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51.发明授权公开(公告)号：US10307331B2
公开(公告)日：2019-06-04
申请号：US14929253
申请日：2015-10-30
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy Greiner Chambliss
Abstract: A method of treating a mental disorder of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at or near an acupoint corresponding to at least one of a trigeminal nerve and an occipital nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device, the stimulation sessions to at least one of the trigeminal nerve and the occipital nerve by way a central electrode and an annular electrode located on the electroacupuncture device in accordance with the duty cycle.
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公开(公告)号：US10299987B2
公开(公告)日：2019-05-28
申请号：US15918781
申请日：2018-03-12
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
Abstract: An exemplary method includes generating, by an electroacupuncture device implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a location within the patient. A primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms is configured to provide operating power to pulse generation circuitry within the electroacupuncture device.
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53.发明授权公开(公告)号：US10299986B2
公开(公告)日：2019-05-28
申请号：US15421267
申请日：2017-01-31
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
Abstract: An exemplary method treating a cardiovascular disease in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a median nerve of the patient by way of an electrode array located within the patient at an acupoint corresponding to the median nerve.
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54.发明授权公开(公告)号：US09789304B2
公开(公告)日：2017-10-17
申请号：US14805355
申请日：2015-07-21
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61N1/0504 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3605 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10S128/907
Abstract: A method of treating hypertension in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a target tissue location within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location by way of the central electrode and the annular electrode in accordance with the duty cycle.
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公开(公告)号：US09724512B2
公开(公告)日：2017-08-08
申请号：US14609108
申请日：2015-01-29
Applicant: Valencia Technologies Corporation
Inventor： David K. L. Peterson , Stacy Greiner Chambliss
CPC classification number: A61N1/36067 , A61N1/0504 , A61N1/0529 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782
Abstract: An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.
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Patent Agency Ranking
56.发明授权公开(公告)号：US09452104B2
公开(公告)日：2016-09-27
申请号：US14669145
申请日：2015-03-26
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61H39/002 , A61H39/00 , A61H2201/01 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3782 , A61N1/3787 , Y10T29/49002
Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats cardiovascular disease through application of stimulation pulses applied at at least one of acupoints EX-HN1, BL14, HT7, HT5, PC6, ST36, LI11, LU7, and LU2. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位EX-HN1，BL14，HT7，HT5，PC6，ST36，LI11，LU7和LU2中的至少一个上施加的刺激脉冲来治疗心血管疾病。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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公开(公告)号：US20160206507A1
公开(公告)日：2016-07-21
申请号：US15084362
申请日：2016-03-29
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61N1/36067 , A61N1/36096 , A61N1/36107 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , H01L2224/48091 , Y10T29/49002 , H01L2924/00014
Abstract: An electroacupuncture device includes 1) a housing configured to be implanted beneath a skin surface of the patient at an acupoint within the patient, 2) a central electrode centrally located on a first surface of the housing, 3) an annular electrode that surrounds the central electrode on the first surface of the housing, the annular electrode being spaced apart from the central electrode, and 4) pulse generation circuitry located within the housing, wherein the pulse generation circuitry generates stimulation sessions at a duty cycle that is less than 0.05 and applies the stimulation sessions at the acupoint by way of the central electrode and the annular electrode in accordance with the duty cycle.
Abstract translation: 电针装置包括：1）壳体，其被配置成植入在患者的穴位下方的患者皮肤表面下方，2）居中地位于所述外壳的第一表面上的中心电极，3）围绕所述中心的环形电极 电极在壳体的第一表面上，环形电极与中心电极间隔开，以及4）位于壳体内的脉冲发生电路，其中脉冲发生电路以小于0.05的占空比产生刺激会话并应用 根据占空比通过中心电极和环形电极在穴位处的刺激会话。
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公开(公告)号：US09327109B2
公开(公告)日：2016-05-03
申请号：US14446512
申请日：2014-07-30
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61N1/0504 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3605 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10S128/907
Abstract: Disclosed is an implantable, coin-sized, self-contained, leadless electroacupuncture (EA) device having at least two electrode contacts attached to the surface of its housing. The electrodes include a central cathode electrode on a bottom side of the housing, and a circumferential anode electrode that surrounds the cathode electrode. In one embodiment, the anode annular electrode is a ring electrode placed around the perimeter edge of the coin-shaped housing. The EA device is adapted to be implanted through a very small incision, e.g., less than about 2-3 cm in length, directly adjacent to a selected acupuncture site known to moderate or affect a hypertension condition of a patient. Appropriate power management circuitry within the device allows a primary battery having a relatively high internal impedance to be used without causing unacceptable dips in battery voltage when the instantaneous battery current surges. Stimulation pulses are generated during a stimulation session that has a duration of T3 minutes and which is applied every T4 minutes. The duty cycle, or ratio of T3 to T4, is very low, not greater than 0.05. This low duty cycle, along with careful power management, allows the EA device to perform its intended function for several years.
