445 ,  C07D211/32

CPC classification number: C07D401/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.

Abstract translation: 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。