公开(公告)号：US20230272327A1

公开(公告)日：2023-08-31

申请号：US18013200

申请日：2021-07-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： Wallace Gregory SAWYER ,  Ryan A. SMOLCHEK ,  Juan Manuel URUEÑA VARGAS ,  Jack E. FAMIGLIETTI ,  Duy T. NGUYEN

IPC: C12M1/00 ,  C12M1/12 ,  C12M1/34

CPC classification number: C12M29/10 ,  C12M25/04 ,  C12M41/40 ,  C12M23/34

Abstract: Provided herein are injection molded perfusion-enabled bioreactors and systems including said bioreactors. The bioreactor can include a lid, a frame comprising an an-ay of sample wells, a membrane adhered to a bottom of the frame beneath the array of sample wells, and a skirt adhered to a bottom of the frame, such that the membrane is located between the frame and the skirt. The skirt can include a plurality of channels corresponding to the sample wells. When the sample wells are filled with a 3D cell culture support matrix, a pressure above the 3D cell culture support matrix is atmospheric pressure and a pressure below the membrane is less than atmospheric, thereby perfusing a fluid along a vertical fluid flow path from the sample wells through the

公开(公告)号：US20230257762A1

公开(公告)日：2023-08-17

申请号：US18089975

申请日：2022-12-28

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Nian WANG

IPC: C12N15/82

CPC classification number: C12N15/8281

Abstract: The disclosure relates to a plant that is tolerant or resistant to species of Ca. Liberibacter. Specifically exemplified are citrus and solanaceous plants. Provided by the disclosure is a modified citrus or solanaceous plant that is resistant or tolerant to Sec-dependent effectors secreted by bacteria. Also provided by the disclosure are methods of modifying a plant genome plant to provide tolerance or resistance to species of Ca. Liberibacter. Still further provided by the disclosure are methods conferring a population of plants with tolerance or resistance to species of Ca. Liberibacter and screening that population for the plants that are tolerant or resistant to species of Ca. Liberibacter.

公开(公告)号：US20230255916A1

公开(公告)日：2023-08-17

申请号：US18167110

申请日：2023-02-10

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  ENTRINSIC, LLC

Inventor： Sadasivan VIDYASAGAR ,  Reshu GUPTA ,  Lianjie YIN ,  Astrid GROSCHE ,  Paul Gerson OKUNIEFF ,  Stephen J. GATTO ,  Daniel B. DENNISON

IPC: A61K31/198 ,  A61K31/405

CPC classification number: A61K31/198 ,  A61K31/405

Abstract: The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit. The present disclosure can be used to increase stem cell populations in in vivo, ex vivo and/or in vitro. Stem cell transplantation provides treatments and/or cures of many disease states, degeneration and/or injury.

公开(公告)号：US20230235924A1

公开(公告)日：2023-07-27

申请号：US17768557

申请日：2020-10-16

Applicant: University of Florida Research Foundation, Inc.

Inventor： Jonathan SCHEFFE ,  James Arthur TRAINHAM ,  Bruce COOK

IPC: F24S80/10 ,  F24S10/30 ,  F24S20/20 ,  F24S80/20 ,  F24S10/70 ,  F24S60/00

CPC classification number: F24S80/10 ,  F24S10/30 ,  F24S20/20 ,  F24S80/20 ,  F24S10/70 ,  F24S60/00

Abstract: Provided are solar collection energy storage and energy conversion or chemical conversion systems. Also provided are tubing components, such as for solar receivers, including Mo and having a MoSiB coating on an external surface. The systems can include a solar receiver containing a heat transfer material or chemically reacting material and can operate at temperatures of 700° C. or higher. The solar receiver can include tubing components selected from a Mo tubing component, a MAX phase material tubing component, a MoSiB composite tubing component, or a combination thereof. The Mo component, when present, can include a coating on surfaces of the Mo component that operate above 700° C.

公开(公告)号：US20230227944A1

公开(公告)日：2023-07-20

申请号：US18173158

申请日：2023-02-23

Applicant: University of Florida Research Foundation, Inc. ,  UTBATTELLE, LLC

Inventor： Michele Viola Manuel ,  HUNTER B. HENDERSON ,  ORLANDO RIOS ,  GERARD M. LUDTKA

IPC: C22C1/10 ,  C25D1/00 ,  C25D15/00 ,  H01F1/047 ,  H01F1/44 ,  H05B6/36 ,  B22F1/07 ,  B22F1/054 ,  B22F1/12 ,  B22F1/00 ,  B22F9/06

CPC classification number: C22C1/1084 ,  C25D1/00 ,  C25D15/00 ,  H01F1/047 ,  H01F1/442 ,  H05B6/367 ,  B22F1/07 ,  B22F1/054 ,  B22F1/12 ,  B22F1/00 ,  B22F9/06 ,  B22F2009/042

Abstract: Disclosed herein is a method comprising disposing a container containing a metal and/or ferromagnetic solid and abrasive particles in a static magnetic field; where the container is surrounded by an induction coil; activating the induction coil with an electrical current, to heat up the metallic or ferromagnetic solid to form a fluid; generating sonic energy to produce acoustic cavitation and abrasion between the abrasive particles and the container; and producing nanoparticles that comprise elements from the container, the metal and/or the ferromagnetic solid and the abrasive particles. Disclosed herein too is a composition comprising first metal or a first ceramic; and particles comprising carbides and/or nitrides dispersed therein. Disclosed herein too is a composition comprising nanoparticles comprising chromium carbide, iron carbide, nickel carbide, γ-Fe and magnesium nitride.