Abstract translation: 公开了一种植入式，硬币大小的独立的无引线电针（EA）装置，其具有附接到其壳体表面的至少两个电极触点。 电极包括在壳体的底侧上的中央阴极电极和围绕阴极电极的周向阳极电极。 在一个实施例中，阳极环形电极是围绕硬币形壳体的周边边缘放置的环形电极。 EA装置适于通过非常小的切口植入，例如长度小于约2-3厘米，直接与已知中度或影响患者高血压状况的所选择的针灸部位相邻。 器件内的合适的电源管理电路允许使用具有相对较高的内部阻抗的一次电池，而不会在瞬间电池电流骤升时导致电池电压的不可接受的下降。 在刺激会话期间产生刺激脉冲，持续时间为T3分钟，每T4分钟应用一次。 T3到T4的占空比或比例很低，不大于0.05。 这个低占空比，以及仔细的电源管理，允许EA设备执行其预期功能几年。
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59.发明申请Implantable Electroacupuncture System and Method for Treating Dyslipidemia and Obesity 有权植入式电针系统及治疗脂血症和肥胖的方法公开(公告)号：US20160008221A1
公开(公告)日：2016-01-14
申请号：US14859098
申请日：2015-09-18
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61F5/0026 , A61H2201/50 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36085 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to at least one of a saphenous nerve and a peroneal nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of the saphenous nerve and the peroneal nerve by way of a central electrode and an annular electrode located on a housing of the electroacupuncture device.
Abstract translation: 一种治疗患者肥胖或血脂异常的示例性方法包括：通过植入患者皮肤表面下方的针刺装置产生对应于患者的隐神经和腓神经中的至少一个的穴位，刺激会话 在小于0.05的占空比下，以及2）通过电针装置根据占空比将刺激会话通过中心电极和环形的至少一个隐神经和腓神经施加 电极位于电针装置的壳体上。
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60.发明申请Implantable Electroacupuncture System and Method for Treating Dyslipidemia and Obesity 有权植入式电针系统及治疗脂血症和肥胖的方法公开(公告)号：US20160008220A1
公开(公告)日：2016-01-14
申请号：US14859088
申请日：2015-09-18
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61F5/0026 , A61H2201/50 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36085 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An exemplary method of treating obesity or dyslipidemia of a patient using a small implantable electroacupuncture device (IEAD) includes 1) implanting the IEAD below the skin surface of the patient at or near a target tissue location selected from the group of target tissue locations comprising acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, LR8 and their underlying nerves, the saphenous nerve and the peroneal nerve, and 2) enabling the IEAD to provide EA stimulation pulses in accordance with a stimulation regimen that provides a stimulation session having a duration of T3 minutes at a rate of once every T4 minutes, where the ratio of T3/T4 is no greater than 0.05, and wherein T3 is at least 10 minutes and no greater than 60 minutes.
Abstract translation: 使用小型可植入电针装置（IEAD）治疗患者的肥胖症或血脂异常的示例性方法包括：1）在选自包括穴位的目标组织位置组的靶组织位置处或附近将患者的皮肤表面植入患者的皮肤表面 ST36，SP4，ST37，ST40，SP6，SP9，K16，LR8及其潜在的神经，隐神经和腓神经，以及2）使IEAD能够根据提供刺激疗程的刺激方案提供EA刺激脉冲 以T3 / T4比不大于0.05的速度每T4分钟一次持续T3分钟，其中T3至少为10分钟且不大于60分钟。
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