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51.发明授权Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权肾损伤和肾衰竭的诊断和预后的方法和组成公开(公告)号：US09360488B2
公开(公告)日：2016-06-07
申请号：US14761591
申请日：2014-01-16
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , G01N33/70 , G01N2333/4703 , G01N2333/4745 , G01N2333/65 , G01N2333/8146 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G06F19/00 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用TIMP2和IGFBP7中的一种或多种的测量尿液浓度与测量的血清肌酐和测量的尿液输出中的一种或多种组合，其结果与受试者的肾脏状态相关，以及 可用于患有或患有肾功能损伤，肾功能减退和/或急性肾功能衰竭的受试者的诊断，预后，风险分层，分期，监测，分类和确定进一步的诊断和治疗方案。
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52.发明申请公开(公告)号：US20160018412A1
公开(公告)日：2016-01-21
申请号：US14708225
申请日：2015-05-09
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/70539 , G01N2333/8107 , G01N2800/347 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays configured to detect a kidney injury marker as diagnostic and prognostic biomarkers in renal injuries.
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53.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20150204892A1
公开(公告)日：2015-07-23
申请号：US14675344
申请日：2015-03-31
申请人： Astute Medical, Inc.
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N33/6893 , G01N2333/775 , G01N2800/347 , G01N2800/50 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Tumor necrosis factor receptor superfamily member 10B, Cadherin-16, Caspase-9, Bcl2 antagonist of cell death, Caspase-1, Cadherin-1, Poly [ADP-ribose] polymerase 1, Cyclin-dependent kinase inhibitor 1, Cadherin-5, Myoglobin, Apolipoprotein A-II, Mucin-16, Carcinoembryonic antigen-related cell adhesion molecule 5, and Cellular tumor antigen p53 as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用检测一种或多种选自肿瘤坏死因子受体超家族成员10B，钙粘着蛋白-16，半胱天冬酶-9，细胞死亡的Bcl2拮抗剂，半胱天冬酶-1，钙粘着蛋白-1的生物标志物的测定法 ，聚[ADP-核糖]聚合酶1，细胞周期蛋白依赖性激酶抑制剂1，钙粘蛋白-5，肌红蛋白，载脂蛋白A-II，粘蛋白16，癌胚抗原相关细胞粘附分子5和细胞肿瘤抗原p53作为诊断和预后 肾损伤中的生物标志物测定。
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54.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20150050674A1
公开(公告)日：2015-02-19
申请号：US14381549
申请日：2013-02-27
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/543
CPC分类号： G01N33/6893 , G01N33/54306 , G01N2333/4706 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect Chitinase-3-like protein 1 as a predictive biomarker in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用配置成检测几丁质酶-3样蛋白1的一种或多种测定作为肾损伤中的预测性生物标志物。
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55.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20150010929A1
公开(公告)日：2015-01-08
申请号：US14381532
申请日：2013-02-27
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , A61M1/1601 , A61M2202/0413 , A61M2205/75 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of SPARC, Follistatin-related protein 1, Tumor necrosis factor receptor superfamily member 21, Growth arrest-specific protein 1, MHC class I polypeptide-related sequence A, Syndecan-1, and WNT1-inducible-signaling pathway protein 1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自以下的肾损伤标志物：SPARC，Follistatin相关蛋白1，肿瘤坏死因子受体超家族成员21，生长停滞特异性蛋白1，MHC I类多肽相关序列A，Syndecan-1和WNT1诱导型信号通路蛋白1作为肾损伤中的诊断和预后生物标志物。
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56.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20140377777A1
公开(公告)日：2014-12-25
申请号：US14363724
申请日：2012-12-07
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/545
CPC分类号： G01N33/545 , G01N33/6893 , G01N2333/8146 , G01N2800/26 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Insulin-like growth factor-binding protein 7, Beta-2-glycoprotein 1, Metalloproteinase inhibitor 2, Alpha-1 Antitrypsin, Leukocyte elastase, Serum Amyloid P Component, C-X-C motif chemokine 6, Immunoglobulin A, Immunoglobulin G subclass I, C-C motif chemokine 24, Neutrophil collagenase, Cathepsin D, C-X-C motif chemokine 13, Involucrin, Interleukin-6 receptor subunit beta, Hepatocyte Growth Factor, CXCL-1, -2, -3, Immunoglobulin G subclass II, Metalloproteinase inhibitor 4, C-C motif chemokine 18, Matrilysin, C-X-C motif chemokine 11, and Antileukoproteinase as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient.
摘要翻译： 本发明涉及用于监测，诊断，预后和确定败血症患者治疗方案的方法和组合物。 特别地，本发明涉及使用检测一种或多种选自胰岛素样生长因子结合蛋白7，β-2-糖蛋白1，金属蛋白酶抑制剂2，α-1抗胰蛋白酶，白细胞弹性蛋白酶， 血清淀粉样蛋白P成分，CXC基序趋化因子6，免疫球蛋白A，免疫球蛋白G亚类I，CC基序趋化因子24，中性粒细胞胶原酶，组织蛋白酶D，CXC基序趋化因子13，Involucrin，白细胞介素-6受体亚基β，肝细胞生长因子，CXCL-1 ，-2，-3，免疫球蛋白G亚类II，金属蛋白酶抑制剂4，CC基序趋化因子18，Matrilysin，CXC基序趋化因子11和抗白细胞蛋白酶作为脓毒症患者肾损伤的诊断和预后生物标志物测定。
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