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公开(公告)号：US11427531B2
公开(公告)日：2022-08-30
申请号：US16754386
申请日：2018-10-09
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Asher Peretz , Bernard Attali
IPC: C07C233/22 , C07C237/20 , A61K31/165 , A61P25/02 , A61P43/00
Abstract: Novel compounds usable in modulating an activity or function of a voltage-dependent potassium channel and/or of TRPV1 are provided. The compounds are represented by Formula I as described and defined in the specification.
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公开(公告)号：US20220265570A1
公开(公告)日：2022-08-25
申请号：US17611093
申请日：2020-05-17
Inventor： David Meiri , Elazar Besser , Igal Louria-Hayon , Paula Berman , Gil Moshe Lewitus , Limor Broday
Abstract: The present invention provides a pharmaceutical composition including a combination of at least two cannabinoids, and methods of using same, such as for treating a NOTCH 1-related disease.
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公开(公告)号：US11386507B2
公开(公告)日：2022-07-12
申请号：US16579454
申请日：2019-09-23
Applicant: International Business Machines Corporation , TRUSTEES OF TUFTS COLLEGE , Ramot at Tel-Aviv University Ltd.
Inventor： Lior Horesh , Osman Asif Malik , Shashanka Ubaru , Misha E. Kilmer , Haim Avron
IPC: G06Q50/00 , G06F17/16 , G06N20/00 , G06F16/901
Abstract: A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.
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公开(公告)号：US11375939B2
公开(公告)日：2022-07-05
申请号：US16316627
申请日：2017-07-12
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Alex Bronstein , Evgeny Tsizin-Goldman
IPC: A61B5/30 , A61B5/00 , A61N1/36 , A61B5/0531 , A61N1/04 , A61B5/1495 , A61N1/08 , G06F3/01 , A61N1/378 , A61B5/291 , A61B5/296 , A61B5/316 , A61B5/369 , A61B5/389 , A61B5/24
Abstract: Apparatus, including a set of N electrodes (22), configured to be located in proximity to an epidermis (24) of a subject, and to acquire signals generated by electric sources within the subject. The apparatus also includes a set of M channels, configured to transfer the signals, where M is less than N, and a switch (40), configured to select, repetitively and randomly, M signals from the N electrodes and to direct the M signals to the M channels. The apparatus further includes a processor (28), configured to activate the switch, and to receive and analyze the M signals from the M channels so as to determine respective positions of the electric sources within the subject.
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公开(公告)号：US20220183872A1
公开(公告)日：2022-06-16
申请号：US17310713
申请日：2020-02-18
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Amit GEFEN
Abstract: Provided is a patch including at least one pressure-absorbing member, the pressure absorbing member formed of a resilient material and having at least a first surface, the at least first surface is configured with a plurality of projections extending therefrom and a plurality of channels crossing one another at a plurality of intersections, an outermost surface of said plurality of projections lies along a projections plane of the pressure-absorbing member, the projections being deformable when subjected to pressure applied to the patch, so as to absorb at least some of the applied pressure.
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Patent Agency Ranking
公开(公告)号：US11360173B2
公开(公告)日：2022-06-14
申请号：US17318123
申请日：2021-05-12
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Noam Ben-Eliezer , Natalie Bnaiahu
IPC: G01R33/50 , G01R33/561 , G01R33/56 , G01R33/563
Abstract: A method of mapping transverse relaxation in a magnetic resonance (MR) scan data, comprises receiving a multi-echo spin-echo MR scan protocol comprising a plurality of MR imaging parameters, and for each echo of the multi-echo spin-echo MR scan protocol: generating, based on the parameters, a simulated echo modulation curve using a set of refocusing coherence pathways, for each of a plurality of predetermined transverse relaxation times; calculating, for each transverse relaxation time, diffusion attenuation based on a respective subset of the refocusing coherence pathways; and correcting the echo modulation curve using the diffusion attenuation. The method can also comprise comparing the scan data to the corrected echo modulation curve for each of at least a portion of the transverse relaxation values, and generating a displayed output comprising a map of transverse relaxation based on the comparison.
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公开(公告)号：US20220135969A1
公开(公告)日：2022-05-05
申请号：US17436167
申请日：2020-03-04
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Assaf ZEMACH , Nir OHAD , Rafael YAARI , Aviva KATZ , Katherine DOMB
Abstract: An isolated polynucleotide encoding a fusion protein which comprises a DNA targeting moiety linked to a catalytic domain of a plant DNA methyltransferase 3 (DNMT3) protein is disclosed. Uses thereof are also disclosed.
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公开(公告)号：US20220119339A1
公开(公告)日：2022-04-21
申请号：US17452970
申请日：2021-10-29
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman
IPC: C07C217/54 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06 , C02F1/50 , C07D233/60 , C07F9/54 , C09D5/16
Abstract: Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.
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公开(公告)号：US20220111029A1
公开(公告)日：2022-04-14
申请号：US17418977
申请日：2019-12-27
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit SATCHI-FAINARO , Helena FLORINDO , Joao CONNIOT , Anna SCOMPARIN
IPC: A61K39/00 , A61K31/7105 , A61K31/711 , A61K39/395 , A61K45/06 , A61K47/69 , A61K39/39 , A61P35/00
Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle; (ii) at least one adjuvant; and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.
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公开(公告)号：US20220107991A1
公开(公告)日：2022-04-07
申请号：US17060883
申请日：2020-10-01
Inventor： Shashanka Ubaru , Vasileios Kalantzis , Lior Horesh , Mark S. Squillante , Haim Avron
Abstract: A method of performing Principal Component Analysis is provided. The method includes receiving, by a computing device, evolving data for processing/visualization. The method further includes, by the computing device, a dimensionality for reducing of the evolving data using the PCA, wherein the PCA is performed on analog crossbar hardware. The method also includes using, by the computing device, the evolving data for visualization having the dimensionality thereof reduced by the principal component analysis for a further application.
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