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51.发明授权公开(公告)号：US11633364B2
公开(公告)日：2023-04-25
申请号：US17337283
申请日：2021-06-02
IPC分类号： A61K9/51 , A61K9/127 , A61K31/12 , A61K31/137 , A61K31/19 , A61K31/546 , A61K31/7034 , A61K31/713 , A61K38/14 , A61K38/28 , A61K39/29 , A61K39/395 , A61K45/06
摘要： The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
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52.发明申请公开(公告)号：US20230095662A1
公开(公告)日：2023-03-30
申请号：US17652993
申请日：2022-03-01
申请人： JENTEK Sensors, Inc.
IPC分类号： G01N27/72 , B33Y50/00 , B29C64/386
摘要： Disclosed are method and apparatus for measuring material properties. Segmented field sensors have multiple sensing elements at different spatial geometries to capture field components having substantially different depths of penetration. These sensors are excited and measured on these different sensing elements to facilitate characterization of unknown material properties. This is illustrated in some embodiments using eddy current sensors to characterize materials that are frequency dispersive and/or do not produce a measurable phase shifts. Only a single scalar quantity may provide independent information from one or more of the sensing elements. Property estimation techniques, such as those using precomputed databases of sensor responses are used to estimate the unknown material properties.
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公开(公告)号：US11592496B2
公开(公告)日：2023-02-28
申请号：US16050235
申请日：2018-07-31
IPC分类号： G01R31/62 , G01K1/14 , G01K11/32 , H01F27/28 , H01F27/32 , H01F27/40 , H01F41/12 , H01F41/04 , G01K13/00
摘要： Sensing methods and systems for transformers, and the construction thereof, are described herein. Example transformer systems and example methods for constructing a core for the system are disclosed. The example system includes a core with a bottom plate, two or more limbs mounted to the bottom plate and a top plate enclosing the core. At least one of the bottom plate, the limbs and the top plate is formed with a sensing component therein. The sensing component can be mounted to a spacer layer assembled within a stack of laminated layers. The sensing component can be mounted within a path defined within the spacer layer, for example. Methods for detecting operating conditions within the transformer are also disclosed.
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公开(公告)号：US20220400937A1
公开(公告)日：2022-12-22
申请号：US17893727
申请日：2022-08-23
摘要： The present invention may be embodied as a retrievable device capable of sensing one or more properties of an individual (e.g., chemical or physical parameters). In use, the retrievable device can continuously determine the chemical concentrations within the vaginal tract. An embodiment of the retrievable device comprises a first housing having a light source and an image capture device, a second housing removably connected to the lust housing and having a sensor, and a fitting for retrieving the device. The sensor may be an analyte sensor configured to obtain at least one measurement of a concentration of an analyte in a fluid. The analyte sensor comprises a sensor substance in a sol-gel material so the sensor substance reversibly interacts with an analyte of interest. In addition, the retrievable device can be configured to determine different physical parameters and re-implanted.
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公开(公告)号：US11435217B2
公开(公告)日：2022-09-06
申请号：US17027348
申请日：2020-09-21
申请人： Gems Sensors Inc.
摘要： A tank and liquid level indicator has first housing that holds a liquid and a second elongated housing in fluid communication with the first elongated housing so that a liquid level in the second housing is approximately equal to the level in the first housing. A float in the second housing cooperates with the circuitry to operate one or more light switches. A light-transmissive cover is disposed over the light source.
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56.发明申请公开(公告)号：US20220236440A1
公开(公告)日：2022-07-28
申请号：US17649053
申请日：2022-01-26
IPC分类号： G01V3/08
摘要： Obscured feature detectors are disclosed that have both the capability to sense the location of obscured structural features and the ability to warn a user of obscured live electrical wires in the vicinity. An interleaving component, such as a MUX, can interleave the sensing of obscured features and the sensing of live wires. The interleaving component is configured to alternately couple the electrical wire sensing element to the electrical wire sensing circuitry or to the common plate separately. Coupling the live wire sensing element to the electrical wire sensing circuitry can allow sensing of a live electrical wire and coupling the live wire sensing element to a known reference signal can allow sensing of obscured features.
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公开(公告)号：US20220001414A1
公开(公告)日：2022-01-06
申请号：US17476469
申请日：2021-09-15
申请人： MATRIX SENSORS, INC.
摘要： A method is provided for coating a surface of a material with a film of porous coordination polymer. A first substrate having a first surface to be coated is positioned in a processing chamber such that the first surface is placed in an opposing relationship to a second surface. The second surface may be provided by a wall of the processing chamber, or in some cases the second surface may be provided by a second substrate to be coated. The first substrate is held such that a gap exists between the first and second surfaces, and the gap is filled with at least one reaction mixture comprising reagents sufficient to form the crystalline film on at least the first surface. A thin gap (e.g., less than 2 mm) between the first and second surfaces is effective for producing a high quality film having a thickness less than 100 μm. Confining the volume of the reaction mixture to a thin layer adjacent the substrate surface significantly reduces problems with sedimentation and concentration control. The size, shape, or average thickness of the gap may be adjusted during formation of the film in response to feedback from at least one film growth monitor.
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58.发明申请公开(公告)号：US20210387161A1
公开(公告)日：2021-12-16
申请号：US17458556
申请日：2021-08-27
申请人： Matrix Sensors, Inc.
摘要： An apparatus and method is provided for coating a surface of a substrate with at least one film of porous coordination polymer. A body has an interior space for holding the substrate to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the substrate in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the substrate in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at different, independently controllable flow rates to regulate respective concentrations of reagents in the mixture.
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公开(公告)号：US20210372968A1
公开(公告)日：2021-12-02
申请号：US17403139
申请日：2021-08-16
申请人： JENTEK Sensors, Inc.
发明人： Scott A. Denenberg , Yanko K. Sheiretov , Neil J. Goldfine , Todd M. Dunford , Andrew P. Washabaugh , Don Straney , Brian L. Manning
摘要： System and method for characterizing material condition. The system includes a sensor, impedance instrument and processing unit to collect measurements and assess material properties. A model of the system may be used to enable accurate measurements of multiple material properties. A cylindrical model for an electromagnetic field sensor is disclosed for modeling substantially cylindrically symmetric material systems. Sensor designs and data processing approaches are provided to focus the sensitivity of the sensor to localize material conditions. Improved calibration methods are shown. Sizing algorithms are provided to estimate the size of defects such as cracks and corrosion. Corrective measures are provided where the actual material configuration differs from the data processing assumptions. Methods are provided for use of the system to characterize material condition, and detailed illustration is given for corrosion, stress, weld, heat treat, and mechanical damage assessment.
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公开(公告)号：US20210278432A1
公开(公告)日：2021-09-09
申请号：US16810752
申请日：2020-03-05
IPC分类号： G01P15/03
摘要： A high precision rotation sensor comprises an inertial mass suspended from a base wherein the mass is responsive to rotational inputs that apply loads to load-sensitive resonators whose changes in resonant frequency are related to the applied loads.
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