公开(公告)号：US11705255B2

公开(公告)日：2023-07-18

申请号：US17210742

申请日：2021-03-24

Applicant: University of Florida Research Foundation, Inc.

Inventor： James F. Klausner ,  Renwei Mei ,  Ayyoub Mehdizadeh Momen ,  Kyle Allen

IPC: H01F1/01 ,  C01B32/50 ,  C04B38/00 ,  H01F1/34 ,  B01J23/745 ,  B01J37/00 ,  B01J37/02 ,  H01F41/00 ,  C04B35/515

CPC classification number: H01F1/01 ,  B01J23/745 ,  B01J37/0009 ,  B01J37/0221 ,  C01B32/50 ,  C04B35/515 ,  C04B38/0038 ,  H01F1/342 ,  H01F41/00 ,  C04B38/0038 ,  C04B35/01 ,  C04B38/0096 ,  C04B38/0038 ,  C04B35/515 ,  C04B38/0096

Abstract: Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid.

公开(公告)号：US20230181746A1

公开(公告)日：2023-06-15

申请号：US17925776

申请日：2021-05-17

Applicant: University of Florida Research Foundation, Inc.

Inventor： Daiqing LIAO ,  Yufeng XIAO ,  Xuan ZHANG ,  Guangrong ZHENG

IPC: A61K47/55 ,  A61P35/00 ,  A61K47/60

CPC classification number: A61K47/55 ,  A61P35/00 ,  A61K47/60

Abstract: In one aspect, the disclosure relates to benzoylhydrazide-derived PROTACs that are highly effective at degrading HDAC3 and that are also capable of targeting, to a lesser extent, other HDAC isoforms, methods of making same, pharmaceutical compositions comprising same, and methods of treating cancers including hematologic cancers, breast cancer, other malignancies, and other serious diseases involving aberrant HDAC activity using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230169889A1

公开(公告)日：2023-06-01

申请号：US17919139

申请日：2021-05-05

Applicant: University of Florida Research Foundation, Inc.

Inventor： Savanna MAHN ,  Ceri BORDE ,  Brian B. HUGHLEY

IPC: G09B23/30 ,  A61L31/12

CPC classification number: G09B23/30 ,  A61L31/12

Abstract: The disclosure relates to a simulated tissue useful as a surgical training aid, the simulated tissue including at least the following: (a) a skin layer, (b) a fat layer, (c) a muscle layer, (d) a first mesh, (e) an interstitial layer, (f) a second mesh, (g) a structural layer incorporating one or more anatomical components, and (h) a base layer. Methods for constructing the simulated tissue are also disclosed. The simulated tissues described herein can be used as a soft tissue surgical task trainer for numerous surgical procedures.

公开(公告)号：US20230158173A1

公开(公告)日：2023-05-25

申请号：US17912690

申请日：2021-03-19

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Christina A. Pacak ,  Peter B. Kang

IPC: A61K48/00 ,  A61P25/00 ,  C12N9/16

CPC classification number: A61K48/0066 ,  A61P25/00 ,  C12N9/16

Abstract: Provided herein are methods of treating a subject with Cockayne Syndrome (CS) or a predisposition thereto. Also provided are methods of treating a subject with one or more mutations in an ERCC5 gene, an ERCC8 gene, an ERCC6 gene, or a combination thereof, methods of delaying the onset of Cockayne Syndrome (CS), or a symptom thereof, in a subject with one or more mutations in an ERCC5 gene, an ERCC8 gene, an ERCC6 gene, or a combination thereof, and methods of slowing, halting or reversing progression of Cockayne Syndrome (CS) in a subject. In exemplary embodiments, the method comprises administering to the subject a replication-incompetent Adeno-associated Vims (riAAV) comprising a nucleotide sequence encoding a Xeroderma Pigmentosum group G (XPG) protein, a Cockayne Syndrome type A (CSA) protein, or a Cockayne Syndrome type B (CSB) protein in an effective amount. Provided herein are related Adeno-associated Virus and cells comprising the same.

公开(公告)号：US20230141896A1

公开(公告)日：2023-05-11

申请号：US17915362

申请日：2021-03-23

Applicant: University of Florida Research Foundation, Inc.

Inventor： Peng Liu ,  Ruogu Fang

IPC: A61B3/00 ,  A61B3/12 ,  G06V10/82 ,  G06V40/18

CPC classification number: A61B3/0025 ,  A61B3/12 ,  G06V10/82 ,  G06V40/197

Abstract: Embodiments of the present disclosure are directed to training a neural network for ocular cup (OC) or ocular disc (OD) detection. One such method comprises initiating training of a first network to learn detection of OC/OD regions within a labeled source sample from a source domain; sharing training weights of the first network with a second network; initiating training of the second network to learn detection of OC/OD regions within an unlabeled sample from a target domain; transferring average training weights of the second network to a third network; initiating training of the third network to learn detection of OC/OD regions within an unlabeled sample from the target domain; computing a mean square error loss between the third network and the second network for a same target sample; and adjusting training weights of the second network based on the mean square error loss computation.