公开(公告)号：US11474296B2

公开(公告)日：2022-10-18

申请号：US17268489

申请日：2019-08-07

Applicant: Soreq Nuclear Research Center ,  Ramot at Tel Aviv University

Inventor： Shiomi Lightman ,  Gilad Hurvitz ,  Razi Gvishi ,  Ady Arie

IPC: G02B6/26 ,  G02B6/24 ,  G02B6/25

Abstract: A fiber mode sorter includes an optical fiber including a waveguide structure configured to maintain an orbital angular momentum (OAM) of a beam propagating through the optical fiber, and an OAM mode sorter placed on a core of the optical fiber.

公开(公告)号：US20220281960A1

公开(公告)日：2022-09-08

申请号：US17627167

申请日：2019-07-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Natalia FREUND ,  Ronen WEISS

IPC: C07K16/12 ,  A61P31/06 ,  C12P21/00 ,  C12N1/20 ,  C12N15/70 ,  G01N33/569

Abstract: A human antibody comprising an antigen binding domain which binds PstS1 of Mycobacterium tuberculosis (TB) for use in preventing or treating TB infection in a subject in need thereof is provided. Also provided are vaccine compositions and conjugates of such antibodies.

公开(公告)号：US11427531B2

公开(公告)日：2022-08-30

申请号：US16754386

申请日：2018-10-09

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Asher Peretz ,  Bernard Attali

IPC: C07C233/22 ,  C07C237/20 ,  A61K31/165 ,  A61P25/02 ,  A61P43/00

Abstract: Novel compounds usable in modulating an activity or function of a voltage-dependent potassium channel and/or of TRPV1 are provided. The compounds are represented by Formula I as described and defined in the specification.

公开(公告)号：US20220265570A1

公开(公告)日：2022-08-25

申请号：US17611093

申请日：2020-05-17

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： David Meiri ,  Elazar Besser ,  Igal Louria-Hayon ,  Paula Berman ,  Gil Moshe Lewitus ,  Limor Broday

IPC: A61K31/05 ,  A61P35/00

Abstract: The present invention provides a pharmaceutical composition including a combination of at least two cannabinoids, and methods of using same, such as for treating a NOTCH 1-related disease.

公开(公告)号：US11386507B2

公开(公告)日：2022-07-12

申请号：US16579454

申请日：2019-09-23

Applicant: International Business Machines Corporation ,  TRUSTEES OF TUFTS COLLEGE ,  Ramot at Tel-Aviv University Ltd.

Inventor： Lior Horesh ,  Osman Asif Malik ,  Shashanka Ubaru ,  Misha E. Kilmer ,  Haim Avron

IPC: G06Q50/00 ,  G06F17/16 ,  G06N20/00 ,  G06F16/901

Abstract: A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.

公开(公告)号：US11375939B2

公开(公告)日：2022-07-05

申请号：US16316627

申请日：2017-07-12

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Alex Bronstein ,  Evgeny Tsizin-Goldman

IPC: A61B5/30 ,  A61B5/00 ,  A61N1/36 ,  A61B5/0531 ,  A61N1/04 ,  A61B5/1495 ,  A61N1/08 ,  G06F3/01 ,  A61N1/378 ,  A61B5/291 ,  A61B5/296 ,  A61B5/316 ,  A61B5/369 ,  A61B5/389 ,  A61B5/24

Abstract: Apparatus, including a set of N electrodes (22), configured to be located in proximity to an epidermis (24) of a subject, and to acquire signals generated by electric sources within the subject. The apparatus also includes a set of M channels, configured to transfer the signals, where M is less than N, and a switch (40), configured to select, repetitively and randomly, M signals from the N electrodes and to direct the M signals to the M channels. The apparatus further includes a processor (28), configured to activate the switch, and to receive and analyze the M signals from the M channels so as to determine respective positions of the electric sources within the subject.

公开(公告)号：US20220183872A1

公开(公告)日：2022-06-16

申请号：US17310713

申请日：2020-02-18

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Amit GEFEN

IPC: A61F5/32 ,  A61F7/02 ,  A61M35/00 ,  A61F5/34 ,  B29C39/12

Abstract: Provided is a patch including at least one pressure-absorbing member, the pressure absorbing member formed of a resilient material and having at least a first surface, the at least first surface is configured with a plurality of projections extending therefrom and a plurality of channels crossing one another at a plurality of intersections, an outermost surface of said plurality of projections lies along a projections plane of the pressure-absorbing member, the projections being deformable when subjected to pressure applied to the patch, so as to absorb at least some of the applied pressure.

公开(公告)号：US11360173B2

公开(公告)日：2022-06-14

申请号：US17318123

申请日：2021-05-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Noam Ben-Eliezer ,  Natalie Bnaiahu

IPC: G01R33/50 ,  G01R33/561 ,  G01R33/56 ,  G01R33/563

Abstract: A method of mapping transverse relaxation in a magnetic resonance (MR) scan data, comprises receiving a multi-echo spin-echo MR scan protocol comprising a plurality of MR imaging parameters, and for each echo of the multi-echo spin-echo MR scan protocol: generating, based on the parameters, a simulated echo modulation curve using a set of refocusing coherence pathways, for each of a plurality of predetermined transverse relaxation times; calculating, for each transverse relaxation time, diffusion attenuation based on a respective subset of the refocusing coherence pathways; and correcting the echo modulation curve using the diffusion attenuation. The method can also comprise comparing the scan data to the corrected echo modulation curve for each of at least a portion of the transverse relaxation values, and generating a displayed output comprising a map of transverse relaxation based on the comparison.

公开(公告)号：US20220135969A1

公开(公告)日：2022-05-05

申请号：US17436167

申请日：2020-03-04

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Assaf ZEMACH ,  Nir OHAD ,  Rafael YAARI ,  Aviva KATZ ,  Katherine DOMB

IPC: C12N15/11 ,  C12N9/22 ,  C12N9/10 ,  A01H11/00

Abstract: An isolated polynucleotide encoding a fusion protein which comprises a DNA targeting moiety linked to a catalytic domain of a plant DNA methyltransferase 3 (DNMT3) protein is disclosed. Uses thereof are also disclosed.

公开(公告)号：US20220119339A1

公开(公告)日：2022-04-21

申请号：US17452970

申请日：2021-10-29

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Yoram Cohen ,  Micha Fridman ,  Roymon Joseph ,  Alissa Naugolny ,  Mark Feldman ,  Ido M. Herzog ,  Dana Kaizerman

IPC: C07C217/54 ,  A61K31/138 ,  A61K31/4178 ,  A61K31/66 ,  A61K45/06 ,  C02F1/50 ,  C07D233/60 ,  C07F9/54 ,  C09D5/16

Abstract: Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.